Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein E4 genotype. Kota, L. N., Bharath, S., Purushottam, M., Paul, P., Sivakumar, P. T., Varghese, M., & Jain, S. Asian Journal of Psychiatry, 12:58–62, December, 2014. doi abstract bibtex Apolipoprotein E4 gene is associated with increased risk of dementia with comorbid diabetes mellitus. Both dementia and diabetes mellitus type 2 are independently associated with telomere shortening. We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) and cognitively normal control groups (n=55) with and without comorbid diabetes mellitus type 2. Relative telomere length was highest in the control group (Q2=0.91) followed by dementia (Q2=0.48) and dementia with comorbid diabetes mellitus type 2 (Q2=0.39). Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P\textgreater0.05). The findings suggest that relative telomere length is unrelated to apolipoprotein E4 genotype in dementia and cognitive normal subjects with or without comorbid diabetes mellitus type 2.
@article{kota_reduced_2014,
title = {Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein {E4} genotype},
volume = {12},
issn = {1876-2026},
doi = {10.1016/j.ajp.2014.06.012},
abstract = {Apolipoprotein E4 gene is associated with increased risk of dementia with comorbid diabetes mellitus. Both dementia and diabetes mellitus type 2 are independently associated with telomere shortening. We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) and cognitively normal control groups (n=55) with and without comorbid diabetes mellitus type 2. Relative telomere length was highest in the control group (Q2=0.91) followed by dementia (Q2=0.48) and dementia with comorbid diabetes mellitus type 2 (Q2=0.39). Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P{\textgreater}0.05). The findings suggest that relative telomere length is unrelated to apolipoprotein E4 genotype in dementia and cognitive normal subjects with or without comorbid diabetes mellitus type 2.},
language = {eng},
journal = {Asian Journal of Psychiatry},
author = {Kota, Lakshmi Narayanan and Bharath, Srikala and Purushottam, Meera and Paul, Pradip and Sivakumar, Palanimuthu Thangaraju and Varghese, Mathew and Jain, Sanjeev},
month = dec,
year = {2014},
pmid = {25440562},
keywords = {Aged, Alleles, Apolipoprotein E4, Apolipoprotein E4/*genetics, Dementia, Dementia with diabetes, Dementia/*genetics, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 2/*genetics, Female, Gene Frequency, Genetic Association Studies, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Telomere, Telomere Shortening, Telomere Shortening/*genetics, Telomere/*genetics},
pages = {58--62},
}
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Relative telomere length was highest in the control group (Q2=0.91) followed by dementia (Q2=0.48) and dementia with comorbid diabetes mellitus type 2 (Q2=0.39). Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P\\textgreater0.05). The findings suggest that relative telomere length is unrelated to apolipoprotein E4 genotype in dementia and cognitive normal subjects with or without comorbid diabetes mellitus type 2.","language":"eng","journal":"Asian Journal of Psychiatry","author":[{"propositions":[],"lastnames":["Kota"],"firstnames":["Lakshmi","Narayanan"],"suffixes":[]},{"propositions":[],"lastnames":["Bharath"],"firstnames":["Srikala"],"suffixes":[]},{"propositions":[],"lastnames":["Purushottam"],"firstnames":["Meera"],"suffixes":[]},{"propositions":[],"lastnames":["Paul"],"firstnames":["Pradip"],"suffixes":[]},{"propositions":[],"lastnames":["Sivakumar"],"firstnames":["Palanimuthu","Thangaraju"],"suffixes":[]},{"propositions":[],"lastnames":["Varghese"],"firstnames":["Mathew"],"suffixes":[]},{"propositions":[],"lastnames":["Jain"],"firstnames":["Sanjeev"],"suffixes":[]}],"month":"December","year":"2014","pmid":"25440562","keywords":"Aged, Alleles, Apolipoprotein E4, Apolipoprotein E4/*genetics, Dementia, Dementia with diabetes, Dementia/*genetics, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 2/*genetics, Female, Gene Frequency, Genetic Association Studies, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Telomere, Telomere Shortening, Telomere Shortening/*genetics, Telomere/*genetics","pages":"58–62","bibtex":"@article{kota_reduced_2014,\n\ttitle = {Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of apolipoprotein {E4} genotype},\n\tvolume = {12},\n\tissn = {1876-2026},\n\tdoi = {10.1016/j.ajp.2014.06.012},\n\tabstract = {Apolipoprotein E4 gene is associated with increased risk of dementia with comorbid diabetes mellitus. Both dementia and diabetes mellitus type 2 are independently associated with telomere shortening. We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) and cognitively normal control groups (n=55) with and without comorbid diabetes mellitus type 2. Relative telomere length was highest in the control group (Q2=0.91) followed by dementia (Q2=0.48) and dementia with comorbid diabetes mellitus type 2 (Q2=0.39). Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P{\\textgreater}0.05). 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