Large‐scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents. Kurth, F., Schijven, D., Van Den Heuvel, O. A., Hoogman, M., Van Rooij, D., Stein, D. J., Buitelaar, J. K., Bölte, S., Auzias, G., Kushki, A., Venkatasubramanian, G., Rubia, K., Bollmann, S., Isaksson, J., Jaspers‐Fayer, F., Marsh, R., Batistuzzo, M. C., Arnold, P. D., Bressan, R. A., Stewart, S. E., Gruner, P., Sorensen, L., Pan, P. M., Silk, T. J., Gur, R. C., Cubillo, A. I., Haavik, J., O'Gorman Tuura, R. L., Hartman, C. A., Calvo, R., McGrath, J., Calderoni, S., Jackowski, A., Chantiluke, K. C., Satterthwaite, T. D., Busatto, G. F., Nigg, J. T., Gur, R. E., Retico, A., Tosetti, M., Gallagher, L., Szeszko, P. R., Neufeld, J., Ortiz, A. E., Ghisleni, C., Lazaro, L., Hoekstra, P. J., Anagnostou, E., Hoekstra, L., Simpson, B., Plessen, J. K., Deruelle, C., Soreni, N., James, A., Narayanaswamy, J., Reddy, J. Y., Fitzgerald, J., Bellgrove, M. A., Salum, G. A., Janssen, J., Muratori, F., Vila, M., Giral, M. G., Ameis, S. H., Bosco, P., Remnélius, K. L., Huyser, C., Pariente, J. C., Jalbrzikowski, M., Rosa, P. G., O'Hearn, K. M., Ehrlich, S., Mollon, J., Zugman, A., Christakou, A., Arango, C., Fisher, S. E., Kong, X., Franke, B., Medland, S. E., Thomopoulos, S. I., Jahanshad, N., Glahn, D. C., Thompson, P. M., Francks, C., & Luders, E. Human Brain Mapping, 45(11):e26754, August, 2024.
Large‐scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents [link]Paper  doi  abstract   bibtex   
Abstract Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date ( n  = 4265), aged 1–18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta‐Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.
@article{kurth_largescale_2024,
	title = {Large‐scale analysis of structural brain asymmetries during neurodevelopment: {Associations} with age and sex in 4265 children and adolescents},
	volume = {45},
	issn = {1065-9471, 1097-0193},
	shorttitle = {Large‐scale analysis of structural brain asymmetries during neurodevelopment},
	url = {https://onlinelibrary.wiley.com/doi/10.1002/hbm.26754},
	doi = {10.1002/hbm.26754},
	abstract = {Abstract
            
              Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (
              n
               = 4265), aged 1–18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta‐Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.},
	language = {en},
	number = {11},
	urldate = {2025-04-02},
	journal = {Human Brain Mapping},
	author = {Kurth, F. and Schijven, D. and Van Den Heuvel, O. A. and Hoogman, M. and Van Rooij, D. and Stein, D. J. and Buitelaar, J. K. and Bölte, S. and Auzias, G. and Kushki, A. and Venkatasubramanian, G. and Rubia, K. and Bollmann, S. and Isaksson, J. and Jaspers‐Fayer, F. and Marsh, R. and Batistuzzo, M. C. and Arnold, P. D. and Bressan, R. A. and Stewart, S. E. and Gruner, P. and Sorensen, L. and Pan, P. M. and Silk, T. J. and Gur, R. C. and Cubillo, A. I. and Haavik, J. and O'Gorman Tuura, R. L. and Hartman, C. A. and Calvo, R. and McGrath, J. and Calderoni, S. and Jackowski, A. and Chantiluke, K. C. and Satterthwaite, T. D. and Busatto, G. F. and Nigg, J. T. and Gur, R. E. and Retico, A. and Tosetti, M. and Gallagher, L. and Szeszko, P. R. and Neufeld, J. and Ortiz, A. E. and Ghisleni, C. and Lazaro, L. and Hoekstra, P. J. and Anagnostou, E. and Hoekstra, L. and Simpson, B. and Plessen, J. K. and Deruelle, C. and Soreni, N. and James, A. and Narayanaswamy, J. and Reddy, J. Y. and Fitzgerald, J. and Bellgrove, M. A. and Salum, G. A. and Janssen, J. and Muratori, F. and Vila, M. and Giral, M. Garcia and Ameis, S. H. and Bosco, P. and Remnélius, K. Lundin and Huyser, C. and Pariente, J. C. and Jalbrzikowski, M. and Rosa, P. G. and O'Hearn, K. M. and Ehrlich, S. and Mollon, J. and Zugman, A. and Christakou, A. and Arango, C. and Fisher, S. E. and Kong, X. and Franke, B. and Medland, S. E. and Thomopoulos, S. I. and Jahanshad, N. and Glahn, D. C. and Thompson, P. M. and Francks, C. and Luders, E.},
	month = aug,
	year = {2024},
	pages = {e26754},
}
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