Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation. Kim, K., Bolotin, E., Theusch, E., Huang, H., Medina, M. W, & Krauss, R. M Genome Biology, 15(9):460, September, 2014.
Paper doi abstract bibtex Statins are widely prescribed for lowering LDL-cholesterol (LDLC) levels and risk of cardiovascular disease. There is, however, substantial inter-individual variation in the magnitude of statin-induced LDLC reduction. To date, analysis of individual DNA sequence variants has explained only a small proportion of this variability. The present study was aimed at assessing whether transcriptomic analyses could be used to identify additional genetic contributions to inter-individual differences in statin efficacy.
@article{kim_prediction_2014,
title = {Prediction of {LDL} cholesterol response to statin using transcriptomic and genetic variation},
volume = {15},
url = {http://genomebiology.com/2014/15/9/460},
doi = {10.1186/s13059-014-0460-9},
abstract = {Statins are widely prescribed for lowering LDL-cholesterol (LDLC) levels and risk of cardiovascular disease. There is, however, substantial inter-individual variation in the magnitude of statin-induced LDLC reduction. To date, analysis of individual DNA sequence variants has explained only a small proportion of this variability. The present study was aimed at assessing whether transcriptomic analyses could be used to identify additional genetic contributions to inter-individual differences in statin efficacy.},
language = {English},
number = {9},
journal = {Genome Biology},
author = {Kim, Kyungpil and Bolotin, Eugene and Theusch, Elizabeth and Huang, Haiyan and Medina, Marisa W and Krauss, Ronald M},
month = sep,
year = {2014},
pages = {460},
}
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