Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features. Laidi, C., d'Albis , M., Wessa, M., Linke, J., Phillips, M. L., Delavest, M., Bellivier, F., Versace, A., Almeida, J., Sarrazin, S., Poupon, C., Le Dudal, K., Daban, C., Hamdani, N., Leboyer, M., & Houenou, J. Acta Psychiatrica Scandinavica, 131(3):223–233, March, 2015.
Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features [link]Paper  doi  abstract   bibtex   
OBJECTIVE There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum is likely to be involved in the physiopathology of both bipolar disorder and schizophrenia. The objective of our study was to compare cerebellar size between patients with bipolar disorder, patients with schizophrenia, and healthy controls in a multicenter sample. In addition, we studied the influence of psychotic features on cerebellar size in patients with bipolar disorder. METHOD One hundred and fifteen patients with bipolar I disorder, 32 patients with schizophrenia, and 52 healthy controls underwent 3 Tesla MRI. Automated segmentation of cerebellum was performed using FreeSurfer software. Volumes of cerebellar cortex and white matter were extracted. Analyses of covariance were conducted, and age, sex, and intracranial volume were considered as covariates. RESULTS Bilateral cerebellar cortical volumes were smaller in patients with schizophrenia compared with patients with bipolar I disorder and healthy controls. We found no significant difference of cerebellar volume between bipolar patients with and without psychotic features. No change was evidenced in white matter. CONCLUSION Our results suggest that reduction in cerebellar cortical volume is specific to schizophrenia. Cerebellar dysfunction in bipolar disorder, if present, appears to be more subtle than a reduction in cerebellar volume.
@article{laidi_cerebellar_2015,
	title = {Cerebellar volume in schizophrenia and bipolar {I} disorder with and without psychotic features},
	volume = {131},
	issn = {0001690X},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25430729},
	doi = {10.1111/acps.12363},
	abstract = {OBJECTIVE There is growing evidence that cerebellum plays a crucial role in cognition and emotional regulation. Cerebellum is likely to be involved in the physiopathology of both bipolar disorder and schizophrenia. The objective of our study was to compare cerebellar size between patients with bipolar disorder, patients with schizophrenia, and healthy controls in a multicenter sample. In addition, we studied the influence of psychotic features on cerebellar size in patients with bipolar disorder. METHOD One hundred and fifteen patients with bipolar I disorder, 32 patients with schizophrenia, and 52 healthy controls underwent 3 Tesla MRI. Automated segmentation of cerebellum was performed using FreeSurfer software. Volumes of cerebellar cortex and white matter were extracted. Analyses of covariance were conducted, and age, sex, and intracranial volume were considered as covariates. RESULTS Bilateral cerebellar cortical volumes were smaller in patients with schizophrenia compared with patients with bipolar I disorder and healthy controls. We found no significant difference of cerebellar volume between bipolar patients with and without psychotic features. No change was evidenced in white matter. CONCLUSION Our results suggest that reduction in cerebellar cortical volume is specific to schizophrenia. Cerebellar dysfunction in bipolar disorder, if present, appears to be more subtle than a reduction in cerebellar volume.},
	number = {3},
	urldate = {2018-10-23},
	journal = {Acta Psychiatrica Scandinavica},
	author = {Laidi, C. and d'Albis, M.-A. and Wessa, M. and Linke, J. and Phillips, M. L. and Delavest, M. and Bellivier, F. and Versace, A. and Almeida, J. and Sarrazin, S. and Poupon, C. and Le Dudal, K. and Daban, C. and Hamdani, N. and Leboyer, M. and Houenou, J.},
	month = mar,
	year = {2015},
	pmid = {25430729},
	keywords = {MRI, bipolar disorder, cerebellum, psychosis, schizophrenia},
	pages = {223--233},
}

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