Understanding human DNA sequence variation. Kidd, K., K.; Pakstis, A., J.; Speed, W., C.; and Kidd, J., R. J Hered, 95(5):406-420, 2004.
Understanding human DNA sequence variation [pdf]Paper  Understanding human DNA sequence variation [link]Website  abstract   bibtex   
Over the past century researchers have identified normal genetic variation and studied that variation in diverse human populations to determine the amounts and distributions of that variation. That information is being used to develop an understanding of the demographic histories of the different populations and the species as a whole, among other studies. With the advent of DNA-based markers in the last quarter century, these studies have accelerated. One of the challenges for the next century is to understand that variation. One component of that understanding will be population genetics. We present here examples of many of the ways these new data can be analyzed from a population perspective using results from our laboratory on multiple individual DNA-based polymorphisms, many clustered in haplotypes, studied in multiple populations representing all major geographic regions of the world. These data support an "out of Africa" hypothesis for human dispersal around the world and begin to refine the understanding of population structures and genetic relationships. We are also developing baseline information against which we can compare findings at different loci to aid in the identification of loci subject, now and in the past, to selection (directional or balancing). We do not yet have a comprehensive understanding of the extensive variation in the human genome, but some of that understanding is coming from population genetics.
@article{
 title = {Understanding human DNA sequence variation},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {*Base Sequence,*Genetic Variation,*Genetics, Population,*Models, Biological,Demography,Gene Frequency,Genetics/history/*trends,Geography,Haplotypes/genetics,Heterozygote Detection,History, 20th Century,History, 21st Century,Humans,Polymorphism, Genetic},
 pages = {406-420},
 volume = {95},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15388768},
 edition = {2004/09/25},
 id = {7dff6a8d-4751-36dd-847d-0b01133760d1},
 created = {2017-06-19T13:42:58.571Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:42:58.728Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Kidd, K K<m:linebreak/>Pakstis, A J<m:linebreak/>Speed, W C<m:linebreak/>Kidd, J R<m:linebreak/>AA09379/AA/NIAAA NIH HHS/United States<m:linebreak/>GM57672/GM/NIGMS NIH HHS/United States<m:linebreak/>MH62495/MH/NIMH NIH HHS/United States<m:linebreak/>Historical Article<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>Research Support, U.S. Gov't, Non-P.H.S.<m:linebreak/>Research Support, U.S. Gov't, P.H.S.<m:linebreak/>Review<m:linebreak/>United States<m:linebreak/>The Journal of heredity<m:linebreak/>95/5/406<m:linebreak/>J Hered. 2004 Sep-Oct;95(5):406-20.</m:note>},
 abstract = {Over the past century researchers have identified normal genetic variation and studied that variation in diverse human populations to determine the amounts and distributions of that variation. That information is being used to develop an understanding of the demographic histories of the different populations and the species as a whole, among other studies. With the advent of DNA-based markers in the last quarter century, these studies have accelerated. One of the challenges for the next century is to understand that variation. One component of that understanding will be population genetics. We present here examples of many of the ways these new data can be analyzed from a population perspective using results from our laboratory on multiple individual DNA-based polymorphisms, many clustered in haplotypes, studied in multiple populations representing all major geographic regions of the world. These data support an "out of Africa" hypothesis for human dispersal around the world and begin to refine the understanding of population structures and genetic relationships. We are also developing baseline information against which we can compare findings at different loci to aid in the identification of loci subject, now and in the past, to selection (directional or balancing). We do not yet have a comprehensive understanding of the extensive variation in the human genome, but some of that understanding is coming from population genetics.},
 bibtype = {article},
 author = {Kidd, K K and Pakstis, A J and Speed, W C and Kidd, J R},
 journal = {J Hered},
 number = {5}
}
Downloads: 0