@article{lanata_safety_1996,
	title = {Safety, immunogenicity, and protective efficacy of one and three doses of the tetravalent rhesus rotavirus vaccine in infants in {Lima}, {Peru}},
	volume = {174},
	issn = {0022-1899},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/8699054},
	abstract = {An oral rhesus-human rotavirus tetravalent (RRV-TV) vaccine (10(4) pfu of rhesus rotavirus [type G3] and of 3 human-rhesus reassortants [G1, G2, and G4]) was evaluated in a field trial in Lima, Peru. At 2, 3, and 4 months of age, infants received either a dose of RRV-TV, an initial dose of vaccine followed by a dose of placebo at 3 and 4 months, or a dose of placebo. Rotavirus-specific IgA responses were detected by ELISA in 75\% of the three-dose vaccine group, 59\% of the one-dose vaccine group (P = .05), and 24\% of the placebo group (P {\textless} .001): 64\%, 48\%, and 12\% of each group, respectively, had a neutralizing antibody response to at least 1 serotype. Both one and three doses of vaccine failed to induce a significant level of protection against rotavirus diarrhea; however, they did provide some protection (range, 35\%-66\%) against more severe rotavirus diarrhea, especially for episodes caused by type G1.},
	number = {2},
	urldate = {2010-11-10},
	journal = {The Journal of Infectious Diseases},
	author = {Lanata, C F and Midthun, K and Black, R E and Butron, B and Huapaya, A and Penny, M E and Ventura, G and Gil, A and Jett-Goheen, M and Davidson, B L},
	month = aug,
	year = {1996},
	pmid = {8699054},
	keywords = {Animals, Antibodies, Viral, Developing Countries, Diarrhea, Infantile, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin A, Infant, Macaca mulatta, Male, Neutralization Tests, Peru, Placebos, Plaque Assay, Rotavirus Infections, Suburban Population, Viral Vaccines},
	pages = {268--275},
}

{"_id":"ovNd3PLAXpeBP5pQu","bibbaseid":"lanata-midthun-black-butron-huapaya-penny-ventura-gil-etal-safetyimmunogenicityandprotectiveefficacyofoneandthreedosesofthetetravalentrhesusrotavirusvaccineininfantsinlimaperu-1996","author_short":["Lanata, C F","Midthun, K","Black, R E","Butron, B","Huapaya, A","Penny, M E","Ventura, G","Gil, A","Jett-Goheen, M","Davidson, B L"],"bibdata":{"bibtype":"article","type":"article","title":"Safety, immunogenicity, and protective efficacy of one and three doses of the tetravalent rhesus rotavirus vaccine in infants in Lima, Peru","volume":"174","issn":"0022-1899","url":"http://www.ncbi.nlm.nih.gov/pubmed/8699054","abstract":"An oral rhesus-human rotavirus tetravalent (RRV-TV) vaccine (10(4) pfu of rhesus rotavirus [type G3] and of 3 human-rhesus reassortants [G1, G2, and G4]) was evaluated in a field trial in Lima, Peru. At 2, 3, and 4 months of age, infants received either a dose of RRV-TV, an initial dose of vaccine followed by a dose of placebo at 3 and 4 months, or a dose of placebo. Rotavirus-specific IgA responses were detected by ELISA in 75% of the three-dose vaccine group, 59% of the one-dose vaccine group (P = .05), and 24% of the placebo group (P \\textless .001): 64%, 48%, and 12% of each group, respectively, had a neutralizing antibody response to at least 1 serotype. Both one and three doses of vaccine failed to induce a significant level of protection against rotavirus diarrhea; however, they did provide some protection (range, 35%-66%) against more severe rotavirus diarrhea, especially for episodes caused by type G1.","number":"2","urldate":"2010-11-10","journal":"The Journal of Infectious Diseases","author":[{"propositions":[],"lastnames":["Lanata"],"firstnames":["C","F"],"suffixes":[]},{"propositions":[],"lastnames":["Midthun"],"firstnames":["K"],"suffixes":[]},{"propositions":[],"lastnames":["Black"],"firstnames":["R","E"],"suffixes":[]},{"propositions":[],"lastnames":["Butron"],"firstnames":["B"],"suffixes":[]},{"propositions":[],"lastnames":["Huapaya"],"firstnames":["A"],"suffixes":[]},{"propositions":[],"lastnames":["Penny"],"firstnames":["M","E"],"suffixes":[]},{"propositions":[],"lastnames":["Ventura"],"firstnames":["G"],"suffixes":[]},{"propositions":[],"lastnames":["Gil"],"firstnames":["A"],"suffixes":[]},{"propositions":[],"lastnames":["Jett-Goheen"],"firstnames":["M"],"suffixes":[]},{"propositions":[],"lastnames":["Davidson"],"firstnames":["B","L"],"suffixes":[]}],"month":"August","year":"1996","pmid":"8699054","keywords":"Animals, Antibodies, Viral, Developing