@article{kochilas_age-dependent_2014,
	title = {Age-dependent sex effects on outcomes after pediatric cardiac surgery.},
	volume = {3},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/24496232},
	doi = {10.1161/JAHA.113.000608},
	abstract = {BACKGROUND: Sex has been linked to differential outcomes for cardiovascular disease in adults. We examined potential sex differences in outcomes after pediatric cardiac surgery. METHODS AND RESULTS: We retrospectively analyzed data from the Pediatric Cardiac Care Consortium (1982-2007) by using logistic regression to evaluate the effects of sex on 30-day within-hospital mortality after pediatric ({\textless}18 years old) cardiac operations and its interaction with age, risk category, z-score for weight, and surgical year for the whole cohort. Of 76 312 operations, 55\% were in boys. Unadjusted mortality was similar for boys and girls (5.2\% versus 5.0\%, P=0.313), but boys were more likely to have cardiac surgery as a neonate and to have more complex operations. After adjustment, the overall test of any association between postsurgical mortality and sex was significant (P=0.002), but the overall test of any interaction was not (P=0.503). However, a potential age-dependent sex effect on postsurgical mortality was observed among infants subjected to high-risk operations, with girls doing worse during the first 6 months of life. CONCLUSIONS: Patient sex has a significant effect on mortality after pediatric cardiac operations, with an increased risk of death in early infancy for girls after high-risk cardiac operations. This age-dependent relationship supports a sex-related biological effect on postoperative cardiovascular stress.},
	language = {eng},
	number = {1},
	journal = {J Am Heart Assoc},
	author = {Kochilas, LK and Vinocur, JM and Menk, JS},
	month = feb,
	year = {2014},
	keywords = {Treatment Outcome},
	pages = {e000608}
}

{"_id":"cod5x6oSsegrLwtf4","bibbaseid":"kochilas-vinocur-menk-agedependentsexeffectsonoutcomesafterpediatriccardiacsurgery-2014","downloads":0,"creationDate":"2019-02-06T19:19:41.827Z","title":"Age-dependent sex effects on outcomes after pediatric cardiac surgery.","author_short":["Kochilas, L.","Vinocur, J.","Menk, J."],"year":2014,"bibtype":"article","biburl":"https://api.zotero.org/users/5494130/collections/TR8UM4WJ/items?key=bPKCKbQJ3ej3KoeUhSSlR8nj&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Age-dependent sex effects on outcomes after pediatric cardiac surgery.","volume":"3","url":"https://www.ncbi.nlm.nih.gov/pubmed/24496232","doi":"10.1161/JAHA.113.000608","abstract":"BACKGROUND: Sex has been linked to differential outcomes for cardiovascular disease in adults. We examined potential sex differences in outcomes after pediatric cardiac surgery. METHODS AND RESULTS: We retrospectively analyzed data from the Pediatric Cardiac Care Consortium (1982-2007) by using logistic regression to evaluate the effects of sex on 30-day within-hospital mortality after pediatric (\\textless18 years old) cardiac operations and its interaction with age, risk category, z-score for weight, and surgical year for the whole cohort. Of 76 312 operations, 55% were in boys. Unadjusted mortality was similar for boys and girls (5.2% versus 5.0%, P=0.313), but boys were more likely to have cardiac surgery as a neonate and to have more complex operations. After adjustment, the overall test of any association between postsurgical mortality and sex was significant (P=0.002), but the overall test of any interaction was not (P=0.503). However, a potential age-dependent sex effect on postsurgical mortality was observed among infants subjected to high-risk operations, with girls doing worse during the first 6 months of life. CONCLUSIONS: Patient sex has a significant effect on mortality after pediatric cardiac operations, with an increased risk of death in early infancy for girls after high-risk cardiac operations. This age-dependent relationship supports a sex-related biological effect on postoperative cardiovascular stress.","language":"eng","number":"1","journal":"J Am Heart Assoc","author":[{"propositions":[],"lastnames":["Kochilas"],"firstnames":["LK"],"suffixes":[]},{"propositions":[],"lastnames":["Vinocur"],"firstnames":["JM"],"suffixes":[]},{"propositions":[],"lastnames":["Menk"],"firstnames":["JS"],"suffixes":[]}],"month":"February","year":"2014","keywords":"Treatment Outcome","pages":"e000608","bibtex":"@article{kochilas_age-dependent_2014,\n\ttitle = {Age-dependent sex effects on outcomes after pediatric cardiac surgery.},\n\tvolume = {3},\n\turl = {https://www.ncbi.nlm.nih.gov/pubmed/24496232},\n\tdoi = {10.1161/JAHA.113.000608},\n\tabstract = {BACKGROUND: Sex has been linked to differential outcomes for cardiovascular disease in adults. We examined potential sex differences in outcomes after pediatric cardiac surgery. METHODS AND RESULTS: We retrospectively analyzed data from the Pediatric Cardiac Care Consortium (1982-2007) by using logistic regression to evaluate the effects of sex on 30-day within-hospital mortality after pediatric ({\\textless}18 years old) cardiac operations and its interaction with age, risk category, z-score for weight, and surgical year for the whole cohort. Of 76 312 operations, 55\\% were in boys. Unadjusted mortality was similar for boys and girls (5.2\\% versus 5.0\\%, P=0.313), but boys were more likely to have cardiac surgery as a neonate and to have more complex operations. After adjustment, the overall test of any association between postsurgical mortality and sex was significant (P=0.002), but the overall test of any interaction was not (P=0.503). However, a potential age-dependent sex effect on postsurgical mortality was observed among infants subjected to high-risk operations, with girls doing worse during the first 6 months of life. CONCLUSIONS: Patient sex has a significant effect on mortality after pediatric cardiac operations, with an increased risk of death in early infancy for girls after high-risk cardiac operations. This age-dependent relationship supports a sex-related biological effect on postoperative cardiovascular stress.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {J Am Heart Assoc},\n\tauthor = {Kochilas, LK and Vinocur, JM and Menk, JS},\n\tmonth = feb,\n\tyear = {2014},\n\tkeywords = {Treatment Outcome},\n\tpages = {e000608}\n}\n\n","author_short":["Kochilas, L.","Vinocur, J.","Menk, J."],"key":"kochilas_age-dependent_2014","id":"kochilas_age-dependent_2014","bibbaseid":"kochilas-vinocur-menk-agedependentsexeffectsonoutcomesafterpediatriccardiacsurgery-2014","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/24496232"},"keyword":["Treatment Outcome"],"downloads":0,"html":""},"search_terms":["age","dependent","sex","effects","outcomes","pediatric","cardiac","surgery","kochilas","vinocur","menk"],"keywords":["treatment outcome"],"authorIDs":[],"dataSources":["D3kJ3SDyHJDJHj4gQ"]}