Development and characterization of candidate rotavirus vaccine strains derived from children with diarrhoea in Vietnam

Development and characterization of candidate rotavirus vaccine strains derived from children with diarrhoea in Vietnam. Le, L. T., Nguyen, T. V., Nguyen, P. M., Huong, N. T., Huong, N. T., Huong, N. T. M., Hanh, T. B., Ha, D. N., Anh, D. D., Gentsch, J. R., Wang, Y., Esona, M. D., Glass, R. I., Steele, A. D., Kilgore, P. E., Man, N. V., Jiang, B., & Hien, N. D. Vaccine, 27, Supplement 5:F130–F138, November, 2009.

Paper doi abstract bibtex

In Vietnam, rotavirus infection accounts for more than one-half of all hospitalizations for diarrhoea among children less than 5 years of age. While new vaccines to prevent rotavirus diarrhoea have been developed and introduced into some countries by multinational manufacturers, the ability for developing countries such as Vietnam to introduce several new and important vaccines into the routine infant immunization schedule may be challenging. In order to be partially self-sufficient in vaccine production, Vietnam has pursued the development of several rotavirus strains as candidate vaccines using isolates obtained from Vietnamese children with diarrhoea. This paper describes the origin, isolation and characterization of 3 human rotavirus strains being considered for further vaccine development in Vietnam. The goal is to prepare a monovalent G1P [8] rotavirus vaccine using one of these strains obtained in Vietnam and naturally attenuated by multiple passages in cell culture. While this is an ambitious project that will require several years’ work, we are using the lessons learned to improve the overall quality of vaccine production including the use of Vero cell techniques for the manufacture of other vaccines in Vietnam.

@article{le_development_2009,
	series = {Rotavirus in {Asia}: {Updates} on {Disease} {Burden}, {Genotypes} and {Vaccine} {Introduction}},
	title = {Development and characterization of candidate rotavirus vaccine strains derived from children with diarrhoea in {Vietnam}},
	volume = {27, Supplement 5},
	issn = {0264-410X},
	url = {http://www.sciencedirect.com/science/article/pii/S0264410X0901295X},
	doi = {10.1016/j.vaccine.2009.08.086},
	abstract = {In Vietnam, rotavirus infection accounts for more than one-half of all hospitalizations for diarrhoea among children less than 5 years of age. While new vaccines to prevent rotavirus diarrhoea have been developed and introduced into some countries by multinational manufacturers, the ability for developing countries such as Vietnam to introduce several new and important vaccines into the routine infant immunization schedule may be challenging. In order to be partially self-sufficient in vaccine production, Vietnam has pursued the development of several rotavirus strains as candidate vaccines using isolates obtained from Vietnamese children with diarrhoea. This paper describes the origin, isolation and characterization of 3 human rotavirus strains being considered for further vaccine development in Vietnam. The goal is to prepare a monovalent G1P [8] rotavirus vaccine using one of these strains obtained in Vietnam and naturally attenuated by multiple passages in cell culture. While this is an ambitious project that will require several years’ work, we are using the lessons learned to improve the overall quality of vaccine production including the use of Vero cell techniques for the manufacture of other vaccines in Vietnam.},
	urldate = {2015-10-20},
	journal = {Vaccine},
	author = {Le, Luan T. and Nguyen, Trang V. and Nguyen, Phuong M. and Huong, Nguyen T. and Huong, Ngo T. and Huong, Nguyen T. M. and Hanh, Tran B. and Ha, Dang N. and Anh, Dang D. and Gentsch, Jon R. and Wang, Yuhuan and Esona, Mathew D. and Glass, Roger I. and Steele, A. Duncan and Kilgore, Paul E. and Man, Nguyen V. and Jiang, Baoming and Hien, Nguyen D.},
	month = nov,
	year = {2009},
	pages = {F130--F138},
}

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