@article{kyndi_high_2009,
	title = {High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer: {A} subgroup analysis of {DBCG} 82 b\&c},
	volume = {90},
	issn = {0167-8140},
	shorttitle = {High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer},
	url = {http://www.sciencedirect.com/science/article/pii/S0167814008002351},
	doi = {10.1016/j.radonc.2008.04.014},
	abstract = {Background and purpose 
International consensus reports recommend postmastectomy radiotherapy only to patients at high risk of a local recurrence (LR). 
Materials and methods 
The present analysis included 1000 out of 3083 high-risk breast cancer patients randomly assigned to postmastectomy radiotherapy in the DBCG82 b\&c trials. Tissue microarrays had been constructed and sections stained for estrogen, progesterone and HER2 receptors. Median potential follow-up time was 17 years. Endpoints were LR as isolated first event, breast cancer mortality and overall mortality. 
Results 
Among patients randomly assigned to not receive radiotherapy, three prognostic subgroups of LR risk were found. “The good” defined by at least four out of five favorable criteria (⩽3 positive nodes, tumor size \<2 cm, Grade 1 malignancy, estrogen or progesterone receptor positive, HER2 negative), “the Poor” defined by at least two out of three un-favorable criteria (\>3 positive nodes, tumor size \>5 cm, Grade 3 malignancy) and finally “the Intermediate” the group in between. The smallest absolute reduction in 5-year LR probability (11\%) after radiotherapy was seen for the good prognosis group. A similar absolute reduction in 15-year breast cancer mortality after radiotherapy (11\%) was seen. The largest absolute reduction in 5-year LR probability after radiotherapy was seen for the poor prognosis group (36\%). However, this large LR reduction did not translate into any reduction in 15-year breast cancer mortality (0\%). 
Conclusion 
Translation of LR reduction into breast cancer mortality reduction after postmastectomy radiotherapy to high-risk breast cancer patients seems to be heterogeneous, with the largest translation occurring within the good prognosis group.},
	number = {1},
	urldate = {2013-04-13},
	journal = {Radiotherapy and Oncology},
	author = {Kyndi, Marianne and Overgaard, Marie and Nielsen, Hanne M. and Sørensen, Flemming B. and Knudsen, Helle and Overgaard, Jens},
	month = jan,
	year = {2009},
	keywords = {Breast cancer, Local recurrence, Postmastectomy radiotherapy, Randomized study, Tissue microarray},
	pages = {74--79},
	file = {ScienceDirect Full Text PDF:files/38266/Kyndi et al. - 2009 - High local recurrence risk is not associated with .pdf:application/pdf}
}

{"_id":"8QjjGBdottgeM9fNf","bibbaseid":"kyndi-overgaard-nielsen-srensen-knudsen-overgaard-highlocalrecurrenceriskisnotassociatedwithlargesurvivalreductionafterpostmastectomyradiotherapyinhighriskbreastcancerasubgroupanalysisofdbcg82bc-2009","downloads":0,"creationDate":"2016-09-09T06:27:31.720Z","title":"High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer: A subgroup analysis of DBCG 82 b&c","author_short":["Kyndi, M.","Overgaard, M.","Nielsen, H. M.","Sørensen, F. B.","Knudsen, H.","Overgaard, J."],"year":2009,"bibtype":"article","biburl":"https://www.sfu.ca/~howlett/howlett16.bib","bibdata":{"bibtype":"article","type":"article","title":"High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer: A subgroup analysis of DBCG 82 b&c","volume":"90","issn":"0167-8140","shorttitle":"High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer","url":"http://www.sciencedirect.com/science/article/pii/S0167814008002351","doi":"10.1016/j.radonc.2008.04.014","abstract":"Background and purpose International consensus reports recommend postmastectomy radiotherapy only to patients at high risk of a local recurrence (LR). Materials and methods The present analysis included 1000 out of 3083 high-risk breast cancer patients randomly assigned to postmastectomy radiotherapy in the DBCG82 b&c trials. Tissue microarrays had been constructed and sections stained for estrogen, progesterone and HER2 receptors. Median potential follow-up time was 17 years. Endpoints were LR as isolated first event, breast cancer mortality and overall mortality. Results Among patients randomly assigned to not receive radiotherapy, three prognostic subgroups of LR risk were found. “The good” defined by at least four out of five favorable criteria (⩽3 positive nodes, tumor size <2 cm, Grade 1 malignancy, estrogen or progesterone receptor positive, HER2 negative), “the Poor” defined by at least two out of three un-favorable criteria (>3 positive nodes, tumor size >5 cm, Grade 3 malignancy) and finally “the Intermediate” the group in between. The smallest absolute reduction in 5-year LR probability (11%) after radiotherapy was seen for the good prognosis group. A similar absolute reduction in 15-year breast cancer mortality after radiotherapy (11%) was seen. The largest absolute reduction in 5-year LR probability after radiotherapy was seen for the poor prognosis group (36%). However, this