@article{RN272,
   author = {Kerkhofs, D. and Wong, S. M. and Zhang, E. and Staals, J. and Jansen, J. F. A. and van Oostenbrugge, R. J. and Backes, W. H.},
   title = {Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities},
   journal = {Neurology},
   volume = {96},
   number = {17},
   pages = {e2192-e2200},
   note = {Kerkhofs, Danielle
Wong, Sau May
Zhang, Eleana
Staals, Julie
Jansen, Jacobus F A
van Oostenbrugge, Robert J
Backes, Walter H
eng
Research Support, Non-U.S. Gov't
Neurology. 2021 Apr 27;96(17):e2192-e2200. doi: 10.1212/WNL.0000000000011783. Epub 2021 Mar 24.},
   abstract = {OBJECTIVE: To investigate the 2-year change in parenchymal diffusivity, a quantitative marker of microstructural tissue condition, and the relationship with baseline blood-brain barrier (BBB) permeability, in tissue at risk, i.e., the perilesional zone surrounding white matter hyperintensities (WMH) in patients with cerebral small vessel disease (cSVD). METHODS: Patients with sporadic cSVD (lacunar stroke or mild vascular cognitive impairment) underwent 3T MRI at baseline, including dynamic contrast-enhanced MRI to quantify BBB permeability (i.e., leakage volume and rate) and intravoxel incoherent motion imaging (IVIM), a diffusion technique that provides parenchymal diffusivity D. After 2 years, IVIM was repeated. We assessed the relation between BBB leakage measures at baseline and change in parenchymal diffusivity (D) over 2 years in the perilesional zones (divided in 2-mm contours) surrounding WMH. RESULTS: We analyzed 43 patients (age 68 +/- 12 years, 58% male). In the perilesional zones, D increased 0.10% (confidence interval [CI] 0.07-0.013%) (p < 0.01) per 2 mm closer to the WMH. Furthermore, D over 2 years showed a positive correlation with both baseline BBB leakage volume (r = 0.29 [CI 0.06-0.52], p = 0.013) and leakage rate (r = 0.24 [CI 0.02-0.47], p = 0.034). CONCLUSION: BBB leakage at baseline is related to the 2-year change in parenchymal diffusivity in the perilesional zone of WMH. These results support the hypothesis that BBB impairment might play an early role in subsequent microstructural white matter degeneration as part of the pathophysiology of cSVD.},
   keywords = {Aged
Aged, 80 and over
Blood-Brain Barrier/*pathology/*physiopathology
Cerebral Small Vessel Diseases/*physiopathology
Cognitive Dysfunction/physiopathology
Diffusion Magnetic Resonance Imaging/methods
Female
Gray Matter/physiopathology
Humans
Leukoaraiosis/physiopathology
Male
Middle Aged
White Matter/*physiopathology},
   ISSN = {1526-632X (Electronic)
0028-3878 (Linking)},
   DOI = {10.1212/WNL.0000000000011783},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/33762423},
   year = {2021},
   type = {Journal Article}
}

{"_id":"oBjLyeA5xkL9DNHmW","bibbaseid":"kerkhofs-wong-zhang-staals-jansen-vanoostenbrugge-backes-baselinebloodbrainbarrierleakageandlongitudinalmicrostructuraltissuedamageintheperipheryofwhitematterhyperintensities-2021","author_short":["Kerkhofs, D.","Wong, S. M.","Zhang, E.","Staals, J.","Jansen, J. F. A.","van Oostenbrugge, R. J.","Backes, W. H."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Kerkhofs"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities","journal":"Neurology","volume":"96","number":"17","pages":"e2192-e2200","note":"Kerkhofs, Danielle Wong, Sau May Zhang, Eleana Staals, Julie Jansen, Jacobus F A van Oostenbrugge, Robert J Backes, Walter H eng Research Support, Non-U.S. Gov't Neurology. 2021 Apr 27;96(17):e2192-e2200. doi: 10.1212/WNL.0000000000011783. Epub 2021 Mar 24.","abstract":"OBJECTIVE: To investigate the 2-year change in parenchymal diffusivity, a quantitative marker of microstructural tissue condition, and the relationship with baseline blood-brain barrier (BBB) permeability, in tissue at risk, i.e., the perilesional zone surrounding white matter hyperintensities (WMH) in patients with cerebral small vessel disease (cSVD). METHODS: Patients with sporadic cSVD (lacunar stroke or mild vascular cognitive impairment) underwent 3T MRI at baseline, including dynamic contrast-enhanced MRI to quantify BBB permeability (i.e., leakage volume and rate) and intravoxel incoherent motion imaging (IVIM), a diffusion technique that provides parenchymal diffusivity D. After 2 years, IVIM was repeated. We assessed the relation between BBB leakage measures at baseline and change in parenchymal diffusivity (D) over 2 years in the perilesional zones (divided in 2-mm contours) surrounding WMH. RESULTS: We analyzed 43 patients (age 68 +/- 12 years, 58% male). In the perilesional zones, D increased 0.10% (confidence interval [CI] 0.07-0.013%) (p < 0.01) per 2 mm closer to the WMH. Furthermore, D over 2 years showed a positive correlation with both baseline BBB leakage volume (r = 0.29 [CI 0.06-0.52], p = 0.013) and leakage rate (r = 0.24 [CI 0.02-0.47], p = 0.034). CONCLUSION: BBB leakage at baseline is related to the 2-year change in