A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI. Kershaw, J., Tomiyasu, M., Kashikura, K., Hirano, Y., Nonaka, H., Hirano, M., Ikehira, H., Kanno, I., & Obata, T. NMR in Biomedicine, 9999(9999):n/a, 2009.
Paper doi abstract bibtex A new interpretation is proposed for stimulus-induced signal changes in diffusion-weighted functional MRI. T2-weighted spin-echo echo-planar images were acquired at different diffusion-weightings while visual stimulation was presented to human volunteers. The amplitudes of the positive stimulus-correlated response and post-stimulus undershoot (PSU) in the functional time-courses were found to follow different trends as a function of b-value. Data were analysed using a three-compartment signal model, with one compartment being purely vascular and the other two dominated by fast- and slow-diffusing molecules in the brain tissue. The diffusion coefficients of the tissue were assumed to be constant throughout the experiments. It is shown that the stimulus-induced signal changes can be decomposed into independent contributions originating from each of the three compartments. After decomposition, the fast-diffusion phase displays a substantial PSU, while the slow-diffusion phase demonstrates a highly reproducible and stimulus-correlated time-course with minimal undershoot. The decomposed responses are interpreted in terms of the spin-echo blood oxygenation level dependent (SE-BOLD) effect, and it is proposed that the signal produced by fast- and slow-diffusing molecules reflect a sensitivity to susceptibility changes in arteriole/venule- and capillary-sized vessels, respectively. This interpretation suggests that diffusion-weighted SE-BOLD imaging may provide subtle information about the haemodynamic and neuronal responses. Copyright � 2009 John Wiley & Sons, Ltd.
@article{kershaw_multi-compartmental_2009,
title = {A multi-compartmental {SE}-{BOLD} interpretation for stimulus-related signal changes in diffusion-weighted functional {MRI}},
volume = {9999},
url = {http://dx.doi.org/10.1002/nbm.1391},
doi = {10.1002/nbm.1391},
abstract = {A new interpretation is proposed for stimulus-induced signal changes in diffusion-weighted functional MRI. T2-weighted spin-echo echo-planar images were acquired at different diffusion-weightings while visual stimulation was presented to human volunteers. The amplitudes of the positive stimulus-correlated response and post-stimulus undershoot (PSU) in the functional time-courses were found to follow different trends as a function of b-value. Data were analysed using a three-compartment signal model, with one compartment being purely vascular and the other two dominated by fast- and slow-diffusing molecules in the brain tissue. The diffusion coefficients of the tissue were assumed to be constant throughout the experiments. It is shown that the stimulus-induced signal changes can be decomposed into independent contributions originating from each of the three compartments. After decomposition, the fast-diffusion phase displays a substantial PSU, while the slow-diffusion phase demonstrates a highly reproducible and stimulus-correlated time-course with minimal undershoot. The decomposed responses are interpreted in terms of the spin-echo blood oxygenation level dependent (SE-BOLD) effect, and it is proposed that the signal produced by fast- and slow-diffusing molecules reflect a sensitivity to susceptibility changes in arteriole/venule- and capillary-sized vessels, respectively. This interpretation suggests that diffusion-weighted SE-BOLD imaging may provide subtle information about the haemodynamic and neuronal responses. Copyright � 2009 John Wiley \& Sons, Ltd.},
number = {9999},
urldate = {2009-05-06},
