Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies. Kleo, K., Jovanovic, V. M., Arndold, A., Lehmann, A., Lammert, H., Berg, E., Harloff, H., Treese, C., Hummel, M., & Daum, S. Journal of Cancer Research and Clinical Oncology, March, 2022.
Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies [link]Paper  doi  abstract   bibtex   6 downloads  
Perioperative chemo-(radio-) therapy is the accepted standard in European patients with locally advanced adenocarcinoma of the esophagogastric junction or stomach (AEG/AS). However, 30–85% of patients do not respond to this treatment. The aim of our study was the identification of predictive biomarkers in pre-therapeutic endoscopic tumor biopsies from patients with histopathologic response (Becker-1) versus non-response (Becker-2/3) to preoperative chemotherapy.
@article{kleo_response_2022,
	title = {Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies},
	issn = {1432-1335},
	url = {https://doi.org/10.1007/s00432-022-03944-z},
	doi = {10.1007/s00432-022-03944-z},
	abstract = {Perioperative chemo-(radio-) therapy is the accepted standard in European patients with locally advanced adenocarcinoma of the esophagogastric junction or stomach (AEG/AS). However, 30–85\% of patients do not respond to this treatment. The aim of our study was the identification of predictive biomarkers in pre-therapeutic endoscopic tumor biopsies from patients with histopathologic response (Becker-1) versus non-response (Becker-2/3) to preoperative chemotherapy.},
	language = {en},
	urldate = {2022-03-15},
	journal = {Journal of Cancer Research and Clinical Oncology},
	author = {Kleo, Karsten and Jovanovic, Vladimir M. and Arndold, Alexander and Lehmann, Annika and Lammert, Hedwig and Berg, Erika and Harloff, Hannah and Treese, Christoph and Hummel, Michael and Daum, Severin},
	month = mar,
	year = {2022},
	keywords = {SOPHiA DDM},
}

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