Ion permeation in K+ channels occurs by direct Coulomb knock-on. Kopfer, D. A., Song, C., Gruene, T., Sheldrick, G. M., Zachariae, U., & de Groot, B. L. Science, 346(6207):352–355, October, 2014. arXiv: 1011.1669v3 ISBN: 1095-9203 (Electronic)\r0036-8075 (Linking)![Ion permeation in K+ channels occurs by direct Coulomb knock-on [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Potassium channels selectively conduct K(+) ions across cellular membranes with extraordinary efficiency. Their selectivity filter exhibits four binding sites with approximately equal electron density in crystal structures with high K(+) concentrations, previously thought to reflect a superposition of alternating ion- and water-occupied states. Consequently, cotranslocation of ions with water has become a widely accepted ion conduction mechanism for potassium channels. By analyzing more than 1300 permeation events from molecular dynamics simulations at physiological voltages, we observed instead that permeation occurs via ion-ion contacts between neighboring K(+) ions. Coulomb repulsion between adjacent ions is found to be the key to high-efficiency K(+) conduction. Crystallographic data are consistent with directly neighboring K(+) ions in the selectivity filter, and our model offers an intuitive explanation for the high throughput rates of K(+) channels.
@article{Kopfer2014,
title = {Ion permeation in {K}+ channels occurs by direct {Coulomb} knock-on},
volume = {346},
issn = {0036-8075},
url = {http://www.sciencemag.org/cgi/doi/10.1126/science.1254840},
doi = {10.1126/science.1254840},
abstract = {Potassium channels selectively conduct K(+) ions across cellular membranes with extraordinary efficiency. Their selectivity filter exhibits four binding sites with approximately equal electron density in crystal structures with high K(+) concentrations, previously thought to reflect a superposition of alternating ion- and water-occupied states. Consequently, cotranslocation of ions with water has become a widely accepted ion conduction mechanism for potassium channels. By analyzing more than 1300 permeation events from molecular dynamics simulations at physiological voltages, we observed instead that permeation occurs via ion-ion contacts between neighboring K(+) ions. Coulomb repulsion between adjacent ions is found to be the key to high-efficiency K(+) conduction. Crystallographic data are consistent with directly neighboring K(+) ions in the selectivity filter, and our model offers an intuitive explanation for the high throughput rates of K(+) channels.},
number = {6207},
urldate = {2014-10-16},
journal = {Science},
author = {Kopfer, D. A. and Song, C. and Gruene, T. and Sheldrick, G. M. and Zachariae, U. and de Groot, B. L.},
month = oct,
year = {2014},
pmid = {25324389},
note = {arXiv: 1011.1669v3
ISBN: 1095-9203 (Electronic){\textbackslash}r0036-8075 (Linking)},
pages = {352--355},
}
Downloads: 0
{"_id":"kdM7NBSB4mFyiBg9o","bibbaseid":"kopfer-song-gruene-sheldrick-zachariae-degroot-ionpermeationinkchannelsoccursbydirectcoulombknockon-2014","author_short":["Kopfer, D. A.","Song, C.","Gruene, T.","Sheldrick, G. M.","Zachariae, U.","de Groot, B. L."],"bibdata":{"bibtype":"article","type":"article","title":"Ion permeation in K+ channels occurs by direct Coulomb knock-on","volume":"346","issn":"0036-8075","url":"http://www.sciencemag.org/cgi/doi/10.1126/science.1254840","doi":"10.1126/science.1254840","abstract":"Potassium channels selectively conduct K(+) ions across cellular membranes with extraordinary efficiency. Their selectivity filter exhibits four binding sites with approximately equal electron density in crystal structures with high K(+) concentrations, previously thought to reflect a superposition of alternating ion- and water-occupied states. Consequently, cotranslocation of ions with water has become a widely accepted ion conduction mechanism for potassium channels. By analyzing more than 1300 permeation events from molecular dynamics simulations at physiological voltages, we observed instead that permeation occurs via ion-ion contacts between neighboring K(+) ions. Coulomb repulsion between adjacent ions is found to be the key to high-efficiency K(+) conduction. Crystallographic data are consistent with directly neighboring K(+) ions in the selectivity filter, and our model offers an intuitive explanation for the high throughput rates of K(+) channels.","number":"6207","urldate":"2014-10-16","journal":"Science","author":[{"propositions":[],"lastnames":["Kopfer"],"firstnames":["D.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Song"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Gruene"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Sheldrick"],"firstnames":["G.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Zachariae"],"firstnames":["U."],"suffixes":[]},{"propositions":["de"],"lastnames":["Groot"],"firstnames":["B.","L."],"suffixes":[]}],"month":"October","year":"2014","pmid":"25324389","note":"arXiv: 1011.1669v3 ISBN: 1095-9203 (Electronic)\\r0036-8075 (Linking)","pages":"352–355","bibtex":"@article{Kopfer2014,\n\ttitle = {Ion permeation in {K}+ channels occurs by direct {Coulomb} knock-on},\n\tvolume = {346},\n\tissn = {0036-8075},\n\turl = {http://www.sciencemag.org/cgi/doi/10.1126/science.1254840},\n\tdoi = {10.1126/science.1254840},\n\tabstract = {Potassium channels selectively conduct K(+) ions across cellular membranes with extraordinary efficiency. Their selectivity filter exhibits four binding sites with approximately equal electron density in crystal structures with high K(+) concentrations, previously thought to reflect a superposition of alternating ion- and water-occupied states. Consequently, cotranslocation of ions with water has become a widely accepted ion conduction mechanism for potassium channels. By analyzing more than 1300 permeation events from molecular dynamics simulations at physiological voltages, we observed instead that permeation occurs via ion-ion contacts between neighboring K(+) ions. Coulomb repulsion between adjacent ions is found to be the key to high-efficiency K(+) conduction. Crystallographic data are consistent with directly neighboring K(+) ions in the selectivity filter, and our model offers an intuitive explanation for the high throughput rates of K(+) channels.},\n\tnumber = {6207},\n\turldate = {2014-10-16},\n\tjournal = {Science},\n\tauthor = {Kopfer, D. A. and Song, C. and Gruene, T. and Sheldrick, G. M. and Zachariae, U. and de Groot, B. L.},\n\tmonth = oct,\n\tyear = {2014},\n\tpmid = {25324389},\n\tnote = {arXiv: 1011.1669v3\nISBN: 1095-9203 (Electronic){\\textbackslash}r0036-8075 (Linking)},\n\tpages = {352--355},\n}\n\n","author_short":["Kopfer, D. A.","Song, C.","Gruene, T.","Sheldrick, G. M.","Zachariae, U.","de Groot, B. L."],"key":"Kopfer2014","id":"Kopfer2014","bibbaseid":"kopfer-song-gruene-sheldrick-zachariae-degroot-ionpermeationinkchannelsoccursbydirectcoulombknockon-2014","role":"author","urls":{"Paper":"http://www.sciencemag.org/cgi/doi/10.1126/science.1254840"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5315842/items?key=aJYPXNdgkztwX5veTDCe51qx&format=bibtex&limit=100","dataSources":["eJ9d2SWWJDCrSLaKb"],"keywords":[],"search_terms":["ion","permeation","channels","occurs","direct","coulomb","knock","kopfer","song","gruene","sheldrick","zachariae","de groot"],"title":"Ion permeation in K+ channels occurs by direct Coulomb knock-on","year":2014}