parenchymal diffusivity in the perilesional zone of WMH. These results support the hypothesis that BBB impairment might play an early role in subsequent microstructural white matter degeneration as part of the pathophysiology of cSVD.","keywords":"Aged Aged, 80 and over Blood-Brain Barrier/*pathology/*physiopathology Cerebral Small Vessel Diseases/*physiopathology Cognitive Dysfunction/physiopathology Diffusion Magnetic Resonance Imaging/methods Female Gray Matter/physiopathology Humans Leukoaraiosis/physiopathology Male Middle Aged White Matter/*physiopathology","issn":"1526-632X (Electronic) 0028-3878 (Linking)","doi":"10.1212/WNL.0000000000011783","url":"https://www.ncbi.nlm.nih.gov/pubmed/33762423","year":"2021","bibtex":"@article{RN272,\n author = {Kerkhofs, D. and Wong, S. M. and Zhang, E. and Staals, J. and Jansen, J. F. A. and van Oostenbrugge, R. J. and Backes, W. H.},\n title = {Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities},\n journal = {Neurology},\n volume = {96},\n number = {17},\n pages = {e2192-e2200},\n note = {Kerkhofs, Danielle\nWong, Sau May\nZhang, Eleana\nStaals, Julie\nJansen, Jacobus F A\nvan Oostenbrugge, Robert J\nBackes, Walter H\neng\nResearch Support, Non-U.S. Gov't\nNeurology. 2021 Apr 27;96(17):e2192-e2200. doi: 10.1212/WNL.0000000000011783. Epub 2021 Mar 24.},\n abstract = {OBJECTIVE: To investigate the 2-year change in parenchymal diffusivity, a quantitative marker of microstructural tissue condition, and the relationship with baseline blood-brain barrier (BBB) permeability, in tissue at risk, i.e., the perilesional zone surrounding white matter hyperintensities (WMH) in patients with cerebral small vessel disease (cSVD). METHODS: Patients with sporadic cSVD (lacunar stroke or mild vascular cognitive impairment) underwent 3T MRI at baseline, including dynamic contrast-enhanced MRI to quantify BBB permeability (i.e., leakage volume and rate) and intravoxel incoherent motion imaging (IVIM), a diffusion technique that provides parenchymal diffusivity D. After 2 years, IVIM was repeated. We assessed the relation between BBB leakage measures at baseline and change in parenchymal diffusivity (D) over 2 years in the perilesional zones (divided in 2-mm contours) surrounding WMH. RESULTS: We analyzed 43 patients (age 68 +/- 12 years, 58% male). In the perilesional zones, D increased 0.10% (confidence interval [CI] 0.07-0.013%) (p < 0.01) per 2 mm closer to the WMH. Furthermore, D over 2 years showed a positive correlation with both baseline BBB leakage volume (r = 0.29 [CI 0.06-0.52], p = 0.013) and leakage rate (r = 0.24 [CI 0.02-0.47], p = 0.034). CONCLUSION: BBB leakage at baseline is related to the 2-year change in parenchymal diffusivity in the perilesional zone of WMH. These results support the hypothesis that BBB impairment might play an early role in subsequent microstructural white matter degeneration as part of the pathophysiology of cSVD.},\n keywords = {Aged\nAged, 80 and over\nBlood-Brain Barrier/*pathology/*physiopathology\nCerebral Small Vessel Diseases/*physiopathology\nCognitive Dysfunction/physiopathology\nDiffusion Magnetic Resonance Imaging/methods\nFemale\nGray Matter/physiopathology\nHumans\nLeukoaraiosis/physiopathology\nMale\nMiddle Aged\nWhite Matter/*physiopathology},\n ISSN = {1526-632X (Electronic)\n0028-3878 (Linking)},\n DOI = {10.1212/WNL.0000000000011783},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/33762423},\n year = {2021},\n type = {Journal Article}\n}\n\n","author_short":["Kerkhofs, D.","Wong, S. M.","Zhang, E.","Staals, J.","Jansen, J. F. A.","van Oostenbrugge, R. J.","Backes, W. H."],"key":"RN272","id":"RN272","bibbaseid":"kerkhofs-wong-zhang-staals-jansen-vanoostenbrugge-backes-baselinebloodbrainbarrierleakageandlongitudinalmicrostructuraltissuedamageintheperipheryofwhitematterhyperintensities-2021","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/33762423"},"keyword":["Aged Aged","80 and over Blood-Brain Barrier/*pathology/*physiopathology Cerebral Small Vessel Diseases/*physiopathology Cognitive Dysfunction/physiopathology Diffusion Magnetic Resonance Imaging/methods Female Gray Matter/physiopathology Humans Leukoaraiosis/physiopathology Male Middle Aged White Matter/*physiopathology"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["aged aged","80 and over blood-brain barrier/*pathology/*physiopathology cerebral small vessel diseases/*physiopathology cognitive dysfunction/physiopathology diffusion magnetic resonance imaging/methods female gray matter/physiopathology humans leukoaraiosis/physiopathology male middle aged white matter/*physiopathology"],"search_terms":["baseline","blood","brain","barrier","leakage","longitudinal","microstructural","tissue","damage","periphery","white","matter","hyperintensities","kerkhofs","wong","zhang","staals","jansen","van oostenbrugge","backes"],"title":"Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities","year":2021}