The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets. Lago, S. G. & Bahn, S. npj Genomic Medicine, 7(1):1–13, March, 2022. Number: 1 Publisher: Nature Publishing Group![The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex There have been no new drugs for the treatment of schizophrenia in several decades and treatment resistance represents a major unmet clinical need. The drugs that exist are based on serendipitous clinical observations rather than an evidence-based understanding of disease pathophysiology. In the present review, we address these bottlenecks by integrating common, rare, and expression-related schizophrenia risk genes with knowledge of the druggability of the human genome as a whole. We highlight novel drug repurposing opportunities, clinical trial candidates which are supported by genetic evidence, and unexplored therapeutic opportunities in the lesser-known regions of the schizophrenia genome. By identifying translational gaps and opportunities across the schizophrenia disease space, we discuss a framework for translating increasingly well-powered genetic association studies into personalized treatments for schizophrenia and initiating the vital task of characterizing clinically relevant drug targets in underexplored regions of the human genome.
@article{lago_druggable_2022,
title = {The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets},
volume = {7},
copyright = {2022 The Author(s)},
issn = {2056-7944},
shorttitle = {The druggable schizophrenia genome},
url = {https://www.nature.com/articles/s41525-022-00290-4},
doi = {10.1038/s41525-022-00290-4},
abstract = {There have been no new drugs for the treatment of schizophrenia in several decades and treatment resistance represents a major unmet clinical need. The drugs that exist are based on serendipitous clinical observations rather than an evidence-based understanding of disease pathophysiology. In the present review, we address these bottlenecks by integrating common, rare, and expression-related schizophrenia risk genes with knowledge of the druggability of the human genome as a whole. We highlight novel drug repurposing opportunities, clinical trial candidates which are supported by genetic evidence, and unexplored therapeutic opportunities in the lesser-known regions of the schizophrenia genome. By identifying translational gaps and opportunities across the schizophrenia disease space, we discuss a framework for translating increasingly well-powered genetic association studies into personalized treatments for schizophrenia and initiating the vital task of characterizing clinically relevant drug targets in underexplored regions of the human genome.},
language = {en},
number = {1},
urldate = {2022-05-27},
journal = {npj Genomic Medicine},
author = {Lago, Santiago G. and Bahn, Sabine},
month = mar,
year = {2022},
note = {Number: 1
Publisher: Nature Publishing Group},
keywords = {Genome, Pharmaceutics, Schizophrenia, Target identification},
pages = {1--13},
}
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