Wnt Signaling in Kidney Organogenesis. Kimmo, H. & Seppo, V. In Wnt Signaling in Development and Disease, pages 303–313. John Wiley & Sons, Ltd, 2014. ![Wnt Signaling in Kidney Organogenesis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex This chapter sums up the essential literature concerning Wnt signaling in kidney organogenesis. Wnt signaling has an essential role in multiple aspects of kidney development, from induction of the cap mesenchyme to maturation of the nephron. Primary nephrogenic induction of Wnt9b targets the cap mesenchyme, which in response commences expression of Wnt4, fibroblast growth factor 8 (Fgf8), paired box gene 8 (Pax8), and LIM homeobox protein 1 (Lhx1). Glial cell line-derived neurotrophic factor and ret proto-oncogene (GDNF/Ret) signaling acts as a critical signaling pathway to promote ureteric bud outgrowth from the Wolffian duct and subsequent branching morphogenesis into the collecting duct system. Filtration of plasma takes place in the kidney cortex, whereas concentration of urine and thus osmoregulation of plasma occurs in the medullary region where the Henle's loops and collecting ducts reside.
@incollection{kimmo_wnt_2014-1,
title = {Wnt {Signaling} in {Kidney} {Organogenesis}},
copyright = {Copyright © 2014 John Wiley \& Sons, Inc.},
isbn = {978-1-118-44412-2},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118444122.ch23},
abstract = {This chapter sums up the essential literature concerning Wnt signaling in kidney organogenesis. Wnt signaling has an essential role in multiple aspects of kidney development, from induction of the cap mesenchyme to maturation of the nephron. Primary nephrogenic induction of Wnt9b targets the cap mesenchyme, which in response commences expression of Wnt4, fibroblast growth factor 8 (Fgf8), paired box gene 8 (Pax8), and LIM homeobox protein 1 (Lhx1). Glial cell line-derived neurotrophic factor and ret proto-oncogene (GDNF/Ret) signaling acts as a critical signaling pathway to promote ureteric bud outgrowth from the Wolffian duct and subsequent branching morphogenesis into the collecting duct system. Filtration of plasma takes place in the kidney cortex, whereas concentration of urine and thus osmoregulation of plasma occurs in the medullary region where the Henle's loops and collecting ducts reside.},
language = {en},
urldate = {2019-08-29},
booktitle = {Wnt {Signaling} in {Development} and {Disease}},
publisher = {John Wiley \& Sons, Ltd},
author = {Kimmo, Halt and Seppo, Vainio},
year = {2014},
doi = {10.1002/9781118444122.ch23},
keywords = {collecting duct system, kidney organogenesis, nephron induction, nephron maturation, renal medulla, Wnt signaling},
pages = {303--313},
file = {Snapshot:/Users/cristina/Zotero/storage/Y59EYTS6/9781118444122.html:text/html},
}
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