Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States. Klevens, R. M., Morrison, M. A., Nadle, J., Petit, S., Gershman, K., Ray, S., Harrison, L. H., Lynfield, R., Dumyati, G., Townes, J. M., Craig, A. S., Zell, E. R., Fosheim, G. E., McDougal, L. K., Carey, R. B., Fridkin, S. K., & for the Active Bacterial Core surveillance (ABCs) MRSA Investigators JAMA: The Journal of the American Medical Association, 298(15):1763 --1771, October, 2007. ![Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Context As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed.Objectives To describe the incidence and distribution of invasive MRSA disease in 9 US communities and to estimate the burden of invasive MRSA infections in the United States in 2005.Design and Setting Active, population-based surveillance for invasive MRSA in 9 sites participating in the Active Bacterial Core surveillance (ABCs)/Emerging Infections Program Network from July 2004 through December 2005. Reports of MRSA were investigated and classified as either health care–associated (either hospital-onset or community-onset) or community-associated (patients without established health care risk factors for MRSA).Main Outcome Measures Incidence rates and estimated number of invasive MRSA infections and in-hospital deaths among patients with MRSA in the United States in 2005; interval estimates of incidence excluding 1 site that appeared to be an outlier with the highest incidence; molecular characterization of infecting strains.Results There were 8987 observed cases of invasive MRSA reported during the surveillance period. Most MRSA infections were health care–associated: 5250 (58.4%) were community-onset infections, 2389 (26.6%) were hospital-onset infections; 1234 (13.7%) were community-associated infections, and 114 (1.3%) could not be classified. In 2005, the standardized incidence rate of invasive MRSA was 31.8 per 100 000 (interval estimate, 24.4-35.2). Incidence rates were highest among persons 65 years and older (127.7 per 100 000; interval estimate, 92.6-156.9), blacks (66.5 per 100 000; interval estimate, 43.5-63.1), and males (37.5 per 100 000; interval estimate, 26.8-39.5). There were 1598 in-hospital deaths among patients with MRSA infection during the surveillance period. In 2005, the standardized mortality rate was 6.3 per 100 000 (interval estimate, 3.3-7.5). Molecular testing identified strains historically associated with community-associated disease outbreaks recovered from cultures in both hospital-onset and community-onset health care–associated infections in all surveillance areas.Conclusions Invasive MRSA infection affects certain populations disproportionately. It is a major public health problem primarily related to health care but no longer confined to intensive care units, acute care hospitals, or any health care institution.
@article{klevens_invasive_2007,
abstract = {Context As the epidemiology of infections with methicillin-resistant Staphylococcus aureus {(MRSA)} changes, accurate information on the scope and magnitude of {MRSA} infections in the {US} population is {needed.Objectives} To describe the incidence and distribution of invasive {MRSA} disease in 9 {US} communities and to estimate the burden of invasive {MRSA} infections in the United States in {2005.Design} and Setting Active, population-based surveillance for invasive {MRSA} in 9 sites participating in the Active Bacterial Core surveillance {(ABCs)/Emerging} Infections Program Network from July 2004 through December 2005. Reports of {MRSA} were investigated and classified as either health care–associated (either hospital-onset or community-onset) or community-associated (patients without established health care risk factors for {MRSA).Main} Outcome Measures Incidence rates and estimated number of invasive {MRSA} infections and in-hospital deaths among patients with {MRSA} in the United States in 2005; interval estimates of incidence excluding 1 site that appeared to be an outlier with the highest incidence; molecular characterization of infecting {strains.Results} There were 8987 observed cases of invasive {MRSA} reported during the surveillance period. Most {MRSA} infections were health care–associated: 5250 (58.4\%) were community-onset infections, 2389 (26.6\%) were hospital-onset infections; 1234 (13.7\%) were community-associated infections, and 114 (1.3\%) could not be classified. In 2005, the standardized incidence rate of invasive {MRSA} was 31.8 per 100 000 (interval estimate, 24.4-35.2). Incidence rates were highest among persons 65 years and older (127.7 per 100 000; interval estimate, 92.6-156.9), blacks (66.5 per 100 000; interval estimate, 43.5-63.1), and males (37.5 per 100 000; interval estimate, 26.8-39.5). There were 1598 in-hospital deaths among patients with {MRSA} infection during the surveillance period. In 2005, the standardized mortality rate was 6.3 per 100 000 (interval estimate, 3.3-7.5). Molecular testing identified strains historically associated with community-associated disease outbreaks recovered from cultures in both hospital-onset and community-onset health care–associated infections in all surveillance {areas.Conclusions} Invasive {MRSA} infection affects certain populations disproportionately. It is a major public health problem primarily related to health care but no longer confined to intensive care units, acute care hospitals, or any health care institution.