Countries, Diarrhea, Infantile, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin A, Infant, Macaca mulatta, Male, Neutralization Tests, Peru, Placebos, Plaque Assay, Rotavirus Infections, Suburban Population, Viral Vaccines","pages":"268–275","bibtex":"@article{lanata_safety_1996,\n\ttitle = {Safety, immunogenicity, and protective efficacy of one and three doses of the tetravalent rhesus rotavirus vaccine in infants in {Lima}, {Peru}},\n\tvolume = {174},\n\tissn = {0022-1899},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/8699054},\n\tabstract = {An oral rhesus-human rotavirus tetravalent (RRV-TV) vaccine (10(4) pfu of rhesus rotavirus [type G3] and of 3 human-rhesus reassortants [G1, G2, and G4]) was evaluated in a field trial in Lima, Peru. At 2, 3, and 4 months of age, infants received either a dose of RRV-TV, an initial dose of vaccine followed by a dose of placebo at 3 and 4 months, or a dose of placebo. Rotavirus-specific IgA responses were detected by ELISA in 75\\% of the three-dose vaccine group, 59\\% of the one-dose vaccine group (P = .05), and 24\\% of the placebo group (P {\\textless} .001): 64\\%, 48\\%, and 12\\% of each group, respectively, had a neutralizing antibody response to at least 1 serotype. Both one and three doses of vaccine failed to induce a significant level of protection against rotavirus diarrhea; however, they did provide some protection (range, 35\\%-66\\%) against more severe rotavirus diarrhea, especially for episodes caused by type G1.},\n\tnumber = {2},\n\turldate = {2010-11-10},\n\tjournal = {The Journal of Infectious Diseases},\n\tauthor = {Lanata, C F and Midthun, K and Black, R E and Butron, B and Huapaya, A and Penny, M E and Ventura, G and Gil, A and Jett-Goheen, M and Davidson, B L},\n\tmonth = aug,\n\tyear = {1996},\n\tpmid = {8699054},\n\tkeywords = {Animals, Antibodies, Viral, Developing Countries, Diarrhea, Infantile, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin A, Infant, Macaca mulatta, Male, Neutralization Tests, Peru, Placebos, Plaque Assay, Rotavirus Infections, Suburban Population, Viral Vaccines},\n\tpages = {268--275},\n}\n\n","author_short":["Lanata, C F","Midthun, K","Black, R E","Butron, B","Huapaya, A","Penny, M E","Ventura, G","Gil, A","Jett-Goheen, M","Davidson, B L"],"key":"lanata_safety_1996","id":"lanata_safety_1996","bibbaseid":"lanata-midthun-black-butron-huapaya-penny-ventura-gil-etal-safetyimmunogenicityandprotectiveefficacyofoneandthreedosesofthetetravalentrhesusrotavirusvaccineininfantsinlimaperu-1996","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/8699054"},"keyword":["Animals","Antibodies","Viral","Developing Countries","Diarrhea","Infantile","Dose-Response Relationship","Drug","Enzyme-Linked Immunosorbent Assay","Female","Humans","Immunoglobulin A","Infant","Macaca mulatta","Male","Neutralization Tests","Peru","Placebos","Plaque Assay","Rotavirus Infections","Suburban Population","Viral Vaccines"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/robin.marlow","dataSources":["ix72eqAAMGCuupBaz"],"keywords":["animals","antibodies","viral","developing countries","diarrhea","infantile","dose-response relationship","drug","enzyme-linked immunosorbent assay","female","humans","immunoglobulin a","infant","macaca mulatta","male","neutralization tests","peru","placebos","plaque assay","rotavirus infections","suburban population","viral vaccines"],"search_terms":["safety","immunogenicity","protective","efficacy","one","three","doses","tetravalent","rhesus","rotavirus","vaccine","infants","lima","peru","lanata","midthun","black","butron","huapaya","penny","ventura","gil","jett-goheen","davidson"],"title":"Safety, immunogenicity, and protective efficacy of one and three doses of the tetravalent rhesus rotavirus vaccine in infants in Lima, Peru","year":1996}