Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. Lamontagne, F., Masse, M., Menard, J., Sprague, S., Pinto, R., Heyland, D. K., Cook, D. J., Battista, M., Day, A. G., Guyatt, G. H., Kanji, S., Parke, R., McGuinness, S. P., Tirupakuzhi Vijayaraghavan, B., Annane, D., Cohen, D., Arabi, Y. M., Bolduc, B., Marinoff, N., Rochwerg, B., Millen, T., Meade, M. O., Hand, L., Watpool, I., Porteous, R., Young, P. J., D'Aragon, F., Belley-Cote, E. P., Carbonneau, E., Clarke, F., Maslove, D. M., Hunt, M., Chassé, M., Lebrasseur, M., Lauzier, F., Mehta, S., Quiroz-Martinez, H., Rewa, O. G., Charbonney, E., Seely, A. J. E., Kutsogiannis, D. J., LeBlanc, R., Mekontso-Dessap, A., Mele, T. S., Turgeon, A. F., Wood, G., Kohli, S. S., Shahin, J., Twardowski, P., Adhikari, N. K. J., LOVIT Investigators, & Group, t. C. C. C. T. The New England Journal of Medicine, 386(25):2387–2398, June, 2022.
doi  abstract   bibtex   
BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction. METHODS: In this randomized, placebo-controlled trial, we assigned adults who had been in the ICU for no longer than 24 hours, who had proven or suspected infection as the main diagnosis, and who were receiving a vasopressor to receive an infusion of either vitamin C (at a dose of 50 mg per kilogram of body weight) or matched placebo administered every 6 hours for up to 96 hours. The primary outcome was a composite of death or persistent organ dysfunction (defined by the use of vasopressors, invasive mechanical ventilation, or new renal-replacement therapy) on day 28. RESULTS: A total of 872 patients underwent randomization (435 to the vitamin C group and 437 to the control group). The primary outcome occurred in 191 of 429 patients (44.5%) in the vitamin C group and in 167 of 434 patients (38.5%) in the control group (risk ratio, 1.21; 95% confidence interval [CI], 1.04 to 1.40; P = 0.01). At 28 days, death had occurred in 152 of 429 patients (35.4%) in the vitamin C group and in 137 of 434 patients (31.6%) in the placebo group (risk ratio, 1.17; 95% CI, 0.98 to 1.40) and persistent organ dysfunction in 39 of 429 patients (9.1%) and 30 of 434 patients (6.9%), respectively (risk ratio, 1.30; 95% CI, 0.83 to 2.05). Findings were similar in the two groups regarding organ-dysfunction scores, biomarkers, 6-month survival, health-related quality of life, stage 3 acute kidney injury, and hypoglycemic episodes. In the vitamin C group, one patient had a severe hypoglycemic episode and another had a serious anaphylaxis event. CONCLUSIONS: In adults with sepsis receiving vasopressor therapy in the ICU, those who received intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. (Funded by the Lotte and John Hecht Memorial Foundation; LOVIT ClinicalTrials.gov number, NCT03680274.).
@article{lamontagne_intravenous_2022,
	title = {Intravenous {Vitamin} {C} in {Adults} with {Sepsis} in the {Intensive} {Care} {Unit}},
	volume = {386},
	issn = {1533-4406},
	doi = {10.1056/NEJMoa2200644},
	abstract = {BACKGROUND: Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to the risk of death and organ dysfunction.
METHODS: In this randomized, placebo-controlled trial, we assigned adults who had been in the ICU for no longer than 24 hours, who had proven or suspected infection as the main diagnosis, and who were receiving a vasopressor to receive an infusion of either vitamin C (at a dose of 50 mg per kilogram of body weight) or matched placebo administered every 6 hours for up to 96 hours. The primary outcome was a composite of death or persistent organ dysfunction (defined by the use of vasopressors, invasive mechanical ventilation, or new renal-replacement therapy) on day 28.
RESULTS: A total of 872 patients underwent randomization (435 to the vitamin C group and 437 to the control group). The primary outcome occurred in 191 of 429 patients (44.5\%) in the vitamin C group and in 167 of 434 patients (38.5\%) in the control group (risk ratio, 1.21; 95\% confidence interval [CI], 1.04 to 1.40; P = 0.01). At 28 days, death had occurred in 152 of 429 patients (35.4\%) in the vitamin C group and in 137 of 434 patients (31.6\%) in the placebo group (risk ratio, 1.17; 95\% CI, 0.98 to 1.40) and persistent organ dysfunction in 39 of 429 patients (9.1\%) and 30 of 434 patients (6.9\%), respectively (risk ratio, 1.30; 95\% CI, 0.83 to 2.05). Findings were similar in the two groups regarding organ-dysfunction scores, biomarkers, 6-month survival, health-related quality of life, stage 3 acute kidney injury, and hypoglycemic episodes. In the vitamin C group, one patient had a severe hypoglycemic episode and another had a serious anaphylaxis event.
CONCLUSIONS: In adults with sepsis receiving vasopressor therapy in the ICU, those who received intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. (Funded by the Lotte and John Hecht Memorial Foundation; LOVIT ClinicalTrials.gov number, NCT03680274.).},
	language = {eng},
	number = {25},
	journal = {The New England Journal of Medicine},
	author = {Lamontagne, François and Masse, Marie-Hélène and Menard, Julie and Sprague, Sheila and Pinto, Ruxandra and Heyland, Daren K. and Cook, Deborah J. and Battista, Marie-Claude and Day, Andrew G. and Guyatt, Gordon H. and Kanji, Salmaan and Parke, Rachael and McGuinness, Shay P. and Tirupakuzhi Vijayaraghavan, Bharath-Kumar and Annane, Djillali and Cohen, Dian and Arabi, Yaseen M. and Bolduc, Brigitte and Marinoff, Nicole and Rochwerg, Bram and Millen, Tina and Meade, Maureen O. and Hand, Lori and Watpool, Irene and Porteous, Rebecca and Young, Paul J. and D'Aragon, Frederick and Belley-Cote, Emilie P. and Carbonneau, Elaine and Clarke, France and Maslove, David M. and Hunt, Miranda and Chassé, Michaël and Lebrasseur, Martine and Lauzier, François and Mehta, Sangeeta and Quiroz-Martinez, Hector and Rewa, Oleksa G. and Charbonney, Emmanuel and Seely, Andrew J. E. and Kutsogiannis, Demetrios J. and LeBlanc, Remi and Mekontso-Dessap, Armand and Mele, Tina S. and Turgeon, Alexis F. and Wood, Gordon and Kohli, Sandeep S. and Shahin, Jason and Twardowski, Pawel and Adhikari, Neill K. J. and {LOVIT Investigators and the Canadian Critical Care Trials Group}},
	month = jun,
	year = {2022},
	pmid = {35704292},
	keywords = {Adult, Ascorbic Acid, Humans, Hypoglycemic Agents, Intensive Care Units, Multiple Organ Failure, Quality of Life, Sepsis, Vasoconstrictor Agents, Vitamins},
	pages = {2387--2398},
}
Downloads: 0
About
Documentation
Keywords
Search
Users
Terms and Conditions of Use
Privacy Policy
Sitemap
© BibBase.org 2021