Deep brain stimulation and climbing fiber synaptic pathology in essential tremor. Kuo, S., Lin, C., Wang, J., Liou, J., Pan, M., Louis, R. J., Wu, W., Gutierrez, J., Louis, E. D., & Faust, P. L. Annals of Neurology, 80(3):461–465, September, 2016. doi abstract bibtex Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461-465.
@article{kuo_deep_2016,
title = {Deep brain stimulation and climbing fiber synaptic pathology in essential tremor},
volume = {80},
issn = {1531-8249},
doi = {10.1002/ana.24728},
abstract = {Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461-465.},
language = {eng},
number = {3},
journal = {Annals of Neurology},
author = {Kuo, Sheng-Han and Lin, Chi-Ying and Wang, Jie and Liou, Jyun-You and Pan, Ming-Kai and Louis, Ravi J. and Wu, Wei-Pu and Gutierrez, Jesus and Louis, Elan D. and Faust, Phyllis L.},
month = sep,
year = {2016},
pmid = {27422481},
pmcid = {PMC5016237},
keywords = {Aged, Aged, 80 and over, Cerebellar Diseases, Deep Brain Stimulation, Essential Tremor, Female, Humans, Male, Nerve Fibers, Severity of Illness Index, Synapses},
pages = {461--465},
}
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We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. 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