A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light. Kutomi, O., Yamamoto, R., Hirose, K., Mizuno, K., Nakagiri, Y., Imai, H., Noga, A., Obbineni, J. M., Zimmermann, N., Nakajima, M., Shibata, D., Shibata, M., Shiba, K., Kita, M., Kigoshi, H., Tanaka, Y., Yamasaki, Y., Asahina, Y., Song, C., Nomura, M., Nomura, M., Nakajima, A., Nakachi, M., Yamada, L., Nakazawa, S., Sawada, H., Murata, K., Mitsuoka, K., Ishikawa, T., Wakabayashi, K., Kon, T., & Inaba, K. Science Advances, 7(9):eabf3621, February, 2021. ![A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule. Chlamydomonas lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.
@article{kutomi_dynein-associated_2021,
title = {A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light},
volume = {7},
issn = {2375-2548},
url = {https://advances.sciencemag.org/lookup/doi/10.1126/sciadv.abf3621},
doi = {10.1126/sciadv.abf3621},
abstract = {Light-responsive regulation of ciliary motility is known to be conducted through modulation of dyneins, but the mechanism is not fully understood. Here, we report a novel subunit of the two-headed f/I1 inner arm dynein, named DYBLUP, in animal spermatozoa and a unicellular green alga. This subunit contains a BLUF (sensors of blue light using FAD) domain that appears to directly modulate dynein activity in response to light. DYBLUP (dynein-associated BLUF protein) mediates the connection between the f/I1 motor domain and the tether complex that links the motor to the doublet microtubule.
Chlamydomonas
lacking the DYBLUP ortholog shows both positive and negative phototaxis but becomes acclimated and attracted to high-intensity blue light. These results suggest a mechanism to avoid toxic strong light via direct photoregulation of dyneins.},
language = {en},
number = {9},
urldate = {2021-07-27},
journal = {Science Advances},
author = {Kutomi, Osamu and Yamamoto, Ryosuke and Hirose, Keiko and Mizuno, Katsutoshi and Nakagiri, Yuuhei and Imai, Hiroshi and Noga, Akira and Obbineni, Jagan Mohan and Zimmermann, Noemi and Nakajima, Masako and Shibata, Daisuke and Shibata, Misa and Shiba, Kogiku and Kita, Masaki and Kigoshi, Hideo and Tanaka, Yui and Yamasaki, Yuya and Asahina, Yuma and Song, Chihong and Nomura, Mami and Nomura, Mamoru and Nakajima, Ayako and Nakachi, Mia and Yamada, Lixy and Nakazawa, Shiori and Sawada, Hitoshi and Murata, Kazuyoshi and Mitsuoka, Kaoru and Ishikawa, Takashi and Wakabayashi, Ken-ichi and Kon, Takahide and Inaba, Kazuo},
month = feb,
year = {2021},
pages = {eabf3621},
}
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