@article{kitamura_anti-thyroid_2005,
	title = {Anti-thyroid hormonal activity of tetrabromobisphenol {A}, a flame retardant, and related compounds: {Affinity} to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.},
	volume = {76},
	issn = {0024-3205},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15680168},
	doi = {10.1016/j.lfs.2004.08.030},
	abstract = {The thyroid hormone-disrupting activity of tetrabromobisphenol A (TBBPA), a flame retardant, and related compounds was examined. TBBPA, tetrachlorobisphenol A (TCBPA), tetramethylbisphenol A (TMBPA) and 3,3'-dimethylbisphenol A (DMBPA) markedly inhibited the binding of triiodothyronine (T3; 1 x 10(-10) M) to thyroid hormone receptor in the concentration range of 1 x 10(-7)-1 x 10(-4) M, while bisphenol A and 2,2-diphenylpropane were inactive. TBBPA, TCBPA, TMBPA and DMBPA did not exhibit thyroid hormonal activity in a thyroid hormone-responsive reporter assay using a Chinese hamster ovary cell line (CHO-K1) transfected with thyroid hormone receptor alpha1 or beta1, but TBBPA and TCBPA showed significant anti-thyroid hormone effects on the activity of T3 (1 x 10(-8) M) in the concentration range of 3 x 10(-6) - 5 x 10(-5) M. The thyroid hormone-disrupting activity of TBBPA was also examined in terms of the effect on amphibian metamorphosis stimulated by thyroid hormone. TBBPA in the concentration range of 1 x 10(-8) to 1 x 10(-6) M showed suppressive action on T3 (5 x 10(-8) M)-enhancement of Rana rugosa tadpole tail shortening. These facts suggest that TBBPA, TCBPA, TMBPA and DMBPA can act as thyroid hormone-disrupting agents.},
	number = {14},
	journal = {Life sciences},
	author = {Kitamura, Shigeyuki and Kato, Teruhisa and Iida, Mitsuru and Jinno, Norimasa and Suzuki, Tomoharu and Ohta, Shigeru and Fujimoto, Nariaki and Hanada, Hideki and Kashiwagi, Keiko and Kashiwagi, Akihiko},
	month = feb,
	year = {2005},
	pmid = {15680168},
	keywords = {Animals, Antithyroid Agents, Antithyroid Agents: pharmacology, Biological, Biological: drug effects, CHO Cells, Chlorophenols, Chlorophenols: pharmacology, Cricetinae, Female, Flame Retardants: pharmacology, Flame retardants, Genes, Larva, Metamorphosis, Pituitary Gland, Pituitary Gland: drug effects, Pituitary Gland: metabolism, Plasmids, Plasmids: genetics, Polybrominated Biphenyls, Polybrominated Biphenyls: pharmacology, Ranidae, Rats, Receptors, Reporter, Reporter: genetics, Thyroid Hormone, Thyroid Hormone: drug effects, Thyroid Hormone: genetics, Thyroid Hormones, Thyroid Hormones: metabolism, Thyroid Hormones: pharmacology, Triiodothyronine, Triiodothyronine: pharmacology, frelec, tox},
	pages = {1589--601},
}

{"_id":"38eYPrbXyXYcDY2nZ","bibbaseid":"kitamura-kato-iida-jinno-suzuki-ohta-fujimoto-hanada-etal-antithyroidhormonalactivityoftetrabromobisphenolaaflameretardantandrelatedcompoundsaffinitytothemammalianthyroidhormonereceptorandeffectontadpolemetamorphosis-2005","author_short":["Kitamura, S.","Kato, T.","Iida, M.","Jinno, N.","Suzuki, T.","Ohta, S.","Fujimoto, N.","Hanada, H.","Kashiwagi, K.","Kashiwagi, A."],"bibdata":{"bibtype":"article","type":"article","title":"Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.","volume":"76","issn":"0024-3205","url":"http://www.ncbi.nlm.nih.gov/pubmed/15680168","doi":"10.1016/j.lfs.2004.08.030","abstract":"The thyroid hormone-disrupting activity of tetrabromobisphenol A (TBBPA), a flame retardant, and related compounds was examined. TBBPA, tetrachlorobisphenol A (TCBPA), tetramethylbisphenol A (TMBPA) and 3,3'-dimethylbisphenol A (DMBPA) markedly inhibited the binding of triiodothyronine (T3; 1 x 10(-10) M) to thyroid hormone receptor in the concentration range of 1 x 10(-7)-1 x 10(-4) M, while bisphenol A and 2,2-diphenylpropane were inactive. TBBPA, TCBPA, TMBPA and DMBPA did not exhibit thyroid hormonal activity in a