The high-resolution crystal structure of a parallel-stranded guanine tetraplex. Laughlan, G, Murchie, A I, Norman, D G, Moore, M H, Moody, P C, Lilley, D M, & Luisi, B Science (New York, N.Y.), 265(5171):520–4, July, 1994. ![The high-resolution crystal structure of a parallel-stranded guanine tetraplex. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
@article{Laughlan1994,
title = {The high-resolution crystal structure of a parallel-stranded guanine tetraplex.},
volume = {265},
issn = {0036-8075},
url = {http://www.ncbi.nlm.nih.gov/pubmed/8036494},
abstract = {Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.},
number = {5171},
journal = {Science (New York, N.Y.)},
author = {Laughlan, G and Murchie, A I and Norman, D G and Moore, M H and Moody, P C and Lilley, D M and Luisi, B},
month = jul,
year = {1994},
pmid = {8036494},
keywords = {\#nosource, Computer Graphics, Crystallization, Crystallography, Guanine, Guanine: chemistry, Hydrogen Bonding, Molecular Structure, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Oligodeoxyribonucleotides: chemistry, Sodium, X-Ray},
pages = {520--4},
}
Downloads: 0
{"_id":"rFEtQkzgFaoojctWy","bibbaseid":"laughlan-murchie-norman-moore-moody-lilley-luisi-thehighresolutioncrystalstructureofaparallelstrandedguaninetetraplex-1994","author_short":["Laughlan, G","Murchie, A I","Norman, D G","Moore, M H","Moody, P C","Lilley, D M","Luisi, B"],"bibdata":{"bibtype":"article","type":"article","title":"The high-resolution crystal structure of a parallel-stranded guanine tetraplex.","volume":"265","issn":"0036-8075","url":"http://www.ncbi.nlm.nih.gov/pubmed/8036494","abstract":"Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.","number":"5171","journal":"Science (New York, N.Y.)","author":[{"propositions":[],"lastnames":["Laughlan"],"firstnames":["G"],"suffixes":[]},{"propositions":[],"lastnames":["Murchie"],"firstnames":["A","I"],"suffixes":[]},{"propositions":[],"lastnames":["Norman"],"firstnames":["D","G"],"suffixes":[]},{"propositions":[],"lastnames":["Moore"],"firstnames":["M","H"],"suffixes":[]},{"propositions":[],"lastnames":["Moody"],"firstnames":["P","C"],"suffixes":[]},{"propositions":[],"lastnames":["Lilley"],"firstnames":["D","M"],"suffixes":[]},{"propositions":[],"lastnames":["Luisi"],"firstnames":["B"],"suffixes":[]}],"month":"July","year":"1994","pmid":"8036494","keywords":"#nosource, Computer Graphics, Crystallization, Crystallography, Guanine, Guanine: chemistry, Hydrogen Bonding, Molecular Structure, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Oligodeoxyribonucleotides: chemistry, Sodium, X-Ray","pages":"520–4","bibtex":"@article{Laughlan1994,\n\ttitle = {The high-resolution crystal structure of a parallel-stranded guanine tetraplex.},\n\tvolume = {265},\n\tissn = {0036-8075},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/8036494},\n\tabstract = {Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.},\n\tnumber = {5171},\n\tjournal = {Science (New York, N.Y.)},\n\tauthor = {Laughlan, G and Murchie, A I and Norman, D G and Moore, M H and Moody, P C and Lilley, D M and Luisi, B},\n\tmonth = jul,\n\tyear = {1994},\n\tpmid = {8036494},\n\tkeywords = {\\#nosource, Computer Graphics, Crystallization, Crystallography, Guanine, Guanine: chemistry, Hydrogen Bonding, Molecular Structure, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Oligodeoxyribonucleotides: chemistry, Sodium, X-Ray},\n\tpages = {520--4},\n}\n\n","author_short":["Laughlan, G","Murchie, A I","Norman, D G","Moore, M H","Moody, P C","Lilley, D M","Luisi, B"],"key":"Laughlan1994","id":"Laughlan1994","bibbaseid":"laughlan-murchie-norman-moore-moody-lilley-luisi-thehighresolutioncrystalstructureofaparallelstrandedguaninetetraplex-1994","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/8036494"},"keyword":["#nosource","Computer Graphics","Crystallization","Crystallography","Guanine","Guanine: chemistry","Hydrogen Bonding","Molecular Structure","Nucleic Acid Conformation","Oligodeoxyribonucleotides","Oligodeoxyribonucleotides: chemistry","Sodium","X-Ray"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/eric.larG4","dataSources":["4i5C7S78DvJNsaHyg","5L2zM5wNE5CBYNuea"],"keywords":["#nosource","computer graphics","crystallization","crystallography","guanine","guanine: chemistry","hydrogen bonding","molecular structure","nucleic acid conformation","oligodeoxyribonucleotides","oligodeoxyribonucleotides: chemistry","sodium","x-ray"],"search_terms":["high","resolution","crystal","structure","parallel","stranded","guanine","tetraplex","laughlan","murchie","norman","moore","moody","lilley","luisi"],"title":"The high-resolution crystal structure of a parallel-stranded guanine tetraplex.","year":1994}