Delayed cauda equina compression after spinal dura repair with BioGlue: magnetic resonance imaging and computed tomography aspects of two cases of "glue-oma". Lauvin, M., Zemmoura, I., Cazals, X., & Cottier, J. The spine journal : official journal of the North American Spine Society, 15(1):e5--8, ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA, January, 2015.
abstract   bibtex   
BACKGROUND CONTEXT: Bovine serum albumin and glutaraldehyde (BSAG) (BioGlue) is a surgical adhesive widely used for off-label applications in neurosurgical procedures to minimize the risk of cerebrospinal fluid leakage after dural closure. PURPOSE: To describe magnetic resonance imaging (MRI) and computed tomography (CT) aspects of two cases of postoperative BSAG expansion causing delayed cauda equina compression requiring further surgery. STUDY DESIGN: A case report. PATIENT SAMPLE: Two cases of delayed cauda equina compression complicating the closure, with BSAG, of small unintentional tears in the dura requiring lumbar decompressive surgery. OUTCOME MEASURES: They included postoperative CT and MRI findings. METHODS: We compared postoperative imaging and perioperative findings during subsequent surgery. RESULTS: In both cases, imaging showed cauda equina compression due to epidural masses found during subsequent surgery comprising BioGlue. These masses appeared slightly hyperdense on CT scans and markedly hypointense on T2-weighted MRI scans. CONCLUSIONS: When applied as a thick layer during use as a dural sealant, BSAG may swell, leading to a symptomatic "glue-oma" giving a hypointense image on T2-weighted MRI scans.
@article{Lauvin2015,
abstract = {BACKGROUND CONTEXT: Bovine serum albumin and glutaraldehyde (BSAG) (BioGlue) is a surgical adhesive widely used for off-label applications in neurosurgical procedures to minimize the risk of cerebrospinal fluid leakage after dural closure.

PURPOSE: To describe magnetic resonance imaging (MRI) and computed tomography (CT) aspects of two cases of postoperative BSAG expansion causing delayed cauda equina compression requiring further surgery.

STUDY DESIGN: A case report.

PATIENT SAMPLE: Two cases of delayed cauda equina compression complicating the closure, with BSAG, of small unintentional tears in the dura requiring lumbar decompressive surgery.

OUTCOME MEASURES: They included postoperative CT and MRI findings.

METHODS: We compared postoperative imaging and perioperative findings during subsequent surgery.

RESULTS: In both cases, imaging showed cauda equina compression due to epidural masses found during subsequent surgery comprising BioGlue. These masses appeared slightly hyperdense on CT scans and markedly hypointense on T2-weighted MRI scans.

CONCLUSIONS: When applied as a thick layer during use as a dural sealant, BSAG may swell, leading to a symptomatic "glue-oma" giving a hypointense image on T2-weighted MRI scans.},
author = {Lauvin, Marie-Agn\`{e}s and Zemmoura, Ilyess and Cazals, Xavier and Cottier, Jean-Philippe},
issn = {1878-1632},
journal = {The spine journal : official journal of the North American Spine Society},
keywords = {BioGlue (BSAG: bovine serum albumin and glutaralde,Cauda equina compression,Dural closure techniques,Dural sealants,MRI,SEALANTS,SURGERY,Spinal surgery},
month = jan,
number = {1},
pages = {e5--8},
publisher = {ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA},
title = {{Delayed cauda equina compression after spinal dura repair with BioGlue: magnetic resonance imaging and computed tomography aspects of two cases of "glue-oma".}},
volume = {15},
year = {2015}
}

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