thyroid hormone-responsive reporter assay using a Chinese hamster ovary cell line (CHO-K1) transfected with thyroid hormone receptor alpha1 or beta1, but TBBPA and TCBPA showed significant anti-thyroid hormone effects on the activity of T3 (1 x 10(-8) M) in the concentration range of 3 x 10(-6) - 5 x 10(-5) M. The thyroid hormone-disrupting activity of TBBPA was also examined in terms of the effect on amphibian metamorphosis stimulated by thyroid hormone. TBBPA in the concentration range of 1 x 10(-8) to 1 x 10(-6) M showed suppressive action on T3 (5 x 10(-8) M)-enhancement of Rana rugosa tadpole tail shortening. These facts suggest that TBBPA, TCBPA, TMBPA and DMBPA can act as thyroid hormone-disrupting agents.","number":"14","journal":"Life sciences","author":[{"propositions":[],"lastnames":["Kitamura"],"firstnames":["Shigeyuki"],"suffixes":[]},{"propositions":[],"lastnames":["Kato"],"firstnames":["Teruhisa"],"suffixes":[]},{"propositions":[],"lastnames":["Iida"],"firstnames":["Mitsuru"],"suffixes":[]},{"propositions":[],"lastnames":["Jinno"],"firstnames":["Norimasa"],"suffixes":[]},{"propositions":[],"lastnames":["Suzuki"],"firstnames":["Tomoharu"],"suffixes":[]},{"propositions":[],"lastnames":["Ohta"],"firstnames":["Shigeru"],"suffixes":[]},{"propositions":[],"lastnames":["Fujimoto"],"firstnames":["Nariaki"],"suffixes":[]},{"propositions":[],"lastnames":["Hanada"],"firstnames":["Hideki"],"suffixes":[]},{"propositions":[],"lastnames":["Kashiwagi"],"firstnames":["Keiko"],"suffixes":[]},{"propositions":[],"lastnames":["Kashiwagi"],"firstnames":["Akihiko"],"suffixes":[]}],"month":"February","year":"2005","pmid":"15680168","keywords":"Animals, Antithyroid Agents, Antithyroid Agents: pharmacology, Biological, Biological: drug effects, CHO Cells, Chlorophenols, Chlorophenols: pharmacology, Cricetinae, Female, Flame Retardants: pharmacology, Flame retardants, Genes, Larva, Metamorphosis, Pituitary Gland, Pituitary Gland: drug effects, Pituitary Gland: metabolism, Plasmids, Plasmids: genetics, Polybrominated Biphenyls, Polybrominated Biphenyls: pharmacology, Ranidae, Rats, Receptors, Reporter, Reporter: genetics, Thyroid Hormone, Thyroid Hormone: drug effects, Thyroid Hormone: genetics, Thyroid Hormones, Thyroid Hormones: metabolism, Thyroid Hormones: pharmacology, Triiodothyronine, Triiodothyronine: pharmacology, frelec, tox","pages":"1589–601","bibtex":"@article{kitamura_anti-thyroid_2005,\n\ttitle = {Anti-thyroid hormonal activity of tetrabromobisphenol {A}, a flame retardant, and related compounds: {Affinity} to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.},\n\tvolume = {76},\n\tissn = {0024-3205},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/15680168},\n\tdoi = {10.1016/j.lfs.2004.08.030},\n\tabstract = {The thyroid hormone-disrupting activity of tetrabromobisphenol A (TBBPA), a flame retardant, and related compounds was examined. TBBPA, tetrachlorobisphenol A (TCBPA), tetramethylbisphenol A (TMBPA) and 3,3'-dimethylbisphenol A (DMBPA) markedly inhibited the binding of triiodothyronine (T3; 1 x 10(-10) M) to thyroid hormone receptor in the concentration range of 1 x 10(-7)-1 x 10(-4) M, while bisphenol A and 2,2-diphenylpropane were inactive. TBBPA, TCBPA, TMBPA and DMBPA did not exhibit thyroid hormonal activity in a thyroid hormone-responsive reporter assay using a Chinese hamster ovary cell line (CHO-K1) transfected with thyroid hormone receptor alpha1 or beta1, but TBBPA and TCBPA showed significant anti-thyroid hormone effects on the activity of T3 (1 x 10(-8) M) in the concentration range of 3 x 10(-6) - 5 x 10(-5) M. The thyroid hormone-disrupting activity of TBBPA was also examined in terms of the effect on amphibian metamorphosis stimulated by thyroid hormone. TBBPA in the concentration range of 1 x 10(-8) to 1 x 10(-6) M showed suppressive action on T3 (5 x 10(-8) M)-enhancement of Rana rugosa tadpole tail shortening. These facts suggest that TBBPA, TCBPA, TMBPA and DMBPA can act as thyroid hormone-disrupting agents.