Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin. Kudo, F. & Eguchi, T. In volume 459, of Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates, pages 493--519. Academic Press, 2009. ![Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Butirosin and neomycin belong to a family of clinically valuable 2‐deoxystreptamine (2DOS)‐containing aminoglycoside antibiotics. The biosynthetic gene clusters for butirosin and neomycin were identified in 2000 and in 2005, respectively. In recent years, most of the enzymes encoded in the gene clusters have been characterized, and thus almost all the biosynthetic steps leading to the final antibiotics have been understood. This knowledge could shed light on the complex biosynthetic pathways for other related structurally diverse aminoglycoside antibiotics. In this chapter, the enzymatic reactions in the biosynthesis of butirosin and neomycin are reviewed step by step.
@incollection{kudo_chapter_2009,
series = {Complex {Enzymes} in {Microbial} {Natural} {Product} {Biosynthesis}, {Part} {B}: {Polyketides}, {Aminocoumarins} and {Carbohydrates}},
title = {Chapter 20 {Biosynthetic} {Enzymes} for the {Aminoglycosides} {Butirosin} and {Neomycin}},
volume = {459},
url = {http://www.sciencedirect.com/science/article/pii/S0076687909046205},
abstract = {Butirosin and neomycin belong to a family of clinically valuable 2‐deoxystreptamine (2DOS)‐containing aminoglycoside antibiotics. The biosynthetic gene clusters for butirosin and neomycin were identified in 2000 and in 2005, respectively. In recent years, most of the enzymes encoded in the gene clusters have been characterized, and thus almost all the biosynthetic steps leading to the final antibiotics have been understood. This knowledge could shed light on the complex biosynthetic pathways for other related structurally diverse aminoglycoside antibiotics. In this chapter, the enzymatic reactions in the biosynthesis of butirosin and neomycin are reviewed step by step.},
urldate = {2016-08-11TZ},
publisher = {Academic Press},
author = {Kudo, Fumitaka and Eguchi, Tadashi},
editor = {Enzymology, BT - Methods in},
year = {2009},
pages = {493--519}
}
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