large LR reduction did not translate into any reduction in 15-year breast cancer mortality (0%). Conclusion Translation of LR reduction into breast cancer mortality reduction after postmastectomy radiotherapy to high-risk breast cancer patients seems to be heterogeneous, with the largest translation occurring within the good prognosis group.","number":"1","urldate":"2013-04-13","journal":"Radiotherapy and Oncology","author":[{"propositions":[],"lastnames":["Kyndi"],"firstnames":["Marianne"],"suffixes":[]},{"propositions":[],"lastnames":["Overgaard"],"firstnames":["Marie"],"suffixes":[]},{"propositions":[],"lastnames":["Nielsen"],"firstnames":["Hanne","M."],"suffixes":[]},{"propositions":[],"lastnames":["Sørensen"],"firstnames":["Flemming","B."],"suffixes":[]},{"propositions":[],"lastnames":["Knudsen"],"firstnames":["Helle"],"suffixes":[]},{"propositions":[],"lastnames":["Overgaard"],"firstnames":["Jens"],"suffixes":[]}],"month":"January","year":"2009","keywords":"Breast cancer, Local recurrence, Postmastectomy radiotherapy, Randomized study, Tissue microarray","pages":"74--79","file":"ScienceDirect Full Text PDF:files/38266/Kyndi et al. - 2009 - High local recurrence risk is not associated with .pdf:application/pdf","bibtex":"@article{kyndi_high_2009,\n\ttitle = {High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer: {A} subgroup analysis of {DBCG} 82 b\\&c},\n\tvolume = {90},\n\tissn = {0167-8140},\n\tshorttitle = {High local recurrence risk is not associated with large survival reduction after postmastectomy radiotherapy in high-risk breast cancer},\n\turl = {http://www.sciencedirect.com/science/article/pii/S0167814008002351},\n\tdoi = {10.1016/j.radonc.2008.04.014},\n\tabstract = {Background and purpose \nInternational consensus reports recommend postmastectomy radiotherapy only to patients at high risk of a local recurrence (LR). \nMaterials and methods \nThe present analysis included 1000 out of 3083 high-risk breast cancer patients randomly assigned to postmastectomy radiotherapy in the DBCG82 b\\&c trials. Tissue microarrays had been constructed and sections stained for estrogen, progesterone and HER2 receptors. Median potential follow-up time was 17 years. Endpoints were LR as isolated first event, breast cancer mortality and overall mortality. \nResults \nAmong patients randomly assigned to not receive radiotherapy, three prognostic subgroups of LR risk were found. “The good” defined by at least four out of five favorable criteria (⩽3 positive nodes, tumor size \\<2 cm, Grade 1 malignancy, estrogen or progesterone receptor positive, HER2 negative), “the Poor” defined by at least two out of three un-favorable criteria (\\>3 positive nodes, tumor size \\>5 cm, Grade 3 malignancy) and finally “the Intermediate” the group in between. The smallest absolute reduction in 5-year LR probability (11\\%) after radiotherapy was seen for the good prognosis group. A similar absolute reduction in 15-year breast cancer mortality after radiotherapy (11\\%) was seen. The largest absolute reduction in 5-year LR probability after radiotherapy was seen for the poor prognosis group (36\\%). However, this large LR reduction did not translate into any reduction in 15-year breast cancer mortality (0\\%). \nConclusion \nTranslation of LR reduction into breast cancer mortality reduction after postmastectomy radiotherapy to high-risk breast cancer patients seems to be heterogeneous, with the largest translation occurring within the good prognosis group.},\n\tnumber = {1},\n\turldate = {2013-04-13},\n\tjournal = {Radiotherapy and Oncology},\n\tauthor = {Kyndi, Marianne and Overgaard, Marie and Nielsen, Hanne M. and Sørensen, Flemming B. and Knudsen, Helle and Overgaard, Jens},\n\tmonth = jan,\n\tyear = {2009},\n\tkeywords = {Breast cancer, Local recurrence, Postmastectomy radiotherapy, Randomized study, Tissue microarray},\n\tpages = {74--79},\n\tfile = {ScienceDirect Full Text PDF:files/38266/Kyndi et al. - 2009 - High local recurrence risk is not associated with .pdf:application/pdf}\n}\n\n","author_short":["Kyndi, M.","Overgaard, M.","Nielsen, H. M.","Sørensen, F. B.","Knudsen, H.","Overgaard, J."],"key":"kyndi_high_2009","id":"kyndi_high_2009","bibbaseid":"kyndi-overgaard-nielsen-srensen-knudsen-overgaard-highlocalrecurrenceriskisnotassociatedwithlargesurvivalreductionafterpostmastectomyradiotherapyinhighriskbreastcancerasubgroupanalysisofdbcg82bc-2009","role":"author","urls":{"Paper":"http://www.sciencedirect.com/science/article/pii/S0167814008002351"},"keyword":["Breast cancer","Local recurrence","Postmastectomy radiotherapy","Randomized study","Tissue microarray"],"downloads":0},"search_terms":["high","local","recurrence","risk","associated","large","survival","reduction","postmastectomy","radiotherapy","high","risk","breast","cancer","subgroup","analysis","dbcg","kyndi","overgaard","nielsen","sørensen","knudsen","overgaard"],"keywords":["breast cancer","local recurrence","postmastectomy radiotherapy","randomized study","tissue microarray"],"authorIDs":[],"dataSources":["Bn7xRaKMY43f7hFwh"]}