@article{kritas_relationship_2014,
	title = {Relationship between serotonin and mast cells: inhibitory effect of anti-serotonin},
	volume = {28},
	issn = {0393-974X},
	shorttitle = {Relationship between serotonin and mast cells},
	abstract = {Serotonin (5-HT) is an important neurotransmitter that acts in both central and peripheral nervous system, and has an impact on cell proliferation, migration and apoptosis. 5HT exerts its effects via several receptors. Treatment with anti-5-HT receptors diminish the severity of contact allergy in experimental animals, an effect mediated by mast cells; while an agonist reduces the stress level and relieves pruritus in patients with atopic dermatitis. Mast cells are important for both innate and adaptive immunity and they are activated by cross-linking of FceRI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. Serotonin is present in murine mucosal mast cells and some authors reported that human mast cells may also contain serotonin, especially in subjects with mastocytosis. Here we report the interrelationship between mast cells, serotonin and its receptor inhibitor.},
	language = {eng},
	number = {3},
	journal = {Journal of Biological Regulators and Homeostatic Agents},
	author = {Kritas, S. K. and Saggini, A. and Cerulli, G. and Caraffa, A. and Antinolfi, P. and Pantalone, A. and Rosati, M. and Tei, M. and Speziali, A. and Saggini, R. and Conti, P.},
	month = sep,
	year = {2014},
	pmid = {25316126},
	keywords = {Adaptive Immunity, Animals, Humans, Immunity, Innate, Immunity, Mucosal, Immunoglobulin E, Inflammation Mediators, Mast Cells, Mice, Receptors, IgE, Receptors, Serotonin, Serotonin, Serotonin Antagonists},
	pages = {377--380},
}

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Treatment with anti-5-HT receptors diminish the severity of contact allergy in experimental animals, an effect mediated by mast cells; while an agonist reduces the stress level and relieves pruritus in patients with atopic dermatitis. Mast cells are important for both innate and adaptive immunity and they are activated by cross-linking of FceRI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. Serotonin is present in murine mucosal mast cells and some authors reported that human mast cells may also contain serotonin, especially in subjects with mastocytosis. 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Treatment with anti-5-HT receptors diminish the severity of contact allergy in experimental animals, an effect mediated by mast cells; while an agonist reduces the stress level and relieves pruritus in patients with atopic dermatitis. Mast cells are important for both innate and adaptive immunity and they are activated by cross-linking of FceRI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. Serotonin is present in murine mucosal mast cells and some authors reported that human mast cells may also contain serotonin, especially in subjects with mastocytosis. Here we report the interrelationship between mast cells, serotonin and its receptor inhibitor.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Biological Regulators and Homeostatic Agents},\n\tauthor = {Kritas, S. 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