@article{RN325,
   author = {Klinkhammer, S. and Horn, J. and Duits, A. A. and Visser-Meily, J. M. A. and Verwijk, E. and Slooter, A. J. C. and Postma, A. A. and van Heugten, C. M. and NeNe, SCo study group},
   title = {Neurological and (neuro)psychological sequelae in intensive care and general ward COVID-19 survivors},
   journal = {Eur J Neurol},
   note = {Klinkhammer, Simona
Horn, Janneke
Duits, Annelien A
Visser-Meily, Johanna M A
Verwijk, Esmee
Slooter, Arjen J C
Postma, Alida A
van Heugten, Caroline M
eng
England
Eur J Neurol. 2023 Apr 3. doi: 10.1111/ene.15812.},
   abstract = {BACKGROUND: COVID-19 affects the brain, leading to long-term complaints. Studies combining brain abnormalities with objective and subjective consequences are lacking. We investigated long-term structural brain abnormalities, neurological-, and (neuro)psychological consequences in COVID-19 patients admitted to the intensive care unit (ICU) or general ward. We aimed to create a multidisciplinary view on the impact of severe COVID-19 on functioning and to compare long-term consequences between ICU and general ward patients. METHODS: This multicentre prospective cohort study assessed brain abnormalities (3T MRI), cognitive dysfunction (neuropsychological test battery), neurological symptoms, cognitive complaints, emotional distress, and wellbeing (self-report questionnaires) in ICU and general ward (non-ICU) survivors. RESULTS: 101 ICU and 104 non-ICU patients participated 8-10 months post-hospital discharge. Significantly more ICU patients exhibited cerebral microbleeds (61% versus 32%,p<0.001) and had higher numbers of microbleeds (p<0.001). No group differences were found in cognitive dysfunction, neurological symptoms, cognitive complaints, emotional distress, or wellbeing. The number of microbleeds did not predict cognitive dysfunction. In the complete sample, cognitive screening suggested cognitive dysfunction in 41%, standard neuropsychological testing showed cognitive dysfunction in 12%. Sixty-two% reported >/=3 cognitive complaints. Clinically relevant scores of depression, anxiety, and post-traumatic stress were found in 15%, 19%, and 12%, respectively. Twenty-eight% experienced insomnia and 51% severe fatigue. CONCLUSION: COVID-19 ICU survivors had a higher prevalence for microbleeds but not for cognitive dysfunction compared to general ward survivors. Self-reported symptoms exceeded cognitive dysfunction. Cognitive complaints, neurological symptoms, and severe fatigue were frequently reported in both groups, fitting the post-COVID-19 syndrome.},
   keywords = {SARS-CoV-2
brain damage
cognitive, affective},
   ISSN = {1468-1331 (Electronic)
1351-5101 (Linking)},
   DOI = {10.1111/ene.15812},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/37010152},
   year = {2023},
   type = {Journal Article}
}

{"_id":"sdcLnREGpFPY3NWMC","bibbaseid":"klinkhammer-horn-duits-vissermeily-verwijk-slooter-postma-vanheugten-etal-neurologicalandneuropsychologicalsequelaeinintensivecareandgeneralwardcovid19survivors-2023","author_short":["Klinkhammer, S.","Horn, J.","Duits, A. A.","Visser-Meily, J. M. A.","Verwijk, E.","Slooter, A. J. C.","Postma, A. A.","van Heugten, C. M.","NeNe, S. s. g."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Klinkhammer"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Horn"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Duits"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Visser-Meily"],"firstnames":["J.","M.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Verwijk"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Slooter"],"firstnames":["A.","J.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Heugten"],"firstnames":["C.","M."],"suffixes":[]},{"propositions":[],"lastnames":["NeNe"],"firstnames":["SCo","study","group"],"suffixes":[]}],"title":"Neurological and (neuro)psychological sequelae in intensive care and general ward COVID-19 survivors","journal":"Eur J Neurol","note":"Klinkhammer, Simona Horn, Janneke Duits, Annelien A Visser-Meily, Johanna M A Verwijk, Esmee Slooter, Arjen J C Postma, Alida A van Heugten, Caroline M eng England Eur J Neurol. 2023 Apr 3. doi: 10.1111/ene.15812.","abstract":"BACKGROUND: COVID-19 affects the brain, leading to long-term complaints. Studies combining brain abnormalities with objective and subjective consequences are lacking. We investigated long-term structural brain abnormalities, neurological-, and (neuro)psychological consequences in COVID-19 patients admitted to the intensive care unit (ICU) or general ward. We aimed to create a multidisciplinary view on the impact of severe COVID-19 on functioning and to compare long-term consequences between ICU and general ward patients. METHODS: This multicentre prospective cohort study assessed brain abnormalities (3T MRI), cognitive dysfunction (neuropsychological test battery), neurological symptoms, cognitive complaints, emotional distress, and wellbeing (self-report questionnaires) in ICU and general ward (non-ICU) survivors. RESULTS: 101 ICU and 104 non-ICU patients participated 8-10 months