@article{kuo_as1411_2014,
	title = {{AS1411} aptamer-conjugated {Gd2O3}:{Eu} nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging},
	volume = {7},
	issn = {19980000},
	doi = {10.1007/s12274-014-0420-4},
	abstract = {Europium-doped gadolinium oxide (Gd2O3:Eu) nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolintargeted AS1411 aptamer to form functionalized target-specific Gd2O3:Eu nanoparticles (A-GdO:Eu nanoparticles). The A-GdO:Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO:Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T 1 contrast and strong computed tomography (CT) signal, the A-GdO:Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance (MR) molecular imaging. Animal experiments also show that the A-GdO:Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO:Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO:Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future. [Figure not available: see fulltext.] © 2014 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.},
	number = {5},
	journal = {Nano Research},
	author = {Kuo, Tsungrong and Lai, Weiyun and Li, Chenghung and Wun, Yanjhan and Chang, Huancheng and Chen, Jinnshiun and Yang, Panchyr and Chen, Chiachun},
	year = {2014},
	keywords = {aptamer, contrast agent, molecular imaging, nanoparticles synthesis},
	pages = {658--669},
}

{"_id":"dSHnD62wbsXoC5d82","bibbaseid":"kuo-lai-li-wun-chang-chen-yang-chen-as1411aptamerconjugatedgd2o3eunanoparticlesfortargetspecificcomputedtomographymagneticresonancefluorescencemolecularimaging-2014","author_short":["Kuo, T.","Lai, W.","Li, C.","Wun, Y.","Chang, H.","Chen, J.","Yang, P.","Chen, C."],"bibdata":{"bibtype":"article","type":"article","title":"AS1411 aptamer-conjugated Gd2O3:Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging","volume":"7","issn":"19980000","doi":"10.1007/s12274-014-0420-4","abstract":"Europium-doped gadolinium oxide (Gd2O3:Eu) nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolintargeted AS1411 aptamer to form functionalized target-specific Gd2O3:Eu nanoparticles (A-GdO:Eu nanoparticles). The A-GdO:Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO:Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T 1 contrast and strong computed tomography (CT) signal, the A-GdO:Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance (MR) molecular imaging. Animal experiments also show that the A-GdO:Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO:Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO:Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future. [Figure not available: see fulltext.] © 2014 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.","number":"5","journal":"Nano Research","author":[{"propositions":[],"lastnames":["Kuo"],"firstnames":["Tsungrong"],"suffixes":[]},{"propositions":[],"lastnames":["Lai"],"firstnames":["Weiyun"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Chenghung"],"suffixes":[]},{"propositions":[],"lastnames":["Wun"],"firstnames":["Yanjhan"],"suffixes":[]},{"propositions":[],"lastnames":["Chang"],"firstnames":["Huancheng"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Jinnshiun"],"suffixes":[]},{"propositions":[],"lastnames":["Yang"],"firstnames":["Panchyr"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Chiachun"],"suffixes":[]}],"year":"2014","keywords":"aptamer, contrast agent, molecular imaging, nanoparticles synthesis","pages":"658–669","bibtex":"@article{kuo_as1411_2014,\n\ttitle = {{AS1411} aptamer-conjugated {Gd2O3}:{Eu} nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging},\n\tvolume = {7},\n\tissn = {19980000},\n\tdoi = {10.1007/s12274-014-0420-4},\n\tabstract = {Europium-doped gadolinium oxide (Gd2O3:Eu) nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolintargeted AS1411 aptamer to form functionalized target-specific Gd2O3:Eu nanoparticles (A-GdO:Eu nanoparticles). The A-GdO:Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO:Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T 1 contrast and strong computed tomography (CT) signal, the A-GdO:Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance (MR) molecular imaging. Animal experiments also show that the A-GdO:Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO:Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO:Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future. [Figure not available: see fulltext.] © 2014 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.},\n\tnumber = {5},\n\tjournal = {Nano Research},\n\tauthor = {Kuo, Tsungrong and Lai, Weiyun and Li, Chenghung and Wun, Yanjhan and Chang, Huancheng and Chen, Jinnshiun and Yang, Panchyr and Chen, Chiachun},\n\tyear = {2014},\n\tkeywords = {aptamer, contrast agent, molecular imaging, nanoparticles synthesis},\n\tpages = {658--669},\n}\n\n\n\n","author_short":["Kuo, T.","Lai, W.","Li, C.","Wun, Y.","Chang, H.","Chen, J.","Yang, P.","Chen, C."],"key":"kuo_as1411_2014-1","id":"kuo_as1411_2014-1","bibbaseid":"kuo-lai-li-wun-chang-chen-yang-chen-as1411aptamerconjugatedgd2o3eunanoparticlesfortargetspecificcomputedtomographymagneticresonancefluorescencemolecularimaging-2014","role":"author","urls":{},"keyword":["aptamer","contrast agent","molecular imaging","nanoparticles synthesis"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/FRGBergamini","dataSources":["o2mL7kG99iAQPpNRJ"],"keywords":["aptamer","contrast agent","molecular imaging","nanoparticles synthesis"],"search_terms":["as1411","aptamer","conjugated","gd2o3","nanoparticles","target","specific","computed","tomography","magnetic","resonance","fluorescence","molecular","imaging","kuo","lai","li","wun","chang","chen","yang","chen"],"title":"AS1411 aptamer-conjugated Gd2O3:Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging","year":2014}