Efficacy and tolerability of felodipine based antihypertensive therapy in hospitalized patients with hypertension. Kotovskaia, I., V.; Bagmanova, N., K.; Mil'to, A., S.; Riabova, A., V.; Plavunov, N., F.; and Kobalava, Z., D. Kardiologiia, 44(3):47-51, 2004.
Efficacy and tolerability of felodipine based antihypertensive therapy in hospitalized patients with hypertension [link]Website  abstract   bibtex   
AIM: To compare efficacy and tolerability of felodipine based antihypertensive therapy with those of standard hospital treatment of hypertension. MATERIAL: Inhospital patients were randomized 1:2 to standard antihypertensive therapy or to therapy which included felodipine (n=50 and 100, 36 and 35% men, mean age 66.0+/-8.4 and 64.3+/-8.1 years, initial blood pressure 162.4+/-9.3/99.3+/-6.4 and 163.2+/-10.3/98.2+/-6.5 mm Hg, respectively). Felodipine was used: (1) as first drug with subsequent addition of other drugs as required; (2) after cessation of previously ineffective therapy; (3) in cases of intolerance to previous therapy, (4) as supplementation to previously insufficiently effective therapy. Results. At discharge in felodipine group 6, 25, 29 and 40% of patients received mono- (felodipine 10 mg/day), 2, 3 and 4 component therapy, respectively. In standard treatment group all patients received combination therapy with 3 (48%) or 4 (52%) drugs. Felodipine group compared with group of standard therapy was characterized by less frequent correction of antihypertensive therapy (0.8+/-0.6 and 2.2+/-0.9, p<0.05), smaller number of drugs used (3.03+/-0.95 and 3.52+/-0.5, p<0.01), more frequently achievement of target blood pressure level (88 and 64%, p=0.0075), less pronounced difference between morning and evening self-measured blood pressure. CONCLUSION: The use of felodipine in hospitalized patients with hypertension allowed achieving target blood pressure with fewer drugs. Felodipine was safe and well tolerated.
@article{
 title = {Efficacy and tolerability of felodipine based antihypertensive therapy in hospitalized patients with hypertension},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {Aged,Antihypertensive Agents,Calcium Channel Blockers,Combination,Drug Therapy,Felodipine,Female,Humans,Hypertension,Inpatients,Male,Middle Aged,Safety,Time Factors,Treatment Outcome},
 pages = {47-51},
 volume = {44},
 websites = {https://elibrary.ru/item.asp?id=17063460,http://www.ncbi.nlm.nih.gov/pubmed/15489847},
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 abstract = {AIM: To compare efficacy and tolerability of felodipine based antihypertensive therapy with those of standard hospital treatment of hypertension. MATERIAL: Inhospital patients were randomized 1:2 to standard antihypertensive therapy or to therapy which included felodipine (n=50 and 100, 36 and 35% men, mean age 66.0+/-8.4 and 64.3+/-8.1 years, initial blood pressure 162.4+/-9.3/99.3+/-6.4 and 163.2+/-10.3/98.2+/-6.5 mm Hg, respectively). Felodipine was used: (1) as first drug with subsequent addition of other drugs as required; (2) after cessation of previously ineffective therapy; (3) in cases of intolerance to previous therapy, (4) as supplementation to previously insufficiently effective therapy. Results. At discharge in felodipine group 6, 25, 29 and 40% of patients received mono- (felodipine 10 mg/day), 2, 3 and 4 component therapy, respectively. In standard treatment group all patients received combination therapy with 3 (48%) or 4 (52%) drugs. Felodipine group compared with group of standard therapy was characterized by less frequent correction of antihypertensive therapy (0.8+/-0.6 and 2.2+/-0.9, p<0.05), smaller number of drugs used (3.03+/-0.95 and 3.52+/-0.5, p<0.01), more frequently achievement of target blood pressure level (88 and 64%, p=0.0075), less pronounced difference between morning and evening self-measured blood pressure. CONCLUSION: The use of felodipine in hospitalized patients with hypertension allowed achieving target blood pressure with fewer drugs. Felodipine was safe and well tolerated.},
 bibtype = {article},
 author = {Kotovskaia, Iu V. and Bagmanova, N. Kh and Mil'to, A. S. and Riabova, A. V. and Plavunov, N. F. and Kobalava, Zh D.},
 journal = {Kardiologiia},
 number = {3}
}
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