Rate of decline in renal function in Indo-Asians and Whites with diabetic nephropathy. Koppiker, N., Feehally, J., Raymond, N., Abrams, K. R., & Burden, A. C. Diabetic Medicine: A Journal of the British Diabetic Association, 15(1):60–65, January, 1998. doi abstract bibtex The incidence of end-stage renal failure (ESRF) is higher in the Indo-Asian ethnic group as compared to the White. To investigate whether this might be associated with faster rates of progression to ESRF in Indo-Asian diabetic patients, we studied a total of 39 Type 2 diabetic patients, using the Department of Nephrology database showing serial serum creatinine measurements from the time of first referral to the clinic until they reached a level of \textgreater500 micromol l(-1) or ESRF requiring renal replacement therapy (RRT), either dialysis or renal transplantation. They were grouped into Indo-Asian (n = 24) and White (n = 15). The rate of progression of those who developed ESRF, calculated as the slope of log serum creatinine against time, was not significantly different between the Indo-Asian and White patients, p = 0.73. We conclude that the higher incidence of ESRF in the Indo-Asian Type 2 diabetic patient with nephropathy is therefore not due to a faster rate of deterioration in renal function.
@article{koppiker_rate_1998-1,
title = {Rate of decline in renal function in {Indo}-{Asians} and {Whites} with diabetic nephropathy},
volume = {15},
issn = {0742-3071},
doi = {10.1002/(SICI)1096-9136(199801)15:1<60::AID-DIA525>3.0.CO;2-R},
abstract = {The incidence of end-stage renal failure (ESRF) is higher in the Indo-Asian ethnic group as compared to the White. To investigate whether this might be associated with faster rates of progression to ESRF in Indo-Asian diabetic patients, we studied a total of 39 Type 2 diabetic patients, using the Department of Nephrology database showing serial serum creatinine measurements from the time of first referral to the clinic until they reached a level of {\textbackslash}textgreater500 micromol l(-1) or ESRF requiring renal replacement therapy (RRT), either dialysis or renal transplantation. They were grouped into Indo-Asian (n = 24) and White (n = 15). The rate of progression of those who developed ESRF, calculated as the slope of log serum creatinine against time, was not significantly different between the Indo-Asian and White patients, p = 0.73. We conclude that the higher incidence of ESRF in the Indo-Asian Type 2 diabetic patient with nephropathy is therefore not due to a faster rate of deterioration in renal function.},
language = {eng},
number = {1},
journal = {Diabetic Medicine: A Journal of the British Diabetic Association},
author = {Koppiker, N. and Feehally, J. and Raymond, N. and Abrams, K. R. and Burden, A. C.},
month = jan,
year = {1998},
pmid = {9472865},
keywords = {Adult, Aged, Asia, Chronic, Diabetic Nephropathies, Disease Progression, European Continental Ancestry Group, Female, Humans, Incidence, Kidney Failure, Kidney Function Tests, Male, Middle Aged, United Kingdom},
pages = {60--65},
}
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To investigate whether this might be associated with faster rates of progression to ESRF in Indo-Asian diabetic patients, we studied a total of 39 Type 2 diabetic patients, using the Department of Nephrology database showing serial serum creatinine measurements from the time of first referral to the clinic until they reached a level of \\textgreater500 micromol l(-1) or ESRF requiring renal replacement therapy (RRT), either dialysis or renal transplantation. They were grouped into Indo-Asian (n = 24) and White (n = 15). The rate of progression of those who developed ESRF, calculated as the slope of log serum creatinine against time, was not significantly different between the Indo-Asian and White patients, p = 0.73. 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