SARS-CoV-2 infection is associated with uncontrolled HIV viral load in non-hospitalized HIV-infected patients from Gugulethu, South Africa. Lambarey, H., Blumenthal, M. J, Chetram, A., Joyimbana, W., Jennings, L., Tincho, M. B, Burgers, W. A, Orrell, C., & Schäfer, G. Viruses, 14(6):1222, Multidisciplinary Digital Publishing Institute, jun, 2022. ![SARS-CoV-2 infection is associated with uncontrolled HIV viral load in non-hospitalized HIV-infected patients from Gugulethu, South Africa [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex In South Africa, high exposure to SARS-CoV-2 occurs primarily in densely populated, low-income communities, which are additionally burdened by highly prevalent Human Immunodeficiency Virus (HIV). With the aim to assess SARS-CoV-2 seroprevalence and its association with HIV-related clinical parameters in non-hospitalized patients likely to be highly exposed to SARS-CoV-2, this observational cross-sectional study was conducted at the Gugulethu Community Health Centre Antiretroviral clinic between October 2020 and June 2021, after the first COVID-19 wave in South Africa and during the second and beginning of the third wave. A total of 150 adult (median age 39 years [range 20–65 years]) HIV-infected patients (69% female; 31% male) were recruited. 95.3% of the cohort was on antiretroviral therapy (ART), had a median CD4 count of 220 cells/µL (range 17–604 cells/µL) and a median HIV viral load (VL) of 49 copies/mL (range 1–1,050,867 copies/mL). Furthermore, 106 patients (70.7%) were SARS-CoV-2 seropositive, and 0% were vaccinated. When stratified for HIV VL, patients with uncontrolled HIV viremia (HIV VL \textgreater 1000 copies/mL) had significantly higher odds of SARS-CoV-2 seropositivity than patients with HIV VL \textless 1000 copies/mL, after adjusting for age, sex and ART status (p = 0.035, adjusted OR 2.961 [95% CI: 1.078–8.133]). Although the cause–effect relationship could not be determined due to the cross-sectional study design, these results point towards a higher risk of SARS-CoV-2 susceptibility among viremic HIV patients, or impaired HIV viral control due to previous co-infection with SARS-CoV-2.
@article{Lambarey2022a,
abstract = {In South Africa, high exposure to SARS-CoV-2 occurs primarily in densely populated, low-income communities, which are additionally burdened by highly prevalent Human Immunodeficiency Virus (HIV). With the aim to assess SARS-CoV-2 seroprevalence and its association with HIV-related clinical parameters in non-hospitalized patients likely to be highly exposed to SARS-CoV-2, this observational cross-sectional study was conducted at the Gugulethu Community Health Centre Antiretroviral clinic between October 2020 and June 2021, after the first COVID-19 wave in South Africa and during the second and beginning of the third wave. A total of 150 adult (median age 39 years [range 20–65 years]) HIV-infected patients (69{\%} female; 31{\%} male) were recruited. 95.3{\%} of the cohort was on antiretroviral therapy (ART), had a median CD4 count of 220 cells/µL (range 17–604 cells/µL) and a median HIV viral load (VL) of 49 copies/mL (range 1–1,050,867 copies/mL). Furthermore, 106 patients (70.7{\%}) were SARS-CoV-2 seropositive, and 0{\%} were vaccinated. When stratified for HIV VL, patients with uncontrolled HIV viremia (HIV VL {\textgreater} 1000 copies/mL) had significantly higher odds of SARS-CoV-2 seropositivity than patients with HIV VL {\textless} 1000 copies/mL, after adjusting for age, sex and ART status (p = 0.035, adjusted OR 2.961 [95{\%} CI: 1.078–8.133]). Although the cause–effect relationship could not be determined due to the cross-sectional study design, these results point towards a higher risk of SARS-CoV-2 susceptibility among viremic HIV patients, or impaired HIV viral control due to previous co-infection with SARS-CoV-2.},
author = {Lambarey, Humaira and Blumenthal, Melissa J and Chetram, Abeen and Joyimbana, Wendy and Jennings, Lauren and Tincho, Marius B and Burgers, Wendy A and Orrell, Catherine and Sch{\"{a}}fer, Georgia},
doi = {10.3390/V14061222},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Lambarey et al. - 2022 - SARS-CoV-2 infection is associated with uncontrolled HIV viral load in non-hospitalized HIV-infected patient(2).pdf:pdf},
issn = {1999-4915},
journal = {Viruses},
keywords = {ART,COVID,CoV,HIV,OA,OA{\_}PMC,PLWH,SARS,South Africa,fund{\_}not{\_}ack,original,viral load},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
month = {jun},
number = {6},
pages = {1222},
pmid = {35746693},
publisher = {Multidisciplinary Digital Publishing Institute},
title = {{SARS-CoV-2 infection is associated with uncontrolled HIV viral load in non-hospitalized HIV-infected patients from Gugulethu, South Africa}},
url = {https://www.mdpi.com/1999-4915/14/6/1222/htm https://www.mdpi.com/1999-4915/14/6/1222},
volume = {14},
year = {2022}
}
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With the aim to assess SARS-CoV-2 seroprevalence and its association with HIV-related clinical parameters in non-hospitalized patients likely to be highly exposed to SARS-CoV-2, this observational cross-sectional study was conducted at the Gugulethu Community Health Centre Antiretroviral clinic between October 2020 and June 2021, after the first COVID-19 wave in South Africa and during the second and beginning of the third wave. A total of 150 adult (median age 39 years [range 20–65 years]) HIV-infected patients (69% female; 31% male) were recruited. 95.3% of the cohort was on antiretroviral therapy (ART), had a median CD4 count of 220 cells/µL (range 17–604 cells/µL) and a median HIV viral load (VL) of 49 copies/mL (range 1–1,050,867 copies/mL). Furthermore, 106 patients (70.7%) were SARS-CoV-2 seropositive, and 0% were vaccinated. When stratified for HIV VL, patients with uncontrolled HIV viremia (HIV VL \\textgreater 1000 copies/mL) had significantly higher odds of SARS-CoV-2 seropositivity than patients with HIV VL \\textless 1000 copies/mL, after adjusting for age, sex and ART status (p = 0.035, adjusted OR 2.961 [95% CI: 1.078–8.133]). 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