Rheumatic and Musculoskeletal Diseases and Risk of Dementia: A Nested Case-Control Study. Kiadaliri, A., Dell'Isola, A., Turkiewicz, A., & Englund, M. ACR open rheumatology, 6(8):504–510, August, 2024. doi abstract bibtex OBJECTIVE: To investigate the associations between rheumatic and musculoskeletal diseases (RMDs) and incident dementia using population register-based data. METHODS: This nested case-control study was conducted based on a cohort of residents in the Skåne region, Sweden, aged 50 years and older in 2009 without doctor-diagnosed dementia during 1998 to 2009 (n = 402,825). Individuals with a new main diagnosis of dementia during 2010 to 2019 were identified as incident patients with dementia (n = 22,131). Controls without diagnosed dementia were randomly matched 1:1 by sex, age, and Elixhauser comorbidity index using incidence density sampling. Separate conditional logistic regression analyses adjusted for confounders were fitted for the following RMDs, diagnosed at least 2 years before dementia diagnosis as exposure: gout, osteoarthritis, rheumatoid arthritis, spondyloarthropathies (SpA), and systemic connective tissue disorders. Subgroup analyses by dementia subtype, sex, age, comorbidity, and RMDs/dementia identification were conducted. RESULTS: Although gout (adjusted rate ratio 0.88; 95% confidence interval 0.79-0.97), osteoarthritis (0.92; 0.88-0.96), and systemic connective tissue disorders (0.91; 0.83-0.99) were associated with decreased risk of dementia, the associations for rheumatoid arthritis (1.05; 0.92-1.19) and SpA (1.17; 0.94-1.45) were inconclusive. The associations between RMDs and incident dementia were similar across sex, age, and comorbidity subgroups with a few exceptions (eg, an adjusted rate ratio of 0.99 [95% confidence interval 0.71-1.39] in males vs 1.31 [0.99-1.74] in female patients for SpA). CONCLUSION: Persons with diagnosed RMDs seem to have comparable or slightly lower risks of developing dementia compared with those without known RMD.
@article{kiadaliri_rheumatic_2024,
title = {Rheumatic and {Musculoskeletal} {Diseases} and {Risk} of {Dementia}: {A} {Nested} {Case}-{Control} {Study}},
volume = {6},
issn = {2578-5745},
shorttitle = {Rheumatic and {Musculoskeletal} {Diseases} and {Risk} of {Dementia}},
doi = {10.1002/acr2.11705},
abstract = {OBJECTIVE: To investigate the associations between rheumatic and musculoskeletal diseases (RMDs) and incident dementia using population register-based data.
METHODS: This nested case-control study was conducted based on a cohort of residents in the Skåne region, Sweden, aged 50 years and older in 2009 without doctor-diagnosed dementia during 1998 to 2009 (n = 402,825). Individuals with a new main diagnosis of dementia during 2010 to 2019 were identified as incident patients with dementia (n = 22,131). Controls without diagnosed dementia were randomly matched 1:1 by sex, age, and Elixhauser comorbidity index using incidence density sampling. Separate conditional logistic regression analyses adjusted for confounders were fitted for the following RMDs, diagnosed at least 2 years before dementia diagnosis as exposure: gout, osteoarthritis, rheumatoid arthritis, spondyloarthropathies (SpA), and systemic connective tissue disorders. Subgroup analyses by dementia subtype, sex, age, comorbidity, and RMDs/dementia identification were conducted.
RESULTS: Although gout (adjusted rate ratio 0.88; 95\% confidence interval 0.79-0.97), osteoarthritis (0.92; 0.88-0.96), and systemic connective tissue disorders (0.91; 0.83-0.99) were associated with decreased risk of dementia, the associations for rheumatoid arthritis (1.05; 0.92-1.19) and SpA (1.17; 0.94-1.45) were inconclusive. The associations between RMDs and incident dementia were similar across sex, age, and comorbidity subgroups with a few exceptions (eg, an adjusted rate ratio of 0.99 [95\% confidence interval 0.71-1.39] in males vs 1.31 [0.99-1.74] in female patients for SpA).
