Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Koenig, C. M, Lango, J., Pessah, I. N, & Berman, R. F Neurotoxicology and teratology, 34(6):571--80.
Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. [link]Paper  doi  abstract   bibtex   
Polybrominated diphenyl ethers (PBDEs) are flame retardants used worldwide in a variety of commercial goods, and are now widely found in both environmental and biological samples. BDE-47 is one of the most pervasive of these PBDE congeners and therefore is of particular concern. In this study C57BL/6J mice were exposed perinatally to 0.03, 0.1 or 1mg/kg/day of BDE-47, a dose range chosen to encompass human exposure levels. Tissue levels of BDE-47 were measured in the blood, brain, fat and milk of dams and in whole fetal homogenate and blood and brain of pups on gestational day (GD) 15, and postnatal days (PNDs) 1, 10 and 21. From GD 15 to PND 1 levels of BDE-47 increased within dam tissues and then decreased from PNDs 1 to 21. Over the period of lactation levels in dam milk were comparatively high when compared to both brain and blood for all dose groups. Measurable levels of BDE-47 were found in the fetus on GD 15 confirming gestational exposure. From PNDs 1 to 21, levels of BDE-47 in pup tissue increased over the period of lactation due to the transfer of BDE-47 through milk. Behavioral tests of fine motor function and learning and memory were carried out between postnatal weeks 5-17 in order to evaluate the neurobehavioral toxicity of BDE-47. Behavioral deficits were only seen in the Barnes spatial maze where mice in the three exposure groups had longer latencies and traveled longer distances to find the escape hole when compared to vehicle control mice. These results support the conclusions that perinatal exposure to BDE-47 can have neurodevelopmental consequences, and that lactational exposure represents a significant exposure risk during development.
@article{koenig_maternal_nodate,
	title = {Maternal transfer of {BDE}-47 to offspring and neurobehavioral development in {C}57BL/6J mice.},
	volume = {34},
	issn = {1872-9738},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23022914},
	doi = {10.1016/j.ntt.2012.09.005},
	abstract = {Polybrominated diphenyl ethers (PBDEs) are flame retardants used worldwide in a variety of commercial goods, and are now widely found in both environmental and biological samples. BDE-47 is one of the most pervasive of these PBDE congeners and therefore is of particular concern. In this study C57BL/6J mice were exposed perinatally to 0.03, 0.1 or 1mg/kg/day of BDE-47, a dose range chosen to encompass human exposure levels. Tissue levels of BDE-47 were measured in the blood, brain, fat and milk of dams and in whole fetal homogenate and blood and brain of pups on gestational day (GD) 15, and postnatal days (PNDs) 1, 10 and 21. From GD 15 to PND 1 levels of BDE-47 increased within dam tissues and then decreased from PNDs 1 to 21. Over the period of lactation levels in dam milk were comparatively high when compared to both brain and blood for all dose groups. Measurable levels of BDE-47 were found in the fetus on GD 15 confirming gestational exposure. From PNDs 1 to 21, levels of BDE-47 in pup tissue increased over the period of lactation due to the transfer of BDE-47 through milk. Behavioral tests of fine motor function and learning and memory were carried out between postnatal weeks 5-17 in order to evaluate the neurobehavioral toxicity of BDE-47. Behavioral deficits were only seen in the Barnes spatial maze where mice in the three exposure groups had longer latencies and traveled longer distances to find the escape hole when compared to vehicle control mice. These results support the conclusions that perinatal exposure to BDE-47 can have neurodevelopmental consequences, and that lactational exposure represents a significant exposure risk during development.},
	number = {6},
	journal = {Neurotoxicology and teratology},
	author = {Koenig, Claire M and Lango, Jozsef and Pessah, Isaac N and Berman, Robert F},
	pmid = {23022914},
	keywords = {Animal, Animal: drug effects, Animals, Behavior, Environmental Pollutants, Environmental Pollutants: pharmacokinetics, Environmental Pollutants: toxicity, Female, Flame retardants, Inbred C57BL, Male, Maternal-Fetal Exchange, Mice, Milk, Milk: metabolism, Motor Activity, Motor Activity: drug effects, Nervous System, Nervous System: drug effects, Nervous System: embryology, Nervous System: growth \& development, Polybrominated Biphenyls, Polybrominated Biphenyls: pharmacokinetics, Polybrominated Biphenyls: toxicity, Pregnancy, Prenatal Exposure Delayed Effects, Prenatal Exposure Delayed Effects: chemically indu, Prenatal Exposure Delayed Effects: metabolism, Tissue Distribution},
	pages = {571--80}
}

Downloads: 0