@article{kimura__2009,
	title = {) with an unstable -globin variant ({Hb} {Icaria}): {First} report on the occurrence in {Brazil}},
	abstract = {Hb H Disease is caused by the loss or inactivation of three of the four functional -globin genes. Patients present chronic hemolytic anemia and splenomegaly. In some cases, occasional blood transfusions are required. Deletions are the main cause of this type of thalassemia (-thalassemia). We describe here an unusual case of Hb H disease caused by the combination of a common 0 deletion (-() 20.5 ) with a rare point mutation (c.427T {\textgreater} A), thus resulting in an elongated and unstable -globin variant, Hb Icaria, (X142K), with 31 additional amino-acid residues. Very high levels of Hb H and Hb Bart's were detected in the patient's red blood cells (14.7 and 19.0\%, respectively). This is the first description of this infrequent association in the Brazilian population.},
	author = {Kimura, Elza M. and Oliveira, Denise M. and Fertrin, Kleber Yotsumoto and {Kleber Yotsumoto Fertrin} and Pinheiro, Valéria R. and Costa, Fernando Ferreira and Costa, Fernando F. and de Fátima Sonati, Maria and de Fatima Sonati, Maria and Boldrini, Domingos A.},
	month = jan,
	year = {2009},
	note = {MAG ID: 2598161577},
}

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