Multielectrode Transcranial Electrical Stimulation of the Left and Right Prefrontal Cortices Differentially Impacts Verbal Working Memory Neural Circuitry. Koshy, S. M., Wiesman, A. I., Spooner, R. K., Embury, C., Rezich, M. T., Heinrichs-Graham, E., & Wilson, T. W. Cerebral cortex (New York, N.Y. : 1991), 30(4):2389–2400, April, 2020. Place: United Statesdoi abstract bibtex Recent studies have examined the effects of conventional transcranial direct current stimulation (tDCS) on working memory (WM) performance, but this method has relatively low spatial precision and generally involves a reference electrode that complicates interpretation. Herein, we report a repeated-measures crossover study of 25 healthy adults who underwent multielectrode tDCS of the left dorsolateral prefrontal cortex (DLPFC), right DLPFC, or sham in 3 separate visits. Shortly after each stimulation session, participants performed a verbal WM (VWM) task during magnetoencephalography, and the resulting data were examined in the time-frequency domain and imaged using a beamformer. We found that after left DLPFC stimulation, participants exhibited stronger responses across a network of left-lateralized cortical areas, including the supramarginal gyrus, prefrontal cortex, inferior frontal gyrus, and cuneus, as well as the right hemispheric homologues of these regions. Importantly, these effects were specific to the alpha-band, which has been previously implicated in VWM processing. Although stimulation condition did not significantly affect performance, stepwise regression revealed a relationship between reaction time and response amplitude in the left precuneus and supramarginal gyrus. These findings suggest that multielectrode tDCS targeting the left DLPFC affects the neural dynamics underlying offline VWM processing, including utilization of a more extensive bilateral cortical network.
@article{koshy_multielectrode_2020,
title = {Multielectrode {Transcranial} {Electrical} {Stimulation} of the {Left} and {Right} {Prefrontal} {Cortices} {Differentially} {Impacts} {Verbal} {Working} {Memory} {Neural} {Circuitry}.},
volume = {30},
copyright = {© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.},
issn = {1460-2199 1047-3211},
doi = {10.1093/cercor/bhz246},
abstract = {Recent studies have examined the effects of conventional transcranial direct current stimulation (tDCS) on working memory (WM) performance, but this method has relatively low spatial precision and generally involves a reference electrode that complicates interpretation. Herein, we report a repeated-measures crossover study of 25 healthy adults who underwent multielectrode tDCS of the left dorsolateral prefrontal cortex (DLPFC), right DLPFC, or sham in 3 separate visits. Shortly after each stimulation session, participants performed a verbal WM (VWM) task during magnetoencephalography, and the resulting data were examined in the time-frequency domain and imaged using a beamformer. We found that after left DLPFC stimulation, participants exhibited stronger responses across a network of left-lateralized cortical areas, including the supramarginal gyrus, prefrontal cortex, inferior frontal gyrus, and cuneus, as well as the right hemispheric homologues of these regions. Importantly, these effects were specific to the alpha-band, which has been previously implicated in VWM processing. Although stimulation condition did not significantly affect performance, stepwise regression revealed a relationship between reaction time and response amplitude in the left precuneus and supramarginal gyrus. These findings suggest that multielectrode tDCS targeting the left DLPFC affects the neural dynamics underlying offline VWM processing, including utilization of a more extensive bilateral cortical network.},
language = {eng},
number = {4},
journal = {Cerebral cortex (New York, N.Y. : 1991)},
author = {Koshy, Sam M. and Wiesman, Alex I. and Spooner, Rachel K. and Embury, Christine and Rezich, Michael T. and Heinrichs-Graham, Elizabeth and Wilson, Tony W.},
month = apr,
year = {2020},
pmid = {31799616},
pmcid = {PMC7175008},
note = {Place: United States},
keywords = {Adult, Cross-Over Studies, Electrodes, Female, Humans, Male, Memory, Short-Term/*physiology, Nerve Net/diagnostic imaging/*physiology, Prefrontal Cortex/diagnostic imaging/*physiology, Random Allocation, Reaction Time/*physiology, Single-Blind Method, Transcranial Direct Current Stimulation/instrumentation/*methods, Verbal Learning/*physiology, Young Adult, magnetoencephalography, neurostimulation, transcranial direct current stimulation, working memory},
pages = {2389--2400},
}
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For permissions, please e-mail: journals.permissions@oup.com.","issn":"1460-2199 1047-3211","doi":"10.1093/cercor/bhz246","abstract":"Recent studies have examined the effects of conventional transcranial direct current stimulation (tDCS) on working memory (WM) performance, but this method has relatively low spatial precision and generally involves a reference electrode that complicates interpretation. Herein, we report a repeated-measures crossover study of 25 healthy adults who underwent multielectrode tDCS of the left dorsolateral prefrontal cortex (DLPFC), right DLPFC, or sham in 3 separate visits. Shortly after each stimulation session, participants performed a verbal WM (VWM) task during magnetoencephalography, and the resulting data were examined in the time-frequency domain and imaged using a beamformer. We found that after left DLPFC stimulation, participants exhibited stronger responses across a network of left-lateralized cortical areas, including the supramarginal gyrus, prefrontal cortex, inferior frontal gyrus, and cuneus, as well as the right hemispheric homologues of these regions. Importantly, these effects were specific to the alpha-band, which has been previously implicated in VWM processing. Although stimulation condition did not significantly affect performance, stepwise regression revealed a relationship between reaction time and response amplitude in the left precuneus and supramarginal gyrus. 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