@article{krasovec_d-serine_2022,
	title = {d-{Serine} controls epidermal vesicle release via {NMDA} receptor, allowing tissue migration during the metamorphosis of the chordate \textit{{Ciona}}},
	volume = {8},
	issn = {2375-2548},
	shorttitle = {{\textless}span style="font-variant},
	url = {https://www.science.org/doi/10.1126/sciadv.abn3264},
	doi = {10.1126/sciadv.abn3264},
	abstract = {d
              -Serine, a free amino acid synthesized by serine racemase, is a coagonist of
              N
              -methyl-
              d
              -aspartate–type glutamate receptor (NMDAR).
              d
              -Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of
              d
              -serine in mammalian peripheral tissues such as skin have also been described. However,
              d
              -serine’s functions in nonmammals are unclear. Here, we characterized
              d
              -serine–dependent vesicle release from the epidermis during metamorphosis of the tunicate
              Ciona
              .
              d
              -Serine leads to the formation of a pocket that facilitates the arrival of migrating tissue during tail regression. NMDAR is the receptor of
              d
              -serine in the formation of the epidermal pocket. The epidermal pocket is formed by the release of epidermal vesicles’ content mediated by
              d
              -serine/NMDAR. This mechanism is similar to observations of keratinocyte vesicle exocytosis in mammalian skin. Our findings provide a better understanding of the maintenance of epidermal homeostasis in animals and contribute to further evolutionary perspectives of
              d
              -amino acid function among metazoans.
            
          , 
            
              Tunicates and mammals have a shared mechanism in the regulation of epidermal vesicle release mediated by
              d
              -serine and NMDAR.},
	language = {en},
	number = {10},
	urldate = {2022-03-14},
	journal = {Science Advances},
	author = {Krasovec, Gabriel and Hozumi, Akiko and Yoshida, Tomoyuki and Obita, Takayuki and Hamada, Mayuko and Shiraishi, Akira and Satake, Honoo and Horie, Takeo and Mori, Hisashi and Sasakura, Yasunori},
	month = mar,
	year = {2022},
	pages = {eabn3264},
}

