Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Kim, K. H., Bose, D. D, Ghogha, A., Riehl, J., Zhang, R., Barnhart, C. D, Lein, P. J, & Pessah, I. N Environmental health perspectives, 119(4):519–26, April, 2011.
Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. [link]Paper  doi  abstract   bibtex   
Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+))signaling; however, specific mechanisms have yet to be defined.
@article{kim_para-_2011,
	title = {Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity.},
	volume = {119},
	issn = {1552-9924},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3080935&tool=pmcentrez&rendertype=abstract},
	doi = {10.1289/ehp.1002728},
	abstract = {Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+))signaling; however, specific mechanisms have yet to be defined.},
	number = {4},
	journal = {Environmental health perspectives},
	author = {Kim, Kyung Ho and Bose, Diptiman D and Ghogha, Atefeh and Riehl, Joyce and Zhang, Rui and Barnhart, Christopher D and Lein, Pamela J and Pessah, Isaac N},
	month = apr,
	year = {2011},
	pmid = {21106467},
	keywords = {Animals, Calcium, Calcium Signaling, Calcium Signaling: drug effects, Calcium: metabolism, Environmental Pollutants, Environmental Pollutants: chemistry, Environmental Pollutants: metabolism, Environmental Pollutants: toxicity, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: chemistry, Halogenated Diphenyl Ethers: metabolism, Halogenated Diphenyl Ethers: toxicity, Humans, Nervous System, Nervous System: drug effects, Nervous System: metabolism, Rats, Ryanodine Receptor Calcium Release Channel, Ryanodine Receptor Calcium Release Channel: metabo, Sprague-Dawley, Structure-Activity Relationship, cell line},
	pages = {519--26},
}

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