journal = {NMR in Biomedicine},
author = {Kershaw, Jeff and Tomiyasu, Moyoko and Kashikura, Kenichi and Hirano, Yoshiyuki and Nonaka, Hiroi and Hirano, Masaya and Ikehira, Hiroo and Kanno, Iwao and Obata, Takayuki},
year = {2009},
keywords = {theory, BOLD, balloonmodel, diffusion},
pages = {n/a},
file = {kershaw2009.pdf:/Users/nickb/Zotero/storage/C7WPPUQQ/kershaw2009.pdf:application/pdf;Wiley InterScience \:\: JOURNALS \:\: NMR in Biomedicine:/Users/nickb/Zotero/storage/UH2G9DGF/abstract.html:text/html}
}
Downloads: 0
{"_id":"FohLExe7Afzr4RJ8Z","bibbaseid":"kershaw-tomiyasu-kashikura-hirano-nonaka-hirano-ikehira-kanno-etal-amulticompartmentalseboldinterpretationforstimulusrelatedsignalchangesindiffusionweightedfunctionalmri-2009","downloads":0,"creationDate":"2017-07-20T09:27:29.876Z","title":"A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI","author_short":["Kershaw, J.","Tomiyasu, M.","Kashikura, K.","Hirano, Y.","Nonaka, H.","Hirano, M.","Ikehira, H.","Kanno, I.","Obata, T."],"year":2009,"bibtype":"article","biburl":"https://users.fmrib.ox.ac.uk/~nickb/ExportedItemsLge.bib","bibdata":{"bibtype":"article","type":"article","title":"A multi-compartmental SE-BOLD interpretation for stimulus-related signal changes in diffusion-weighted functional MRI","volume":"9999","url":"http://dx.doi.org/10.1002/nbm.1391","doi":"10.1002/nbm.1391","abstract":"A new interpretation is proposed for stimulus-induced signal changes in diffusion-weighted functional MRI. T2-weighted spin-echo echo-planar images were acquired at different diffusion-weightings while visual stimulation was presented to human volunteers. The amplitudes of the positive stimulus-correlated response and post-stimulus undershoot (PSU) in the functional time-courses were found to follow different trends as a function of b-value. Data were analysed using a three-compartment signal model, with one compartment being purely vascular and the other two dominated by fast- and slow-diffusing molecules in the brain tissue. The diffusion coefficients of the tissue were assumed to be constant throughout the experiments. It is shown that the stimulus-induced signal changes can be decomposed into independent contributions originating from each of the three compartments. After decomposition, the fast-diffusion phase displays a substantial PSU, while the slow-diffusion phase demonstrates a highly reproducible and stimulus-correlated time-course with minimal undershoot. The decomposed responses are interpreted in terms of the spin-echo blood oxygenation level dependent (SE-BOLD) effect, and it is proposed that the signal produced by fast- and slow-diffusing molecules reflect a sensitivity to susceptibility changes in arteriole/venule- and capillary-sized vessels, respectively. This interpretation suggests that diffusion-weighted SE-BOLD imaging may provide subtle information about the haemodynamic and neuronal responses. Copyright � 2009 John Wiley & Sons, Ltd.","number":"9999","urldate":"2009-05-06","journal":"NMR in Biomedicine","author":[{"propositions":[],"lastnames":["Kershaw"],"firstnames":["Jeff"],"suffixes":[]},{"propositions":[],"lastnames":["Tomiyasu"],"firstnames":["Moyoko"],"suffixes":[]},{"propositions":[],"lastnames":["Kashikura"],"firstnames":["Kenichi"],"suffixes":[]},{"propositions":[],"lastnames":["Hirano"],"firstnames":["Yoshiyuki"],"suffixes":[]},{"propositions":[],"lastnames":["Nonaka"],"firstnames":["Hiroi"],"suffixes":[]},{"propositions":[],"lastnames":["Hirano"],"firstnames":["Masaya"],"suffixes":[]},{"propositions":[],"lastnames":["Ikehira"],"firstnames":["Hiroo"],"suffixes":[]},{"propositions":[],"lastnames":["Kanno"],"firstnames":["Iwao"],"suffixes":[]},{"propositions":[],"lastnames":["Obata"],"firstnames":["Takayuki"],"suffixes":[]}],"year":"2009","keywords":"theory, BOLD, balloonmodel, diffusion","pages":"n/a","file":"kershaw2009.pdf:/Users/nickb/Zotero/storage/C7WPPUQQ/kershaw2009.pdf:application/pdf;Wiley