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Klevens, R. Monina and Morrison, Melissa A. and Nadle, Joelle and Petit, Susan and Gershman, Ken and Ray, Susan and Harrison, Lee H. and Lynfield, Ruth and Dumyati, Ghinwa and Townes, John M. and Craig, Allen S. and Zell, Elizabeth R. and Fosheim, Gregory E. and {McDougal}, Linda K. and Carey, Roberta B. and Fridkin, Scott K. and for the Active Bacterial Core surveillance {(ABCs)} {MRSA} Investigators},
biburl = {http://www.bibsonomy.org/bibtex/21052b19d2e3d098b58e2c662e4a9efb8/jelias},
doi = {10.1001/jama.298.15.1763},
interhash = {3c9c108dee5b27d9c912ee746a743958},
intrahash = {1052b19d2e3d098b58e2c662e4a9efb8},
journal = {{JAMA:} The Journal of the American Medical Association},
keywords = {imported},
month = oct,
number = 15,
pages = {1763 --1771},
timestamp = {2011-09-22T16:46:53.000+0200},
title = {Invasive {Methicillin-Resistant} Staphylococcus aureus Infections in the United States},
url = {http://jama.ama-assn.org/content/298/15/1763.abstract},
volume = 298,
year = 2007
}
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K.","for the Active Bacterial Core surveillance (ABCs) MRSA Investigators"],"year":2007,"bibtype":"article","biburl":"http://www.bibsonomy.org/bib/author/activity?items=1000","bibdata":{"bibtype":"article","type":"article","abstract":"Context As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed.Objectives To describe the incidence and distribution of invasive MRSA disease in 9 US communities and to estimate the burden of invasive MRSA infections in the United States in 2005.Design and Setting Active, population-based surveillance for invasive MRSA in 9 sites participating in the Active Bacterial Core surveillance (ABCs)/Emerging Infections Program Network from July 2004 through December 2005. Reports of MRSA were investigated and classified as either health care–associated (either hospital-onset or community-onset) or community-associated (patients without established health care risk factors for MRSA).Main Outcome Measures Incidence rates and estimated number of invasive MRSA infections and in-hospital deaths among patients with MRSA in the United States in 2005; interval estimates of incidence excluding 1 site that appeared to be an outlier with the highest incidence; molecular characterization of infecting strains.Results There were 8987 observed cases of invasive MRSA reported during the surveillance period. Most MRSA infections were health care–associated: 5250 (58.4%) were community-onset infections, 2389 (26.6%) were hospital-onset infections; 1234 (13.7%) were community-associated infections, and 114 (1.3%) could not be classified. In 2005, the standardized incidence rate of invasive MRSA was 31.8 per 100 000 (interval estimate, 24.4-35.2). Incidence rates were highest among persons 65 years and older (127.7 per 100 000; interval estimate, 92.6-156.9), blacks (66.5 per 100 000; interval estimate, 43.5-63.1), and males (37.5 per 100 000; interval estimate, 26.8-39.5). There were 1598 in-hospital deaths among patients with MRSA infection during the surveillance period. In 2005, the standardized mortality rate was 6.3 per 100 000 (interval estimate, 3.3-7.5). Molecular testing identified strains historically associated with community-associated disease outbreaks recovered from cultures in both hospital-onset and community-onset health care–associated infections in all surveillance areas.Conclusions Invasive MRSA infection affects certain populations disproportionately. It is a major public health problem primarily related to health care but no longer confined to intensive care units, acute care hospitals, or any health care institution.","added-at":"2011-03-11T10:05:34.000+0100","author":[{"propositions":[],"lastnames":["Klevens"],"firstnames":["R.","Monina"],"suffixes":[]},{"propositions":[],"lastnames":["Morrison"],"firstnames":["Melissa","A."],"suffixes":[]},{"propositions":[],"lastnames":["Nadle"],"firstnames":["Joelle"],"suffixes":[]},{"propositions":[],"lastnames":["Petit"],"firstnames":["Susan"],"suffixes":[]},{"propositions":[],"lastnames":["Gershman"],"firstnames":["Ken"],"suffixes":[]},{"propositions":[],"lastnames":["Ray"],"firstnames":["Susan"],"suffixes":[]},{"propositions":[],"lastnames":["Harrison"],"firstnames":["Lee","H."],"suffixes":[]},{"propositions":[],"lastnames":["Lynfield"],"firstnames":["Ruth"],"suffixes":[]},{"propositions":[],"lastnames":["Dumyati"],"firstnames":["Ghinwa"],"suffixes":[]},{"propositions":[],"lastnames":["Townes"],"firstnames":["John","M."],"suffixes