post-hospital discharge. Significantly more ICU patients exhibited cerebral microbleeds (61% versus 32%,p<0.001) and had higher numbers of microbleeds (p<0.001). No group differences were found in cognitive dysfunction, neurological symptoms, cognitive complaints, emotional distress, or wellbeing. The number of microbleeds did not predict cognitive dysfunction. In the complete sample, cognitive screening suggested cognitive dysfunction in 41%, standard neuropsychological testing showed cognitive dysfunction in 12%. Sixty-two% reported >/=3 cognitive complaints. Clinically relevant scores of depression, anxiety, and post-traumatic stress were found in 15%, 19%, and 12%, respectively. Twenty-eight% experienced insomnia and 51% severe fatigue. CONCLUSION: COVID-19 ICU survivors had a higher prevalence for microbleeds but not for cognitive dysfunction compared to general ward survivors. Self-reported symptoms exceeded cognitive dysfunction. Cognitive complaints, neurological symptoms, and severe fatigue were frequently reported in both groups, fitting the post-COVID-19 syndrome.","keywords":"SARS-CoV-2 brain damage cognitive, affective","issn":"1468-1331 (Electronic) 1351-5101 (Linking)","doi":"10.1111/ene.15812","url":"https://www.ncbi.nlm.nih.gov/pubmed/37010152","year":"2023","bibtex":"@article{RN325,\n author = {Klinkhammer, S. and Horn, J. and Duits, A. A. and Visser-Meily, J. M. A. and Verwijk, E. and Slooter, A. J. C. and Postma, A. A. and van Heugten, C. M. and NeNe, SCo study group},\n title = {Neurological and (neuro)psychological sequelae in intensive care and general ward COVID-19 survivors},\n journal = {Eur J Neurol},\n note = {Klinkhammer, Simona\nHorn, Janneke\nDuits, Annelien A\nVisser-Meily, Johanna M A\nVerwijk, Esmee\nSlooter, Arjen J C\nPostma, Alida A\nvan Heugten, Caroline M\neng\nEngland\nEur J Neurol. 2023 Apr 3. doi: 10.1111/ene.15812.},\n abstract = {BACKGROUND: COVID-19 affects the brain, leading to long-term complaints. Studies combining brain abnormalities with objective and subjective consequences are lacking. We investigated long-term structural brain abnormalities, neurological-, and (neuro)psychological consequences in COVID-19 patients admitted to the intensive care unit (ICU) or general ward. We aimed to create a multidisciplinary view on the impact of severe COVID-19 on functioning and to compare long-term consequences between ICU and general ward patients. METHODS: This multicentre prospective cohort study assessed brain abnormalities (3T MRI), cognitive dysfunction (neuropsychological test battery), neurological symptoms, cognitive complaints, emotional distress, and wellbeing (self-report questionnaires) in ICU and general ward (non-ICU) survivors. RESULTS: 101 ICU and 104 non-ICU patients participated 8-10 months post-hospital discharge. Significantly more ICU patients exhibited cerebral microbleeds (61% versus 32%,p<0.001) and had higher numbers of microbleeds (p<0.001). No group differences were found in cognitive dysfunction, neurological symptoms, cognitive complaints, emotional distress, or wellbeing. The number of microbleeds did not predict cognitive dysfunction. In the complete sample, cognitive screening suggested cognitive dysfunction in 41%, standard neuropsychological testing showed cognitive dysfunction in 12%. Sixty-two% reported >/=3 cognitive complaints. Clinically relevant scores of depression, anxiety, and post-traumatic stress were found in 15%, 19%, and 12%, respectively. Twenty-eight% experienced insomnia and 51% severe fatigue. CONCLUSION: COVID-19 ICU survivors had a higher prevalence for microbleeds but not for cognitive dysfunction compared to general ward survivors. Self-reported symptoms exceeded cognitive dysfunction. Cognitive complaints, neurological symptoms, and severe fatigue were frequently reported in both groups, fitting the post-COVID-19 syndrome.},\n keywords = {SARS-CoV-2\nbrain damage\ncognitive, affective},\n ISSN = {1468-1331 (Electronic)\n1351-5101 (Linking)},\n DOI = {10.1111/ene.15812},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/37010152},\n year = {2023},\n type = {Journal Article}\n}\n\n","author_short":["Klinkhammer, S.","Horn, J.","Duits, A. A.","Visser-Meily, J. M. A.","Verwijk, E.","Slooter, A. J. C.","Postma, A. A.","van Heugten, C. M.","NeNe, S. s. g."],"key":"RN325","id":"RN325","bibbaseid":"klinkhammer-horn-duits-vissermeily-verwijk-slooter-postma-vanheugten-etal-neurologicalandneuropsychologicalsequelaeinintensivecareandgeneralwardcovid19survivors-2023","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/37010152"},"keyword":["SARS-CoV-2 brain damage cognitive","affective"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":["sars-cov-2 brain damage cognitive","affective"],"search_terms":["neurological","neuro","psychological","sequelae","intensive","care","general","ward","covid","survivors","klinkhammer","horn","duits","visser-meily","verwijk","slooter","postma","van heugten","nene"],"title":"Neurological and (neuro)psychological sequelae in intensive care and general ward COVID-19 survivors","year":2023}