Threat vigilance and intrinsic amygdala connectivity. Kirk, P. A., Holmes, A. J., & Robinson, O. J. Human Brain Mapping, 43(10):3283–3292, July, 2022. doi abstract bibtex 1 download A well-documented amygdala-dorsomedial prefrontal circuit is theorized to promote attention to threat ("threat vigilance"). Prior research has implicated a relationship between individual differences in trait anxiety/vigilance, engagement of this circuitry, and anxiogenic features of the environment (e.g., through threat-of-shock and movie-watching). In the present study, we predicted that-for those scoring high in self-reported anxiety and a behavioral measure of threat vigilance-this circuitry is chronically engaged, even in the absence of anxiogenic stimuli. Our analyses of resting-state fMRI data (N = 639) did not, however, provide evidence for such a relationship. Nevertheless, in our planned exploratory analyses, we saw a relationship between threat vigilance behavior (but not self-reported anxiety) and intrinsic amygdala-periaqueductal gray connectivity. Here, we suggest this subcortical circuitry may be chronically engaged in hypervigilant individuals, but that amygdala-prefrontal circuitry may only be engaged in response to anxiogenic stimuli.
@article{kirk_threat_2022,
title = {Threat vigilance and intrinsic amygdala connectivity},
volume = {43},
copyright = {All rights reserved},
issn = {1097-0193},
doi = {10.1002/hbm.25851},
abstract = {A well-documented amygdala-dorsomedial prefrontal circuit is theorized to promote attention to threat ("threat vigilance"). Prior research has implicated a relationship between individual differences in trait anxiety/vigilance, engagement of this circuitry, and anxiogenic features of the environment (e.g., through threat-of-shock and movie-watching). In the present study, we predicted that-for those scoring high in self-reported anxiety and a behavioral measure of threat vigilance-this circuitry is chronically engaged, even in the absence of anxiogenic stimuli. Our analyses of resting-state fMRI data (N = 639) did not, however, provide evidence for such a relationship. Nevertheless, in our planned exploratory analyses, we saw a relationship between threat vigilance behavior (but not self-reported anxiety) and intrinsic amygdala-periaqueductal gray connectivity. Here, we suggest this subcortical circuitry may be chronically engaged in hypervigilant individuals, but that amygdala-prefrontal circuitry may only be engaged in response to anxiogenic stimuli.},
language = {eng},
number = {10},
journal = {Human Brain Mapping},
author = {Kirk, Peter A. and Holmes, Avram J. and Robinson, Oliver J.},
month = jul,
year = {2022},
pmid = {35362645},
pmcid = {PMC9188965},
keywords = {*Amygdala/diagnostic imaging, *Fear/physiology, Amygdala, Anxiety, Anxiety Disorders, Anxiety/diagnostic imaging, Fear, Humans, Individuality, Magnetic Resonance Imaging, Prefrontal Cortex, Prefrontal Cortex/diagnostic imaging, amygdala, anxiety, fMRI, subcortex},
pages = {3283--3292},
}
Downloads: 1
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