@article{lappalainen_protection_2015,
	title = {Protection against live rotavirus challenge in mice induced by parenteral and mucosal delivery of {VP6} subunit rotavirus vaccine},
	volume = {160},
	issn = {1432-8798},
	doi = {10.1007/s00705-015-2461-8},
	abstract = {Live oral rotavirus (RV) vaccines are part of routine childhood immunization but are associated with adverse effects, particularly intussusception. We have developed a non-live combined RV - norovirus (NoV) vaccine candidate consisting of human RV inner-capsid rVP6 protein and NoV virus-like particles. To determine the effect of delivery route on induction of VP6-specific protective immunity, BALB/c mice were administered a vaccine containing RV rVP6 intramuscularly, intranasally or a combination of both, and challenged with murine RV. At least 65 \% protection against RV shedding was observed regardless of delivery route. The levels of post-challenge serum VP6-specific IgA titers correlated with protection.},
	language = {eng},
	number = {8},
	journal = {Archives of Virology},
	author = {Lappalainen, Suvi and Pastor, Ana Ruth and Malm, Maria and López-Guerrero, Vanessa and Esquivel-Guadarrama, Fernando and Palomares, Laura A. and Vesikari, Timo and Blazevic, Vesna},
	month = aug,
	year = {2015},
	pmid = {26016444},
	pmcid = {PMC4532722},
	pages = {2075--2078},
}

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