Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure. Klingenheben, T., Zabel, M., D'Agostino, R., B., Cohen, R., J., & Hohnloser, S., H. Lancet, 356(9230):651-2, 2000.
Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure. [pdf]Paper  Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure. [link]Website  abstract   bibtex   
Measurement of microvolt level T-wave alternans in the surface electrocardiogram is a novel way to assess the risk of ventricular arrhythmias. Seven tests of arrhythmic risk, including T-wave alternans, were undertaken in 107 consecutive patients with congestive heart failure and no history of sustained ventricular arrhythmias; the patients were followed up for arrhythmic events during the next 18 months. Of the patients with events, 11 had positive and two indeterminate T-wave alternans results; there were no arrhythmic events among patients with negative T-wave alternans results. Of the seven tests, only T-wave alternans was a significant (p=0.0036) and independent predictor of arrhythmic events.

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