@article{ WOS:000474316600022,
Author = {Le Bihan, Yann-Vai and Lanigan, Rachel M. and Atrash, Butrus and
   McLaughlin, Mark G. and Velupillai, Srikannathasan and Malcolm, Andrew
   G. and England, Katherine S. and Ruda, Gian Filippo and Mok, N. Yi and
   Tumber, Anthony and Tomlin, Kathy and Saville, Harry and Shehu, Erald
   and McAndrew, Craig and Carmichael, LeAnne and Bennett, James M. and
   Jeganathan, Fiona and Eve, Paul and Donovan, Adam and Hayes, Angela and
   Wood, Francesca and Raynaud, Florence I. and Fedorov, Oleg and Brennan,
   Paul E. and Burke, Rosemary and van Montfort, Rob L. M. and Rossanese,
   Olivia W. and Blagg, Julian and Bavetsias, Vassilios},
Title = {C8-substituted pyrido{[}3,4-d]pyrimidin-4(3H)-ones:
   Studies towards the identification of potent, cell penetrant Jumonji C
   domain containing histone lysine demethylase 4 subfamily (KDM4)
   inhibitors, compound profiling in cell-based target engagement assays},
Journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY},
Year = {2019},
Volume = {177},
Pages = {316-337},
Month = {SEP 1},
DOI = {10.1016/j.ejmech.2019.05.041},
ISSN = {0223-5234},
EISSN = {1768-3254},
ResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019
   McLaughlin, Mark/N-8192-2019
   Lanigan, Rachel/B-4830-2015
   },
ORCID-Numbers = {Le Bihan, Yann-Vai/0000-0002-6850-9706
   Rossanese, Olivia/0000-0002-1262-9522
   England, Katherine/0000-0002-4921-7505
   Fedorov, Oleg/0000-0001-5268-6399
   Tumber, Anthony/0000-0003-1958-8353
   Raynaud, Florence/0000-0003-0957-6279
   McLaughlin, Mark/0000-0002-5999-4703},
Unique-ID = {WOS:000474316600022},
}

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W.","Blagg, J.","Bavetsias, V."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Le","Bihan"],"firstnames":["Yann-Vai"],"suffixes":[]},{"propositions":[],"lastnames":["Lanigan"],"firstnames":["Rachel","M."],"suffixes":[]},{"propositions":[],"lastnames":["Atrash"],"firstnames":["Butrus"],"suffixes":[]},{"propositions":[],"lastnames":["McLaughlin"],"firstnames":["Mark","G."],"suffixes":[]},{"propositions":[],"lastnames":["Velupillai"],"firstnames":["Srikannathasan"],"suffixes":[]},{"propositions":[],"lastnames":["Malcolm"],"firstnames":["Andrew","G."],"suffixes":[]},{"propositions":[],"lastnames":["England"],"firstnames":["Katherine","S."],"suffixes":[]},{"propositions":[],"lastnames":["Ruda"],"firstnames":["Gian","Filippo"],"suffixes":[]},{"propositions":[],"lastnames":["Mok"],"firstnames":["N.","Yi"],"suffixes":[]},{"propositions":[],"lastnames":["Tumber"],"firstnames":["Anthony"],"suffixes":[]},{"propositions":[],"lastnames":["Tomlin"],"firstnames":["Kathy"],"suffixes":[]},{"propositions":[],"lastnames":["Saville"],"firstnames":["Harry"],"suffixes":[]},{"propositions":[],"lastnames":["Shehu"],"firstnames":["Erald"],"suffixes":[]},{"propositions":[],"lastnames":["McAndrew"],"firstnames":["Craig"],"suffixes":[]},{"propositions":[],"lastnames":["Carmichael"],"firstnames":["LeAnne"],"suffixes":[]},{"propositions":[],"lastnames":["Bennett"],"firstnames":["James","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jeganathan"],"firstnames":["Fiona"],"suffixes":[]},{"propositions":[],"lastnames":["Eve"],"firstnames":["Paul"],"suffixes":[]},{"propositions":[],"lastnames":["Donovan"],"firstnames":["Adam"],"suffixes":[]},{"propositions":[],"lastnames":["Hayes"],"firstnames":["Angela"],"suffixes":[]},{"propositions":[],"lastnames":["Wood"],"firstnames":["Francesca"],"suffixes":[]},{"propositions":[],"lastnames":["Raynaud"],"firstnames":["Florence","I."],"suffixes":[]},{"propositions":[],"lastnames":["Fedorov"],"firstnames":["Oleg"],"suffixes":[]},{"propositions":[],"lastnames":["Brennan"],"firstnames":["Paul","E."],"suffixes":[]},{"propositions":[],"lastnames":["Burke"],"firstnames":["Rosemary"],"suffixes":[]},{"propositions":["van"],"lastnames":["Montfort"],"firstnames":["Rob","L.