},\n\tnumber = {14},\n\tjournal = {Life sciences},\n\tauthor = {Kitamura, Shigeyuki and Kato, Teruhisa and Iida, Mitsuru and Jinno, Norimasa and Suzuki, Tomoharu and Ohta, Shigeru and Fujimoto, Nariaki and Hanada, Hideki and Kashiwagi, Keiko and Kashiwagi, Akihiko},\n\tmonth = feb,\n\tyear = {2005},\n\tpmid = {15680168},\n\tkeywords = {Animals, Antithyroid Agents, Antithyroid Agents: pharmacology, Biological, Biological: drug effects, CHO Cells, Chlorophenols, Chlorophenols: pharmacology, Cricetinae, Female, Flame Retardants: pharmacology, Flame retardants, Genes, Larva, Metamorphosis, Pituitary Gland, Pituitary Gland: drug effects, Pituitary Gland: metabolism, Plasmids, Plasmids: genetics, Polybrominated Biphenyls, Polybrominated Biphenyls: pharmacology, Ranidae, Rats, Receptors, Reporter, Reporter: genetics, Thyroid Hormone, Thyroid Hormone: drug effects, Thyroid Hormone: genetics, Thyroid Hormones, Thyroid Hormones: metabolism, Thyroid Hormones: pharmacology, Triiodothyronine, Triiodothyronine: pharmacology, frelec, tox},\n\tpages = {1589--601},\n}\n\n\n\n","author_short":["Kitamura, S.","Kato, T.","Iida, M.","Jinno, N.","Suzuki, T.","Ohta, S.","Fujimoto, N.","Hanada, H.","Kashiwagi, K.","Kashiwagi, A."],"key":"kitamura_anti-thyroid_2005","id":"kitamura_anti-thyroid_2005","bibbaseid":"kitamura-kato-iida-jinno-suzuki-ohta-fujimoto-hanada-etal-antithyroidhormonalactivityoftetrabromobisphenolaaflameretardantandrelatedcompoundsaffinitytothemammalianthyroidhormonereceptorandeffectontadpolemetamorphosis-2005","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/15680168"},"keyword":["Animals","Antithyroid Agents","Antithyroid Agents: pharmacology","Biological","Biological: drug effects","CHO Cells","Chlorophenols","Chlorophenols: pharmacology","Cricetinae","Female","Flame Retardants: pharmacology","Flame retardants","Genes","Larva","Metamorphosis","Pituitary Gland","Pituitary Gland: drug effects","Pituitary Gland: metabolism","Plasmids","Plasmids: genetics","Polybrominated Biphenyls","Polybrominated Biphenyls: pharmacology","Ranidae","Rats","Receptors","Reporter","Reporter: genetics","Thyroid Hormone","Thyroid Hormone: drug effects","Thyroid Hormone: genetics","Thyroid Hormones","Thyroid Hormones: metabolism","Thyroid Hormones: pharmacology","Triiodothyronine","Triiodothyronine: pharmacology","frelec","tox"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/mdedeo","dataSources":["SSfxPwd7XbkRtnZ9f"],"keywords":["animals","antithyroid agents","antithyroid agents: pharmacology","biological","biological: drug effects","cho cells","chlorophenols","chlorophenols: pharmacology","cricetinae","female","flame retardants: pharmacology","flame retardants","genes","larva","metamorphosis","pituitary gland","pituitary gland: drug effects","pituitary gland: metabolism","plasmids","plasmids: genetics","polybrominated biphenyls","polybrominated biphenyls: pharmacology","ranidae","rats","receptors","reporter","reporter: genetics","thyroid hormone","thyroid hormone: drug effects","thyroid hormone: genetics","thyroid hormones","thyroid hormones: metabolism","thyroid hormones: pharmacology","triiodothyronine","triiodothyronine: pharmacology","frelec","tox"],"search_terms":["anti","thyroid","hormonal","activity","tetrabromobisphenol","flame","retardant","related","compounds","affinity","mammalian","thyroid","hormone","receptor","effect","tadpole","metamorphosis","kitamura","kato","iida","jinno","suzuki","ohta","fujimoto","hanada","kashiwagi","kashiwagi"],"title":"Anti-thyroid hormonal activity of tetrabromobisphenol A, a flame retardant, and related compounds: Affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.","year":2005}