Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Kraus, V. B., Blanco, F. J., Englund, M., Karsdal, M. A., & Lohmander, L. S. 23(8):1233--1241.
doi  abstract   bibtex   
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of OA Development) and ROAP (Risk of OA Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages - REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools.
@article{kraus_call_2015,
	title = {Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use},
	volume = {23},
	issn = {1522-9653},
	doi = {10.1016/j.joca.2015.03.036},
	abstract = {Osteoarthritis ({OA}) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for {OA} that could serve as building blocks for describing {OA} and defining {OA} phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of {ROAD} (Risk of {OA} Development) and {ROAP} (Risk of {OA} Progression) tools analogous to the {FRAX}™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages - {REDI} (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for {OA} could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools.},
	pages = {1233--1241},
	number = {8},
	journaltitle = {Osteoarthritis and cartilage / {OARS}, Osteoarthritis Research Society},
	shortjournal = {Osteoarthr. Cartil.},
	author = {Kraus, V. B. and Blanco, F. J. and Englund, M. and Karsdal, M. A. and Lohmander, L. S.},
	date = {2015-08},
	pmid = {25865392},
	pmcid = {PMC4516635},
	keywords = {Anatomy, Biomarkers, Clinical Trials as Topic, Criteria, Definition, Disease Progression, Health Promotion, Humans, Osteoarthritis, Osteoporotic Fractures, Patient Outcome Assessment, Physiology, Risk Assessment, Terminology as Topic}
}
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