CONCLUSION: Persons with diagnosed RMDs seem to have comparable or slightly lower risks of developing dementia compared with those without known RMD.},
language = {eng},
number = {8},
journal = {ACR open rheumatology},
author = {Kiadaliri, Ali and Dell'Isola, Andrea and Turkiewicz, Aleksandra and Englund, Martin},
month = aug,
year = {2024},
pages = {504--510},
}
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Individuals with a new main diagnosis of dementia during 2010 to 2019 were identified as incident patients with dementia (n = 22,131). Controls without diagnosed dementia were randomly matched 1:1 by sex, age, and Elixhauser comorbidity index using incidence density sampling. Separate conditional logistic regression analyses adjusted for confounders were fitted for the following RMDs, diagnosed at least 2 years before dementia diagnosis as exposure: gout, osteoarthritis, rheumatoid arthritis, spondyloarthropathies (SpA), and systemic connective tissue disorders. Subgroup analyses by dementia subtype, sex, age, comorbidity, and RMDs/dementia identification were conducted. RESULTS: Although gout (adjusted rate ratio 0.88; 95% confidence interval 0.79-0.97), osteoarthritis (0.92; 0.88-0.96), and systemic connective tissue disorders (0.91; 0.83-0.99) were associated with decreased risk of dementia, the associations for rheumatoid arthritis (1.05; 0.92-1.19) and SpA (1.17; 0.94-1.45) were inconclusive. The associations between RMDs and incident dementia were similar across sex, age, and comorbidity subgroups with a few exceptions (eg, an adjusted rate ratio of 0.99 [95% confidence interval 0.71-1.39] in males vs 1.31 [0.99-1.74] in female patients for SpA). CONCLUSION: Persons with diagnosed RMDs seem to have comparable or slightly lower risks of developing dementia compared with those without known RMD.","language":"eng","number":"8","journal":"ACR open rheumatology","author":[{"propositions":[],"lastnames":["Kiadaliri"],"firstnames":["Ali"],"suffixes":[]},{"propositions":[],"lastnames":["Dell'Isola"],"firstnames":["Andrea"],"suffixes":[]},{"propositions":[],"lastnames":["Turkiewicz"],"firstnames":["Aleksandra"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]}],"month":"August","year":"2024","pages":"504–510","bibtex":"@article{kiadaliri_rheumatic_2024,\n\ttitle = {Rheumatic and {Musculoskeletal} {Diseases} and {Risk} of {Dementia}: {A} {Nested} {Case}-{Control} {Study}},\n\tvolume = {6},\n\tissn = {2578-5745},\n\tshorttitle = {Rheumatic and {Musculoskeletal} {Diseases} and {Risk} of {Dementia}},\n\tdoi = {10.1002/acr2.11705},\n\tabstract = {OBJECTIVE: To investigate the associations between rheumatic and musculoskeletal diseases (RMDs) and incident dementia using population register-based data.\nMETHODS: This nested case-control study was conducted based on a cohort of residents in the Skåne region, Sweden, aged 50 years and older in 2009 without doctor-diagnosed dementia during 1998 to 2009 (n = 402,825). Individuals with a new main diagnosis of dementia during 2010 to 2019 were identified as incident patients with dementia (n = 22,131). Controls without diagnosed dementia were randomly matched 1:1 by sex, age, and Elixhauser comorbidity index using incidence density sampling. Separate conditional logistic regression analyses adjusted for confounders were fitted for the following RMDs, diagnosed at least 2 years before dementia diagnosis as exposure: gout, osteoarthritis, rheumatoid arthritis, spondyloarthropathies (SpA), and systemic connective tissue disorders. Subgroup analyses by dementia subtype, sex, age, comorbidity, and RMDs/dementia identification were conducted.\nRESULTS: Although gout (adjusted rate ratio 0.88; 95\\% confidence interval 0.79-0.97), osteoarthritis (0.92; 0.88-0.96), and systemic connective tissue disorders (0.91; 0.83-0.99) were associated with decreased risk of dementia, the associations for rheumatoid arthritis (1.05; 0.92-1.19) and SpA (1.17; 0.94-1.45) were inconclusive. The associations between RMDs and incident dementia were similar across sex, age, and comorbidity subgroups with a few exceptions (eg, an adjusted rate ratio of 0.99 [95\\% confidence interval 0.71-1.39] in males vs 1.31 [0.99-1.74] in female patients for SpA).\nCONCLUSION: Persons with diagnosed RMDs seem to have comparable or slightly lower risks of developing dementia compared with those without known RMD.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {ACR open rheumatology},\n\tauthor = {Kiadaliri, Ali and Dell'Isola, Andrea and Turkiewicz, Aleksandra and Englund, Martin},\n\tmonth = aug,\n\tyear = {2024},\n\tpages = {504--510},\n}\n\n","author_short":["Kiadaliri, A.","Dell'Isola, A.","Turkiewicz, A.","Englund, M."],"key":"kiadaliri_rheumatic_2024","id":"kiadaliri_rheumatic_2024","bibbaseid":"kiadaliri-dellisola-turkiewicz-englund-rheumaticandmusculoskeletaldiseasesandriskofdementiaanestedcasecontrolstudy-2024","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["LPTeGao77ndnG4Tks"],"keywords":[],"search_terms":["rheumatic","musculoskeletal","diseases","risk","dementia","nested","case","control","study","kiadaliri","dell'isola","turkiewicz","englund"],"title":"Rheumatic and Musculoskeletal Diseases and Risk of Dementia: A Nested Case-Control Study","year":2024}