InterScience \\:\\: JOURNALS \\:\\: NMR in Biomedicine:/Users/nickb/Zotero/storage/UH2G9DGF/abstract.html:text/html","bibtex":"@article{kershaw_multi-compartmental_2009,\n\ttitle = {A multi-compartmental {SE}-{BOLD} interpretation for stimulus-related signal changes in diffusion-weighted functional {MRI}},\n\tvolume = {9999},\n\turl = {http://dx.doi.org/10.1002/nbm.1391},\n\tdoi = {10.1002/nbm.1391},\n\tabstract = {A new interpretation is proposed for stimulus-induced signal changes in diffusion-weighted functional MRI. T2-weighted spin-echo echo-planar images were acquired at different diffusion-weightings while visual stimulation was presented to human volunteers. The amplitudes of the positive stimulus-correlated response and post-stimulus undershoot (PSU) in the functional time-courses were found to follow different trends as a function of b-value. Data were analysed using a three-compartment signal model, with one compartment being purely vascular and the other two dominated by fast- and slow-diffusing molecules in the brain tissue. The diffusion coefficients of the tissue were assumed to be constant throughout the experiments. It is shown that the stimulus-induced signal changes can be decomposed into independent contributions originating from each of the three compartments. After decomposition, the fast-diffusion phase displays a substantial PSU, while the slow-diffusion phase demonstrates a highly reproducible and stimulus-correlated time-course with minimal undershoot. The decomposed responses are interpreted in terms of the spin-echo blood oxygenation level dependent (SE-BOLD) effect, and it is proposed that the signal produced by fast- and slow-diffusing molecules reflect a sensitivity to susceptibility changes in arteriole/venule- and capillary-sized vessels, respectively. This interpretation suggests that diffusion-weighted SE-BOLD imaging may provide subtle information about the haemodynamic and neuronal responses. Copyright � 2009 John Wiley \\& Sons, Ltd.},\n\tnumber = {9999},\n\turldate = {2009-05-06},\n\tjournal = {NMR in Biomedicine},\n\tauthor = {Kershaw, Jeff and Tomiyasu, Moyoko and Kashikura, Kenichi and Hirano, Yoshiyuki and Nonaka, Hiroi and Hirano, Masaya and Ikehira, Hiroo and Kanno, Iwao and Obata, Takayuki},\n\tyear = {2009},\n\tkeywords = {theory, BOLD, balloonmodel, diffusion},\n\tpages = {n/a},\n\tfile = {kershaw2009.pdf:/Users/nickb/Zotero/storage/C7WPPUQQ/kershaw2009.pdf:application/pdf;Wiley InterScience \\:\\: JOURNALS \\:\\: NMR in Biomedicine:/Users/nickb/Zotero/storage/UH2G9DGF/abstract.html:text/html}\n}\n\n","author_short":["Kershaw, J.","Tomiyasu, M.","Kashikura, K.","Hirano, Y.","Nonaka, H.","Hirano, M.","Ikehira, H.","Kanno, I.","Obata, T."],"key":"kershaw_multi-compartmental_2009","id":"kershaw_multi-compartmental_2009","bibbaseid":"kershaw-tomiyasu-kashikura-hirano-nonaka-hirano-ikehira-kanno-etal-amulticompartmentalseboldinterpretationforstimulusrelatedsignalchangesindiffusionweightedfunctionalmri-2009","role":"author","urls":{"Paper":"http://dx.doi.org/10.1002/nbm.1391"},"keyword":["theory","BOLD","balloonmodel","diffusion"],"downloads":0,"html":""},"search_terms":["multi","compartmental","bold","interpretation","stimulus","related","signal","changes","diffusion","weighted","functional","mri","kershaw","tomiyasu","kashikura","hirano","nonaka","hirano","ikehira","kanno","obata"],"keywords":["theory","bold","balloonmodel","diffusion"],"authorIDs":[],"dataSources":["ZnSCiZ543imjXQzRu"]}