":[]},{"propositions":[],"lastnames":["Craig"],"firstnames":["Allen","S."],"suffixes":[]},{"propositions":[],"lastnames":["Zell"],"firstnames":["Elizabeth","R."],"suffixes":[]},{"propositions":[],"lastnames":["Fosheim"],"firstnames":["Gregory","E."],"suffixes":[]},{"propositions":[],"lastnames":["McDougal"],"firstnames":["Linda","K."],"suffixes":[]},{"propositions":[],"lastnames":["Carey"],"firstnames":["Roberta","B."],"suffixes":[]},{"propositions":[],"lastnames":["Fridkin"],"firstnames":["Scott","K."],"suffixes":[]},{"firstnames":[],"propositions":["for","the","Active","Bacterial","Core","surveillance"],"lastnames":["(ABCs)","MRSA","Investigators"],"suffixes":[]}],"biburl":"http://www.bibsonomy.org/bibtex/21052b19d2e3d098b58e2c662e4a9efb8/jelias","doi":"10.1001/jama.298.15.1763","interhash":"3c9c108dee5b27d9c912ee746a743958","intrahash":"1052b19d2e3d098b58e2c662e4a9efb8","journal":"JAMA: The Journal of the American Medical Association","keywords":"imported","month":"October","number":"15","pages":"1763 --1771","timestamp":"2011-09-22T16:46:53.000+0200","title":"Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States","url":"http://jama.ama-assn.org/content/298/15/1763.abstract","volume":"298","year":"2007","bibtex":"@article{klevens_invasive_2007,\n abstract = {Context As the epidemiology of infections with methicillin-resistant Staphylococcus aureus {(MRSA)} changes, accurate information on the scope and magnitude of {MRSA} infections in the {US} population is {needed.Objectives} To describe the incidence and distribution of invasive {MRSA} disease in 9 {US} communities and to estimate the burden of invasive {MRSA} infections in the United States in {2005.Design} and Setting Active, population-based surveillance for invasive {MRSA} in 9 sites participating in the Active Bacterial Core surveillance {(ABCs)/Emerging} Infections Program Network from July 2004 through December 2005. Reports of {MRSA} were investigated and classified as either health care–associated (either hospital-onset or community-onset) or community-associated (patients without established health care risk factors for {MRSA).Main} Outcome Measures Incidence rates and estimated number of invasive {MRSA} infections and in-hospital deaths among patients with {MRSA} in the United States in 2005; interval estimates of incidence excluding 1 site that appeared to be an outlier with the highest incidence; molecular characterization of infecting {strains.Results} There were 8987 observed cases of invasive {MRSA} reported during the surveillance period. Most {MRSA} infections were health care–associated: 5250 (58.4\\%) were community-onset infections, 2389 (26.6\\%) were hospital-onset infections; 1234 (13.7\\%) were community-associated infections, and 114 (1.3\\%) could not be classified. In 2005, the standardized incidence rate of invasive {MRSA} was 31.8 per 100 000 (interval estimate, 24.4-35.2). Incidence rates were highest among persons 65 years and older (127.7 per 100 000; interval estimate, 92.6-156.9), blacks (66.5 per 100 000; interval estimate, 43.5-63.1), and males (37.5 per 100 000; interval estimate, 26.8-39.5). There were 1598 in-hospital deaths among patients with {MRSA} infection during the surveillance period. In 2005, the standardized mortality rate was 6.3 per 100 000 (interval estimate, 3.3-7.5). Molecular testing identified strains historically associated with community-associated disease outbreaks recovered from cultures in both hospital-onset and community-onset health care–associated infections in all surveillance {areas.Conclusions} Invasive {MRSA} infection affects certain populations disproportionately. It is a major public health problem primarily related to health care but no longer confined to intensive care units, acute care hospitals, or any health care institution.},\n added-at = {2011-03-11T10:05:34.000+0100},\n author = {Klevens, R. Monina and Morrison, Melissa A. and Nadle, Joelle and Petit, Susan and Gershman, Ken and Ray, Susan and Harrison, Lee H. and Lynfield, Ruth and Dumyati, Ghinwa and Townes, John M. and Craig, Allen S. and Zell, Elizabeth R. and Fosheim, Gregory E. and {McDougal}, Linda K. and Carey, Roberta B. and Fridkin, Scott K. and for the Active Bacterial Core surveillance {(ABCs)} {MRSA} Investigators},\n biburl = {http://www.bibsonomy.org/bibtex/21052b19d2e3d098b58e2c662e4a9efb8/jelias},\n doi = {10.1001/jama.298.15.1763},\n interhash = {3c9c108dee5b27d9c912ee746a743958},\n intrahash = {1052b19d2e3d098b58e2c662e4a9efb8},\n journal = {{JAMA:} The Journal of the American Medical Association},\n keywords = {imported},\n month = oct,\n number = 15,\n pages = {1763 --1771},\n timestamp = {2011-09-22T16:46:53.000+0200},\n title = {Invasive {Methicillin-Resistant} Staphylococcus aureus Infections in the United States},\n url = {http://jama.ama-assn.org/content/298/15/1763.abstract},\n volume = 298,\n year = 2007\n}\n\n","author_short":["Klevens, R. 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