{"_id":"aChP9im5TpAEAPM9s","bibbaseid":"krasovec-hozumi-yoshida-obita-hamada-shiraishi-satake-horie-etal-dserinecontrolsepidermalvesiclereleasevianmdareceptorallowingtissuemigrationduringthemetamorphosisofthechordateicionai-2022","author_short":["Krasovec, G.","Hozumi, A.","Yoshida, T.","Obita, T.","Hamada, M.","Shiraishi, A.","Satake, H.","Horie, T.","Mori, H.","Sasakura, Y."],"bibdata":{"bibtype":"article","type":"article","title":"d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate <i>Ciona</i>","volume":"8","issn":"2375-2548","shorttitle":"\\textlessspan style=\"font-variant","url":"https://www.science.org/doi/10.1126/sciadv.abn3264","doi":"10.1126/sciadv.abn3264","abstract":"d -Serine, a free amino acid synthesized by serine racemase, is a coagonist of N -methyl- d -aspartate–type glutamate receptor (NMDAR). d -Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of d -serine in mammalian peripheral tissues such as skin have also been described. However, d -serine’s functions in nonmammals are unclear. Here, we characterized d -serine–dependent vesicle release from the epidermis during metamorphosis of the tunicate Ciona . d -Serine leads to the formation of a pocket that facilitates the arrival of migrating tissue during tail regression. NMDAR is the receptor of d -serine in the formation of the epidermal pocket. The epidermal pocket is formed by the release of epidermal vesicles’ content mediated by d -serine/NMDAR. This mechanism is similar to observations of keratinocyte vesicle exocytosis in mammalian skin. Our findings provide a better understanding of the maintenance of epidermal homeostasis in animals and contribute to further evolutionary perspectives of d -amino acid function among metazoans. , Tunicates and mammals have a shared mechanism in the regulation of epidermal vesicle release mediated by d -serine and NMDAR.","language":"en","number":"10","urldate":"2022-03-14","journal":"Science Advances","author":[{"propositions":[],"lastnames":["Krasovec"],"firstnames":["Gabriel"],"suffixes":[]},{"propositions":[],"lastnames":["Hozumi"],"firstnames":["Akiko"],"suffixes":[]},{"propositions":[],"lastnames":["Yoshida"],"firstnames":["Tomoyuki"],"suffixes":[]},{"propositions":[],"lastnames":["Obita"],"firstnames":["Takayuki"],"suffixes":[]},{"propositions":[],"lastnames":["Hamada"],"firstnames":["Mayuko"],"suffixes":[]},{"propositions":[],"lastnames":["Shiraishi"],"firstnames":["Akira"],"suffixes":[]},{"propositions":[],"lastnames":["Satake"],"firstnames":["Honoo"],"suffixes":[]},{"propositions":[],"lastnames":["Horie"],"firstnames":["Takeo"],"suffixes":[]},{"propositions":[],"lastnames":["Mori"],"firstnames":["Hisashi"],"suffixes":[]},{"propositions":[],"lastnames":["Sasakura"],"firstnames":["Yasunori"],"suffixes":[]}],"month":"March","year":"2022","pages":"eabn3264","bibtex":"@article{krasovec_d-serine_2022,\n\ttitle = {d-{Serine} controls epidermal vesicle release via {NMDA} receptor, allowing tissue migration during the metamorphosis of the chordate \\textit{{Ciona}}},\n\tvolume = {8},\n\tissn = {2375-2548},\n\tshorttitle = {{\\textless}span style=\"font-variant},\n\turl = {https://www.science.org/doi/10.1126/sciadv.abn3264},\n\tdoi = {10.1126/sciadv.abn3264},\n\tabstract = {d\n -Serine, a free amino acid synthesized by serine racemase, is a coagonist of\n N\n -methyl-\n d\n -aspartate–type glutamate receptor (NMDAR).\n d\n -Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of\n d\n -serine in mammalian peripheral tissues such as skin have also been described. However,\n d\n -serine’s functions in nonmammals are unclear. Here, we characterized\n d\n -serine–dependent vesicle release from the epidermis during metamorphosis of the tunicate\n Ciona\n .\n d\n -Serine leads to the formation of a pocket that facilitates the arrival of migrating tissue during tail regression. NMDAR is the receptor of\n d\n -serine in the formation of the epidermal pocket. The epidermal pocket is formed by the release of epidermal vesicles’ content mediated by\n d\n -serine/NMDAR. This mechanism is similar to observations of keratinocyte vesicle exocytosis in mammalian skin. Our findings provide a better understanding of the maintenance of epidermal homeostasis in animals and contribute to further evolutionary perspectives of\n d\n -amino acid function among metazoans.\n \n , \n \n Tunicates and mammals have a shared mechanism in the regulation of epidermal vesicle release mediated by\n d\n -serine and NMDAR.},\n\tlanguage = {en},\n\tnumber = {10},\n\turldate = {2022-03-14},\n\tjournal = {Science Advances},\n\tauthor = {Krasovec, Gabriel and Hozumi, Akiko and Yoshida, Tomoyuki and Obita, Takayuki and Hamada, Mayuko and Shiraishi, Akira and Satake, Honoo and Horie, Takeo and Mori, Hisashi and Sasakura, Yasunori},\n\tmonth = mar,\n\tyear = {2022},\n\tpages = {eabn3264},\n}\n\n","author_short":["Krasovec, G.","Hozumi, A.","Yoshida, T.","Obita, T.","Hamada, M.","Shiraishi, A.","Satake, H.","Horie, T.","Mori, H.","Sasakura, Y."],"key":"krasovec_d-serine_2022","id":"krasovec_d-serine_2022","bibbaseid":"krasovec-hozumi-yoshida-obita-hamada-shiraishi-satake-horie-etal-dserinecontrolsepidermalvesiclereleasevianmdareceptorallowingtissuemigrationduringthemetamorphosisofthechordateicionai-2022","role":"author","urls":{"Paper":"https://www.science.org/doi/10.1126/sciadv.abn3264"},"metadata":{"authorlinks":{}},"downloads":30},"bibtype":"article","biburl":"https://api.zotero.org/users/3476755/collections/IHG8YRKP/items?key=VpWpxx7vAcI1RFC3pAUNOY4B&format=bibtex&limit=100","dataSources":["eHX34wrqieEKj9Bwc","Lph9J5gJhTNh35cGm"],"keywords":[],"search_terms":["serine","controls","epidermal","vesicle","release","via","nmda","receptor","allowing","tissue","migration","during","metamorphosis","chordate","ciona","krasovec","hozumi","yoshida","obita","hamada","shiraishi","satake","horie","mori","sasakura"],"title":"d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate <i>Ciona</i>","year":2022,"downloads":30}