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Rossanese"],"firstnames":["Olivia","W."],"suffixes":[]},{"propositions":[],"lastnames":["Blagg"],"firstnames":["Julian"],"suffixes":[]},{"propositions":[],"lastnames":["Bavetsias"],"firstnames":["Vassilios"],"suffixes":[]}],"title":"C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays","journal":"EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY","year":"2019","volume":"177","pages":"316-337","month":"SEP 1","doi":"10.1016/j.ejmech.2019.05.041","issn":"0223-5234","eissn":"1768-3254","researcherid-numbers":"Fedorov, Oleg/A-3201-2019 McLaughlin, Mark/N-8192-2019 Lanigan, Rachel/B-4830-2015 ","orcid-numbers":"Le Bihan, Yann-Vai/0000-0002-6850-9706 Rossanese, Olivia/0000-0002-1262-9522 England, Katherine/0000-0002-4921-7505 Fedorov, Oleg/0000-0001-5268-6399 Tumber, Anthony/0000-0003-1958-8353 Raynaud, Florence/0000-0003-0957-6279 McLaughlin, Mark/0000-0002-5999-4703","unique-id":"WOS:000474316600022","bibtex":"@article{ WOS:000474316600022,\nAuthor = {Le Bihan, Yann-Vai and Lanigan, Rachel M. and Atrash, Butrus and\n McLaughlin, Mark G. and Velupillai, Srikannathasan and Malcolm, Andrew\n G. and England, Katherine S. and Ruda, Gian Filippo and Mok, N. Yi and\n Tumber, Anthony and Tomlin, Kathy and Saville, Harry and Shehu, Erald\n and McAndrew, Craig and Carmichael, LeAnne and Bennett, James M. and\n Jeganathan, Fiona and Eve, Paul and Donovan, Adam and Hayes, Angela and\n Wood, Francesca and Raynaud, Florence I. and Fedorov, Oleg and Brennan,\n Paul E. and Burke, Rosemary and van Montfort, Rob L. M. and Rossanese,\n Olivia W. and Blagg, Julian and Bavetsias, Vassilios},\nTitle = {C8-substituted pyrido{[}3,4-d]pyrimidin-4(3H)-ones:\n Studies towards the identification of potent, cell penetrant Jumonji C\n domain containing histone lysine demethylase 4 subfamily (KDM4)\n inhibitors, compound profiling in cell-based target engagement assays},\nJournal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2019},\nVolume = {177},\nPages = {316-337},\nMonth = {SEP 1},\nDOI = {10.1016/j.ejmech.2019.05.041},\nISSN = {0223-5234},\nEISSN = {1768-3254},\nResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019\n McLaughlin, Mark/N-8192-2019\n Lanigan, Rachel/B-4830-2015\n },\nORCID-Numbers = {Le Bihan, Yann-Vai/0000-0002-6850-9706\n Rossanese, Olivia/0000-0002-1262-9522\n England, Katherine/0000-0002-4921-7505\n Fedorov, Oleg/0000-0001-5268-6399\n Tumber, Anthony/0000-0003-1958-8353\n Raynaud, Florence/0000-0003-0957-6279\n McLaughlin, Mark/0000-0002-5999-4703},\nUnique-ID = {WOS:000474316600022},\n}\n\n","author_short":["Le Bihan, Y.","Lanigan, R. M.","Atrash, B.","McLaughlin, M. G.","Velupillai, S.","Malcolm, A. G.","England, K. S.","Ruda, G. F.","Mok, N. Y.","Tumber, A.","Tomlin, K.","Saville, H.","Shehu, E.","McAndrew, C.","Carmichael, L.","Bennett, J. M.","Jeganathan, F.","Eve, P.","Donovan, A.","Hayes, A.","Wood, F.","Raynaud, F. I.","Fedorov, O.","Brennan, P. E.","Burke, R.","van Montfort, R. L. M.","Rossanese, O. W.","Blagg, J.","Bavetsias, V."],"key":"WOS:000474316600022","id":"WOS:000474316600022","bibbaseid":"lebihan-lanigan-atrash-mclaughlin-velupillai-malcolm-england-ruda-etal-c8substitutedpyrido34dpyrimidin43honesstudiestowardstheidentificationofpotentcellpenetrantjumonjicdomaincontaininghistonelysinedemethylase4subfamilykdm4inhibitorscompoundprofilingincellbasedtargetengagementassays-2019","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/HECPruWhe6gDg5ZWN","dataSources":["qhzgQBKWKwmm6xY73","NBNKNR2KcNSWDgFcf","4mccB2G6uYe3AhfDs"],"keywords":[],"search_terms":["substituted","pyrido","pyrimidin","ones","studies","towards","identification","potent","cell","penetrant","jumonji","domain","containing","histone","lysine","demethylase","subfamily","kdm4","inhibitors","compound","profiling","cell","based","target","engagement","assays","le bihan","lanigan","atrash","mclaughlin","velupillai","malcolm","england","ruda","mok","tumber","tomlin","saville","shehu","mcandrew","carmichael","bennett","jeganathan","eve","donovan","hayes","wood","raynaud","fedorov","brennan","burke","van montfort","rossanese","blagg","bavetsias"],"title":"C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays","year":2019}