Effects of inorganic mercury on reproductive performance of mice. Khan, A., T.; Atkinson, A.; Graham, T., C.; Thompson, S., J.; Ali, S.; and Shireen, K., F. Food and Chemical Toxicology, 42(4):571-577, 4, 2004.
Effects of inorganic mercury on reproductive performance of mice [link]Website  abstract   bibtex   
Effects of mercuric chloride (MC) on the reproductive performance of mice were evaluated. Both male and female mice were divided into four groups that were subsequently exposed to 0.00, 0.25, 0.50, and 1.00 mg/kg/day of MC, respectively. At the end of pre-mating dosing, males were paired with females receiving the same dose. Dosing continued for males throughout mating, while dosing in females continued throughout mating, gestation, and lactation. The males were necropsied at the conclusion of mating and the females were necropsied at the conclusion of lactation. Fertility indices, parturition, gestation, live birth litter size, survival indices, and implantation efficiency were recorded. Subsequently, these data were statistically analyzed. Fertility and survival indices were significantly reduced in the treated groups. Exposure of mice to MC did not affect their litter size. No evidence of mercury induced target organ toxicity was seen in either the clinical pathology parameters or histomorphologic evaluations. However, in MC treated females, ovary weights were significantly different from the control. There were no histomorphologic or clinical pathology effects induced by MC. These results suggested that oral exposure to 0.25-1.00 mg/kg/day of MC produced adverse effects on the reproductive performance of mice in the absence of overt mercury toxicity.
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 title = {Effects of inorganic mercury on reproductive performance of mice},
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 year = {2004},
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 keywords = {Administration,Animals,Dose-Response Relationship,Drug,Environmental Pollutants,Environmental Pollutants: administration & dosage,Environmental Pollutants: toxicity,Female,Fertility,Fertility: drug effects,Inbred C57BL,Longevity,Longevity: drug effects,Male,Maternal Exposure,Mercuric Chloride,Mercuric Chloride: administration & dosage,Mercuric Chloride: toxicity,Mice,Oral,Organ Size,Organ Size: drug effects,Ovary,Ovary: drug effects,Ovary: pathology,Paternal Exposure,Pregnancy,Specific Pathogen-Free Organisms},
 pages = {571-577},
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 abstract = {Effects of mercuric chloride (MC) on the reproductive performance of mice were evaluated. Both male and female mice were divided into four groups that were subsequently exposed to 0.00, 0.25, 0.50, and 1.00 mg/kg/day of MC, respectively. At the end of pre-mating dosing, males were paired with females receiving the same dose. Dosing continued for males throughout mating, while dosing in females continued throughout mating, gestation, and lactation. The males were necropsied at the conclusion of mating and the females were necropsied at the conclusion of lactation. Fertility indices, parturition, gestation, live birth litter size, survival indices, and implantation efficiency were recorded. Subsequently, these data were statistically analyzed. Fertility and survival indices were significantly reduced in the treated groups. Exposure of mice to MC did not affect their litter size. No evidence of mercury induced target organ toxicity was seen in either the clinical pathology parameters or histomorphologic evaluations. However, in MC treated females, ovary weights were significantly different from the control. There were no histomorphologic or clinical pathology effects induced by MC. These results suggested that oral exposure to 0.25-1.00 mg/kg/day of MC produced adverse effects on the reproductive performance of mice in the absence of overt mercury toxicity.},
 bibtype = {article},
 author = {Khan, Abu T and Atkinson, Alfonza and Graham, Thomas C and Thompson, Sherylee J and Ali, Salwa and Shireen, Kaniz F},
 journal = {Food and Chemical Toxicology},
 number = {4}
}
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