@article{kingston_specific_2021,
	title = {Specific {Endothelial} {Cells} {Govern} {Nanoparticle} {Entry} into {Solid} {Tumors}},
	volume = {15},
	issn = {1936-0851},
	url = {https://doi.org/10.1021/acsnano.1c04510},
	doi = {10.1021/acsnano.1c04510},
	abstract = {The successful delivery of nanoparticles to solid tumors depends on their ability to pass through blood vessels and into the tumor microenvironment. Here, we discovered a subset of tumor endothelial cells that facilitate nanoparticle transport into solid tumors. We named these cells nanoparticle transport endothelial cells (N-TECs). We show that only 21\% of tumor endothelial cells located on a small number of vessels are involved in transporting nanoparticles into the tumor microenvironment. N-TECs have an increased expression of genes related to nanoparticle transport and vessel permeability compared to other tumor endothelial cells. The N-TECs act as gatekeepers that determine the entry point, distribution, cell accessibility, and number of nanoparticles that enter the tumor microenvironment.},
	number = {9},
	urldate = {2021-11-06},
	journal = {ACS Nano},
	author = {Kingston, Benjamin R. and Lin, Zachary P. and Ouyang, Ben and MacMillan, Presley and Ngai, Jessica and Syed, Abdullah Muhammad and Sindhwani, Shrey and Chan, Warren C. W.},
	month = sep,
	year = {2021},
	note = {Publisher: American Chemical Society},
	pages = {14080--14094},
	file = {Full Text PDF:files/1767/Kingston et al. - 2021 - Specific Endothelial Cells Govern Nanoparticle Ent.pdf:application/pdf;ACS Full Text Snapshot:files/1768/acsnano.html:text/html},
	url_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2022/01/KINGST1.pdf}
}

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We show that only 21% of tumor endothelial cells located on a small number of vessels are involved in transporting nanoparticles into the tumor microenvironment. N-TECs have an increased expression of genes related to nanoparticle transport and vessel permeability compared to other tumor endothelial cells. The N-TECs act as gatekeepers that determine the entry point, distribution, cell accessibility, and number of nanoparticles that enter the tumor microenvironment.","number":"9","urldate":"2021-11-06","journal":"ACS Nano","author":[{"propositions":[],"lastnames":["Kingston"],"firstnames":["Benjamin","R."],"suffixes":[]},{"propositions":[],"lastnames":["Lin"],"firstnames":["Zachary","P."],"suffixes":[]},{"propositions":[],"lastnames":["Ouyang"],"firstnames":["Ben"],"suffixes":[]},{"propositions":[],"lastnames":["MacMillan"],"firstnames":["Presley"],"suffixes":[]},{"propositions":[],"lastnames":["Ngai"],"firstnames":["Jessica"],"suffixes":[]},{"propositions":[],"lastnames":["Syed"],"firstnames":["Abdullah","Muhammad"],"suffixes":[]},{"propositions":[],"lastnames":["Sindhwani"],"firstnames":["Shrey"],"suffixes":[]},{"propositions":[],"lastnames":["Chan"],"firstnames":["Warren","C.","W."],"suffixes":[]}],"month":"September","year":"2021","note":"Publisher: American Chemical Society","pages":"14080–14094","file":"Full Text PDF:files/1767/Kingston et al. - 2021 - Specific Endothelial Cells Govern Nanoparticle Ent.pdf:application/pdf;ACS Full Text Snapshot:files/1768/acsnano.html:text/html","url_paper":"https://inbs.med.utoronto.ca/wp-content/uploads/2022/01/KINGST1.pdf","bibtex":"@article{kingston_specific_2021,\n\ttitle = {Specific {Endothelial} {Cells} {Govern} {Nanoparticle} {Entry} into {Solid} {Tumors}},\n\tvolume = {15},\n\tissn = {1936-0851},\n\turl = {https://doi.org/10.1021/acsnano.1c04510},\n\tdoi = {10.1021/acsnano.1c04510},\n\tabstract = {The successful delivery of nanoparticles to solid tumors depends on their ability to pass through blood vessels and into the tumor microenvironment. Here, we discovered a subset of tumor endothelial cells that facilitate nanoparticle transport into solid tumors. We named these cells nanoparticle transport endothelial cells (N-TECs). We show that only 21\\% of tumor endothelial cells located on a small number of vessels are involved in transporting nanoparticles into the tumor microenvironment. N-TECs have an increased expression of genes related to nanoparticle transport and vessel permeability compared to other tumor endothelial cells. The N-TECs act as gatekeepers that determine the entry point, distribution, cell accessibility, and number of nanoparticles that enter the tumor microenvironment.},\n\tnumber = {9},\n\turldate = {2021-11-06},\n\tjournal = {ACS Nano},\n\tauthor = {Kingston, Benjamin R. and Lin, Zachary P. and Ouyang, Ben and MacMillan, Presley and Ngai, Jessica and Syed, Abdullah Muhammad and Sindhwani, Shrey and Chan, Warren C. 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