@article{RN171,
   author = {Latouche, E. L. and Sano, M. B. and Lorenzo, M. F. and Davalos, R. V. and Martin, R. C. G., 2nd},
   title = {Irreversible electroporation for the ablation of pancreatic malignancies: A patient-specific methodology},
   journal = {J Surg Oncol},
   volume = {115},
   number = {6},
   pages = {711-717},
   note = {1096-9098
Latouche, Eduardo L
Sano, Michael B
Lorenzo, Melvin F
Davalos, Rafael V
Martin, Robert C G 2nd
Journal Article
United States
2017/02/12
J Surg Oncol. 2017 May;115(6):711-717. doi: 10.1002/jso.24566. Epub 2017 Feb 10.},
   abstract = {BACKGROUND AND OBJECTIVES: Irreversible Electroporation (IRE) is a focal ablation technique highly attractive to surgical oncologists due to its non-thermal nature that allows for eradication of unresectable tumors in a minimally invasive procedure. In this study, our group sought to address the challenge of predicting the ablation volume with IRE for pancreatic procedures. METHODS: In compliance with HIPAA and hospital IRB approval, we established a pre-treatment planning methodology for IRE procedures in pancreas, which optimized treatment protocols for individual cases of locally advanced pancreatic cancer (LAPC). A new method for confirming treatment plans through intraoperative monitoring of tissue resistance was also proved feasible in three patients. RESULTS: Results from computational models showed good correlation with experimental data available in the literature. By implementing the proposed resistance measurement system 210 ± 26.1 (mean ± standard deviation) fewer pulses were delivered per electrode-pair. CONCLUSION: The proposed physics-based pre-treatment plan through finite element analysis and system for actively monitoring resistance changes can be paired to significantly reduce ablation times and risk of thermal effects during IRE procedures for LAPC.},
   keywords = {Ablation Techniques/*methods
Aged
Electroporation/*methods
Finite Element Analysis
Humans
Male
Models, Anatomic
Pancreatic Neoplasms/diagnostic imaging/*surgery
Precision Medicine/methods
Ire
impedance
pancreatic adenocarcinoma
real-time feedback
treatment planning},
   ISSN = {0022-4790},
   DOI = {10.1002/jso.24566},
   year = {2017},
   type = {Journal Article}
}

{"_id":"adgKuYf6apdqRGyRG","bibbaseid":"latouche-sano-lorenzo-davalos-martin-irreversibleelectroporationfortheablationofpancreaticmalignanciesapatientspecificmethodology-2017","author_short":["Latouche, E. L.","Sano, M. B.","Lorenzo, M. F.","Davalos, R. V.","Martin, R. C. G."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Latouche"],"firstnames":["E.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Sano"],"firstnames":["M.","B."],"suffixes":[]},{"propositions":[],"lastnames":["Lorenzo"],"firstnames":["M.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]},{"propositions":[],"lastnames":["Martin"],"firstnames":["R.","C.","G."],"suffixes":["2nd"]}],"title":"Irreversible electroporation for the ablation of pancreatic malignancies: A patient-specific methodology","journal":"J Surg Oncol","volume":"115","number":"6","pages":"711-717","note":"1096-9098 Latouche, Eduardo L Sano, Michael B Lorenzo, Melvin F Davalos, Rafael V Martin, Robert C G 2nd Journal Article United States 2017/02/12 J Surg Oncol. 2017 May;115(6):711-717. doi: 10.1002/jso.24566. Epub 2017 Feb 10.","abstract":"BACKGROUND AND OBJECTIVES: Irreversible Electroporation (IRE) is a focal ablation technique highly attractive to surgical oncologists due to its non-thermal nature that allows for eradication of unresectable tumors in a minimally invasive procedure. In this study, our group sought to address the challenge of predicting the ablation volume with IRE for pancreatic procedures. METHODS: In compliance with HIPAA and hospital IRB approval, we established a pre-treatment planning methodology for IRE procedures in pancreas, which optimized treatment protocols for individual cases of locally advanced pancreatic cancer (LAPC). A new method for confirming treatment plans through intraoperative monitoring of tissue resistance was also proved feasible in three patients. RESULTS: Results from computational models showed good correlation with experimental data available in the literature. By implementing the proposed resistance measurement system 210 ± 26.1 (mean ± standard deviation) fewer pulses were delivered per electrode-pair. CONCLUSION: The proposed physics-based pre-treatment plan through finite element analysis and system for actively monitoring resistance changes can be paired to significantly reduce ablation times and risk of thermal effects during IRE procedures for LAPC.","keywords":"Ablation Techniques/*methods Aged Electroporation/*methods Finite Element Analysis Humans Male Models, Anatomic Pancreatic Neoplasms/diagnostic imaging/*surgery Precision Medicine/methods Ire impedance pancreatic adenocarcinoma real-time feedback treatment planning","issn":"0022-4790","doi":"10.1002/jso.24566","year":"2017","bibtex":"@article{RN171,\n author = {Latouche, E. L. and Sano, M. B. and Lorenzo, M. F. and Davalos, R. V. and Martin, R. C. G., 2nd},\n title = {Irreversible electroporation for the ablation of pancreatic malignancies: A patient-specific methodology},\n journal = {J Surg Oncol},\n volume = {115},\n number = {6},\n pages = {711-717},\n note = {1096-9098\nLatouche, Eduardo L\nSano, Michael B\nLorenzo, Melvin F\nDavalos, Rafael V\nMartin, Robert C G 2nd\nJournal Article\nUnited States\n2017/02/12\nJ Surg Oncol. 2017 May;115(6):711-717. doi: 10.1002/jso.24566. Epub 2017 Feb 10.},\n abstract = {BACKGROUND AND OBJECTIVES: Irreversible Electroporation (IRE) is a focal ablation technique highly attractive to surgical oncologists due to its non-thermal nature that allows for eradication of unresectable tumors in a minimally invasive procedure. In this study, our group sought to address the challenge of predicting the ablation volume with IRE for pancreatic procedures. METHODS: In compliance with HIPAA and hospital IRB approval, we established a pre-treatment planning methodology for IRE procedures in pancreas, which optimized treatment protocols for individual cases of locally advanced pancreatic cancer (LAPC). A new method for confirming treatment plans through intraoperative monitoring of tissue resistance was also proved feasible in three patients. RESULTS: Results from computational models showed good correlation with experimental data available in the literature. By implementing the proposed resistance measurement system 210 ± 26.1 (mean ± standard deviation) fewer pulses were delivered per electrode-pair. CONCLUSION: The proposed physics-based pre-treatment plan through finite element analysis and system for actively monitoring resistance changes can be paired to significantly reduce ablation times and risk of thermal effects during IRE procedures for LAPC.},\n keywords = {Ablation Techniques/*methods\nAged\nElectroporation/*methods\nFinite Element Analysis\nHumans\nMale\nModels, Anatomic\nPancreatic Neoplasms/diagnostic imaging/*surgery\nPrecision Medicine/methods\nIre\nimpedance\npancreatic adenocarcinoma\nreal-time feedback\ntreatment planning},\n ISSN = {0022-4790},\n DOI = {10.1002/jso.24566},\n year = {2017},\n type = {Journal Article}\n}\n\n","author_short":["Latouche, E. L.","Sano, M. B.","Lorenzo, M. F.","Davalos, R. V.","Martin, R. C. 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