Long-term work disability in patients with psoriatic arthritis treated with anti-tumour necrosis factor: a population-based regional Swedish cohort study. Kristensen, L. E., Englund, M., Neovius, M., Askling, J., Jacobsson, L. T. H., & Petersson, I. F. 72(10):1675--1679.
doi  abstract   bibtex   
OBJECTIVE: To study long-term work disability before and after tumour necrosis factor (TNF)-antagonist therapy in patients with psoriatic arthritis (PsA). METHODS: Using the population-based South Swedish Arthritis Treatment Group Register, we identified 191 patients with PsA (median age 43 years, range 18-58 years, 54% men), who between January 2003 and December 2007 started treatment with adalimumab, etanercept or infliximab. We linked data to the Swedish Social Insurance Agency and calculated the proportion of work disability in 30-day intervals from 12 months before the start of treatment until 3 years after. For each patient with PsA we randomly selected four matched reference subjects from the general population. RESULTS: At treatment initiation 67% of the patients with PsA were work disabled-that is, either on sick leave (41.5%) or receiving a disability pension (25.3%). Patients sustaining treatment were, on average, work disabled 12.5 days a month at treatment initiation declining to 10.6 days a month after 3 years of treatment. Patients for whom the first treatment course failed were work disabled 16.5 days at treatment start decreasing to 15.6 days after 3 years. The background population were 2.5 days and 3.0 days off work each month, respectively. Regression modelling identified prior work disability status, anti-TNF treatment failure, higher age, female gender and longer disease duration as significant predictors of working disability. CONCLUSIONS: There was a decline in net work disability after initiation of anti-TNF treatment in patients with PsA. Patients withdrawing from treatment had a 50% increased risk of being work disabled. Prior work disability, higher age, female gender and longer disease duration were also associated with long-term work disability.
@article{kristensen_long-term_2013,
	title = {Long-term work disability in patients with psoriatic arthritis treated with anti-tumour necrosis factor: a population-based regional Swedish cohort study.},
	volume = {72},
	issn = {1468-2060 0003-4967},
	doi = {10.1136/annrheumdis-2012-202229},
	abstract = {{OBJECTIVE}: To study long-term work disability before and after tumour necrosis factor ({TNF})-antagonist therapy in patients with psoriatic arthritis ({PsA}). {METHODS}: Using the population-based South Swedish Arthritis Treatment Group Register, we identified 191 patients with {PsA} (median age 43 years, range 18-58 years, 54\% men), who between January 2003 and December 2007 started treatment with adalimumab, etanercept or infliximab. We linked data to the Swedish Social Insurance Agency and calculated the proportion of work disability in 30-day intervals from 12 months before the start of treatment until 3 years after. For each patient with {PsA} we randomly selected four matched reference subjects from the general population. {RESULTS}: At treatment initiation 67\% of the patients with {PsA} were work disabled-that is, either on sick leave (41.5\%) or receiving a disability pension (25.3\%). Patients sustaining treatment were, on average, work  disabled 12.5 days a month at treatment initiation declining to 10.6 days a month after 3 years of treatment. Patients for whom the first treatment course failed were work disabled 16.5 days at treatment start decreasing to 15.6 days after 3 years. The background population were 2.5 days and 3.0 days off work each month,  respectively. Regression modelling identified prior work disability status, anti-{TNF} treatment failure, higher age, female gender and longer disease duration as significant predictors of working disability. {CONCLUSIONS}: There was a decline in net work disability after initiation of anti-{TNF} treatment in patients with {PsA}. Patients withdrawing from treatment had a 50\% increased risk of being work disabled. Prior work disability, higher age, female gender and longer disease duration were also associated with long-term work disability.},
	pages = {1675--1679},
	number = {10},
	journaltitle = {Annals of the rheumatic diseases},
	shortjournal = {Ann Rheum Dis},
	author = {Kristensen, Lars Erik and Englund, Martin and Neovius, Martin and Askling, Johan and Jacobsson, Lennart T. H. and Petersson, Ingemar F.},
	date = {2013-10},
	pmid = {23148309},
	keywords = {Adalimumab, Adolescent, Adult, Age Factors, Antibodies, Monoclonal, Humanized/therapeutic use, Antibodies, Monoclonal/therapeutic use, Antirheumatic Agents/*therapeutic use, Anti-{TNF}, Arthritis, Psoriatic/drug therapy/epidemiology/*rehabilitation, Cohort Studies, Disability Evaluation, Economic Evaluations, {EPIDEMIOLOGY}, Etanercept, Female, Humans, Immunoglobulin G/therapeutic use, Infliximab, Male, Middle Aged, Pain Measurement/methods, Pensions/statistics \& numerical data, Psoriatic Arthritis, Receptors, Tumor Necrosis Factor/therapeutic use, Severity of Illness Index, Sex Factors, Sick Leave/statistics \& numerical data, Sweden/epidemiology, {TNF}-alpha, Treatment Failure, Tumor Necrosis Factor-alpha/*antagonists \& inhibitors, Young Adult}
}
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