Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. Kim, S. W.; Park, J.; Spring, C. M.; Sater, A. K.; Ji, H.; Otchere, A. A.; Daniel, J. M.; and McCrea, P. D. Nature Cell Biology, 6(12):1212–1220, December, 2004.
Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin [link]Paper  doi  abstract   bibtex   2 downloads  
Gastrulation movements are critical for establishing the three principal germ layers and the basic architecture of vertebrate embryos. Although the individual molecules and pathways involved are not clearly understood, non-canonical Wnt signals are known to participate in developmental processes, including planar cell polarity and directed cell rearrangements. Here we demonstrate that the dual-specificity transcriptional repressor Kaiso, first identified in association with p120-catenin, is required for Xenopus gastrulation movements. In addition, depletion of xKaiso results in increased expression of the non-canonical xWnt11, which contributes to the xKaiso knockdown phenotype as it is significantly rescued by dominant-negative Wnt11. We further demonstrate that xWnt11 is a direct gene target of xKaiso and that p120-catenin association relieves xKaiso repression in vivo. Our results indicate that p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis.
@article{kim_non-canonical_2004,
	title = {Non-canonical {Wnt} signals are modulated by the {Kaiso} transcriptional repressor and p120-catenin},
	volume = {6},
	issn = {1465-7392},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15543138 http://www.nature.com/articles/ncb1191},
	doi = {10.1038/ncb1191},
	abstract = {Gastrulation movements are critical for establishing the three principal germ layers and the basic architecture of vertebrate embryos. Although the individual molecules and pathways involved are not clearly understood, non-canonical Wnt signals are known to participate in developmental processes, including planar cell polarity and directed cell rearrangements. Here we demonstrate that the dual-specificity transcriptional repressor Kaiso, first identified in association with p120-catenin, is required for Xenopus gastrulation movements. In addition, depletion of xKaiso results in increased expression of the non-canonical xWnt11, which contributes to the xKaiso knockdown phenotype as it is significantly rescued by dominant-negative Wnt11. We further demonstrate that xWnt11 is a direct gene target of xKaiso and that p120-catenin association relieves xKaiso repression in vivo. Our results indicate that p120-catenin and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis.},
	number = {12},
	journal = {Nature Cell Biology},
	author = {Kim, Si Wan and Park, Jae-Il and Spring, Christopher M. and Sater, Amy K. and Ji, Hong and Otchere, Abena A. and Daniel, Juliet M. and McCrea, Pierre D.},
	month = dec,
	year = {2004},
	pmid = {15543138},
	pages = {1212--1220}
}
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