@ARTICLE{Kriegstein1987-jd,
  title    = "Cellular and synaptic physiology and epileptogenesis of
              developing rat neocortical neurons in vitro",
  author   = "Kriegstein, A R and Suppes, T and Prince, D A",
  abstract = "The cellular and synaptic physiology of developing rat
              neocortical neurons was studied using the in vitro slice method.
              Rats aged 1-28 days were used for analysis. During the first two
              postnatal weeks several sequential changes occur in membrane
              properties and evoked synaptic potentials. Immature neurons had
              higher input resistances, more linear I-V characteristics, longer
              membrane time constants, and slower rising and falling phases of
              action potentials. The developmental increase in rate of rise of
              the action potential suggests an increasing density of
              voltage-dependent Na+-channels are inserted in neuronal membranes
              during postnatal development. The higher input resistance of
              young cells might be due to their small size and differences in
              membrane properties. The long time constant indicates a higher
              specific membrane resistivity of immature neurons. Postsynaptic
              potentials (PSPs) recorded in young neurons were longer in
              latency, longer in duration, and more fragile during repetitive
              activation than their mature counterparts. In addition, PSPs
              evoked in neurons of animals less than 1 week old did not contain
              inhibitory postsynaptic components. These physiological features
              of immature neocortical neurons help explain the pattern of
              epileptogenesis in young animals. When neonatal cortical slices
              were exposed to the gamma-aminobutyric acid (GABA) antagonists
              penicillin or bicuculline, the frequency of occurrence of
              discharges resembling epileptiform depolarization shifts
              approached that found in mature slices only during the second
              postnatal week. Depolarization shifts at younger ages were less
              stereotyped and more sensitive to stimulus parameters than those
              in mature neurons.",
  journal  = "Brain Res",
  volume   =  431,
  number   =  2,
  pages    = "161--171",
  month    =  aug,
  year     =  1987,
  address  = "Netherlands",
  language = "en"
}

{"_id":"LBqJaBodp6SJHvkmC","bibbaseid":"kriegstein-suppes-prince-cellularandsynapticphysiologyandepileptogenesisofdevelopingratneocorticalneuronsinvitro-1987","author_short":["Kriegstein, A R","Suppes, T","Prince, D A"],"bibdata":{"bibtype":"article","type":"article","title":"Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitro","author":[{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]},{"propositions":[],"lastnames":["Suppes"],"firstnames":["T"],"suffixes":[]},{"propositions":[],"lastnames":["Prince"],"firstnames":["D","A"],"suffixes":[]}],"abstract":"The cellular and synaptic physiology of developing rat neocortical neurons was studied using the in vitro slice method. Rats aged 1-28 days were used for analysis. During the first two postnatal weeks several sequential changes occur in membrane properties and evoked synaptic potentials. Immature neurons had higher input resistances, more linear I-V characteristics, longer membrane time constants, and slower rising and falling phases of action potentials. The developmental increase in rate of rise of the action potential suggests an increasing density of voltage-dependent Na+-channels are inserted in neuronal membranes during postnatal development. The higher input resistance of young cells might be due to their small size and differences in membrane properties. The long time constant indicates a higher specific membrane resistivity of immature neurons. Postsynaptic potentials (PSPs) recorded in young neurons were longer in latency, longer in duration, and more fragile during repetitive activation than their mature counterparts. In addition, PSPs evoked in neurons of animals less than 1 week old did not contain inhibitory postsynaptic components. These physiological features of immature neocortical neurons help explain the pattern of epileptogenesis in young animals. When neonatal cortical slices were exposed to the gamma-aminobutyric acid (GABA) antagonists penicillin or bicuculline, the frequency of occurrence of discharges resembling epileptiform depolarization shifts approached that found in mature slices only during the second postnatal week. Depolarization shifts at younger ages were less stereotyped and more sensitive to stimulus parameters than those in mature neurons.","journal":"Brain Res","volume":"431","number":"2","pages":"161–171","month":"August","year":"1987","address":"Netherlands","language":"en","bibtex":"@ARTICLE{Kriegstein1987-jd,\n title = \"Cellular and synaptic physiology and epileptogenesis of\n developing rat neocortical neurons in vitro\",\n author = \"Kriegstein, A R and Suppes, T and Prince, D A\",\n abstract = \"The cellular and synaptic physiology of developing rat\n neocortical neurons was studied using the in vitro slice method.\n Rats aged 1-28 days were used for analysis. During the first two\n postnatal weeks several sequential changes occur in membrane\n properties and evoked synaptic potentials. Immature neurons had\n higher input resistances, more linear I-V characteristics, longer\n membrane time constants, and slower rising and falling phases of\n action potentials. The developmental increase in rate of rise of\n the action potential suggests an increasing density of\n voltage-dependent Na+-channels are inserted in neuronal membranes\n during postnatal development. The higher input resistance of\n young cells might be due to their small size and differences in\n membrane properties. The long time constant indicates a higher\n specific membrane resistivity of immature neurons. Postsynaptic\n potentials (PSPs) recorded in young neurons were longer in\n latency, longer in duration, and more fragile during repetitive\n activation than their mature counterparts. In addition, PSPs\n evoked in neurons of animals less than 1 week old did not contain\n inhibitory postsynaptic components. These physiological features\n of immature neocortical neurons help explain the pattern of\n epileptogenesis in young animals. When neonatal cortical slices\n were exposed to the gamma-aminobutyric acid (GABA) antagonists\n penicillin or bicuculline, the frequency of occurrence of\n discharges resembling epileptiform depolarization shifts\n approached that found in mature slices only during the second\n postnatal week. Depolarization shifts at younger ages were less\n stereotyped and more sensitive to stimulus parameters than those\n in mature neurons.\",\n journal = \"Brain Res\",\n volume = 431,\n number = 2,\n pages = \"161--171\",\n month = aug,\n year = 1987,\n address = \"Netherlands\",\n language = \"en\"\n}\n\n","author_short":["Kriegstein, A R","Suppes, T","Prince, D A"],"key":"Kriegstein1987-jd","id":"Kriegstein1987-jd","bibbaseid":"kriegstein-suppes-prince-cellularandsynapticphysiologyandepileptogenesisofdevelopingratneocorticalneuronsinvitro-1987","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["cellular","synaptic","physiology","epileptogenesis","developing","rat","neocortical","neurons","vitro","kriegstein","suppes","prince"],"title":"Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitro","year":1987}