@article{ Klausberger_Buzsaki03,
  author = {Klausberger, T. and Magill, P.J. and Marton, L.F. and Roberts, J.D.
	and Cobden, P.M. and Buzsaki, G. and Somogyi, P.},
  title = {{{B}rain-state- and cell-type-specific firing of hippocampal interneurons
	in vivo}},
  journal = {Nature},
  year = {2003},
  volume = {421},
  pages = {844--848},
  month = {Feb},
  abstract = {Neural-network oscillations at distinct frequencies have been implicated
	in the encoding, consolidation and retrieval of information in the
	hippocampus. Some GABA (gamma-aminobutyric acid)-containing interneurons
	fire phase-locked to theta oscillations (4-8 Hz) or to sharp-wave-associated
	ripple oscillations (120-200 Hz), which represent different behavioural
	states. Interneurons also entrain pyramidal cells in vitro. The large
	diversity of interneurons poses the question of whether they have
	specific roles in shaping distinct network activities in vivo. Here
	we report that three distinct interneuron types--basket, axo-axonic
	and oriens-lacunosum-moleculare cells--visualized and defined by
	synaptic connectivity as well as by neurochemical markers, contribute
	differentially to theta and ripple oscillations in anaesthetized
	rats. The firing patterns of individual cells of the same class are
	remarkably stereotyped and provide unique signatures for each class.
	We conclude that the diversity of interneurons, innervating distinct
	domains of pyramidal cells, emerged to coordinate the activity of
	pyramidal cells in a temporally distinct and brain-state-dependent
	manner.}
}

{"_id":"HqHyjBSwE3wYwtiBC","bibbaseid":"klausberger-magill-marton-roberts-cobden-buzsaki-somogyi-brainstateandcelltypespecificfiringofhippocampalinterneuronsinvivo-2003","downloads":0,"creationDate":"2015-02-08T05:14:48.017Z","title":"Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo","author_short":["Klausberger, T.","Magill, P.","Marton, L.","Roberts, J.","Cobden, P.","Buzsaki, G.","Somogyi, P."],"year":2003,"bibtype":"article","biburl":"http://cnslab.mb.jhu.edu/niebase.bib","bibdata":{"abstract":"Neural-network oscillations at distinct frequencies have been implicated in the encoding, consolidation and retrieval of information in the hippocampus. Some GABA (gamma-aminobutyric acid)-containing interneurons fire phase-locked to theta oscillations (4-8 Hz) or to sharp-wave-associated ripple oscillations (120-200 Hz), which represent different behavioural states. Interneurons also entrain pyramidal cells in vitro. The large diversity of interneurons poses the question of whether they have specific roles in shaping distinct network activities in vivo. Here we report that three distinct interneuron types--basket, axo-axonic and oriens-lacunosum-moleculare cells--visualized and defined by synaptic connectivity as well as by neurochemical markers, contribute differentially to theta and ripple oscillations in anaesthetized rats. The firing patterns of individual cells of the same class are remarkably stereotyped and provide unique signatures for each class. We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner.","author":["Klausberger, T.","Magill, P.J.","Marton, L.F.","Roberts, J.D.","Cobden, P.M.","Buzsaki, G.","Somogyi, P."],"author_short":["Klausberger, T.","Magill, P.","Marton, L.","Roberts, J.","Cobden, P.","Buzsaki, G.","Somogyi, P."],"bibtex":"@article{ Klausberger_Buzsaki03,\n author = {Klausberger, T. and Magill, P.J. and Marton, L.F. and Roberts, J.D.\n\tand Cobden, P.M. and Buzsaki, G. and Somogyi, P.},\n title = {{{B}rain-state- and cell-type-specific firing of hippocampal interneurons\n\tin vivo}},\n journal = {Nature},\n year = {2003},\n volume = {421},\n pages = {844--848},\n month = {Feb},\n abstract = {Neural-network oscillations at distinct frequencies have been implicated\n\tin the encoding, consolidation and retrieval of information in the\n\thippocampus. Some GABA (gamma-aminobutyric acid)-containing interneurons\n\tfire phase-locked to theta oscillations (4-8 Hz) or to sharp-wave-associated\n\tripple oscillations (120-200 Hz), which represent different behavioural\n\tstates. Interneurons also entrain pyramidal cells in vitro. The large\n\tdiversity of interneurons poses the question of whether they have\n\tspecific roles in shaping distinct network activities in vivo. Here\n\twe report that three distinct interneuron types--basket, axo-axonic\n\tand oriens-lacunosum-moleculare cells--visualized and defined by\n\tsynaptic connectivity as well as by neurochemical markers, contribute\n\tdifferentially to theta and ripple oscillations in anaesthetized\n\trats. The firing patterns of individual cells of the same class are\n\tremarkably stereotyped and provide unique signatures for each class.\n\tWe conclude that the diversity of interneurons, innervating distinct\n\tdomains of pyramidal cells, emerged to coordinate the activity of\n\tpyramidal cells in a temporally distinct and brain-state-dependent\n\tmanner.}\n}","bibtype":"article","id":"Klausberger_Buzsaki03","journal":"Nature","key":"Klausberger_Buzsaki03","month":"Feb","pages":"844--848","title":"Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo","type":"article","volume":"421","year":"2003","bibbaseid":"klausberger-magill-marton-roberts-cobden-buzsaki-somogyi-brainstateandcelltypespecificfiringofhippocampalinterneuronsinvivo-2003","role":"author","urls":{},"downloads":0},"search_terms":["brain","state","cell","type","specific","firing","hippocampal","interneurons","vivo","klausberger","magill","marton","roberts","cobden","buzsaki","somogyi"],"keywords":[],"authorIDs":[],"dataSources":["ErLXoH8mqSjESnrN5"]}