Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019. Lechien, J., R., Chiesa-Estomba, C., M., Place, S., Van Laethem, Y., Cabaraux, P., Mat, Q., Huet, K., Plzak, J., Horoi, M., Hans, S., Rosaria Barillari, M., Cammaroto, G., Fakhry, N., Martiny, D., Ayad, T., Jouffe, L., Hopkins, C., Saussez, S., Blecic, S., De Siati, D., R., Leich, P., Souchay, C., Rossi, C., Journe, F., Hsieh, J., Ris, L., El Afia, F., Harmegnies, B., Distinguin, L., Chekkoury-Idrissi, Y., Circiu, M., Lavigne, P., Lopez Delgado, I., Calvo-Henriquez, C., Falanga, C., Coppee, F., Bon, S., D., Rodriguez, A., Dequanter, D., Cornelis, J., P., Vergez, S., Koenen, L., Giuditta, M., Molteni, G., Tucciarone, M., Radulesco, T., Khalife, M., Fourneau, A., F., Cherifi, S., Manto, M., Michel, J., Radulesco, T., Molteni, G., Tucciarone, M., Mannelli, G., & Cantarella, G. Journal of Internal Medicine, 2020. doi abstract bibtex 4 downloads Background: The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown. Objective: To study the clinical presentation of COVID-19 in Europe. Methods: Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes. Results: A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients. Conclusion: The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.
@article{
title = {Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019},
type = {article},
year = {2020},
keywords = {COVID-19,Europe,clinical,coronavirus,epidemiological,medicine,patients,symptoms},
id = {d75ffd29-4cb8-3373-a54d-90e83a14275b},
created = {2020-10-23T21:05:17.034Z},
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profile_id = {95e10851-cdf3-31de-9f82-1ab629e601b0},
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last_modified = {2020-10-23T21:05:17.034Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
private_publication = {false},
abstract = {Background: The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown. Objective: To study the clinical presentation of COVID-19 in Europe. Methods: Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes. Results: A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients. Conclusion: The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.},
bibtype = {article},
author = {Lechien, Jerome R. and Chiesa-Estomba, Carlos M. and Place, Sammy and Van Laethem, Yves and Cabaraux, Pierre and Mat, Quentin and Huet, Kathy and Plzak, Jan and Horoi, Mihaela and Hans, Stéphane and Rosaria Barillari, Maria and Cammaroto, Giovanni and Fakhry, Nicolas and Martiny, Delphine and Ayad, Tareck and Jouffe, Lionel and Hopkins, Claire and Saussez, Sven and Blecic, Serge and De Siati, Daniele R. and Leich, Pierre and Souchay, Christel and Rossi, Camelia and Journe, Fabrice and Hsieh, Julien and Ris, Laurence and El Afia, Fahd and Harmegnies, Bernard and Distinguin, Lea and Chekkoury-Idrissi, Younes and Circiu, Marta and Lavigne, Philippe and Lopez Delgado, Irene and Calvo-Henriquez, Christian and Falanga, Chiara and Coppee, Frederique and Bon, Serge D. and Rodriguez, Alexandra and Dequanter, Didier and Cornelis, Jean Philippe and Vergez, Sebastien and Koenen, Lukas and Giuditta, Mannelli and Molteni, Gabriele and Tucciarone, Manuel and Radulesco, Thomas and Khalife, Mohamad and Fourneau, Anne Francoise and Cherifi, Soraya and Manto, Mario and Michel, Justin and Radulesco, Thomas and Molteni, Gabriele and Tucciarone, Manuel and Mannelli, Giuditta and Cantarella, Giovanna},
doi = {10.1111/joim.13089},
journal = {Journal of Internal Medicine}
}
Downloads: 4
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Objective: To study the clinical presentation of COVID-19 in Europe. Methods: Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes. Results: A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients. Conclusion: The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.","bibtype":"article","author":"Lechien, Jerome R. and Chiesa-Estomba, Carlos M. and Place, Sammy and Van Laethem, Yves and Cabaraux, Pierre and Mat, Quentin and Huet, Kathy and Plzak, Jan and Horoi, Mihaela and Hans, Stéphane and Rosaria Barillari, Maria and Cammaroto, Giovanni and Fakhry, Nicolas and Martiny, Delphine and Ayad, Tareck and Jouffe, Lionel and Hopkins, Claire and Saussez, Sven and Blecic, Serge and De Siati, Daniele R. and Leich, Pierre and Souchay, Christel and Rossi, Camelia and Journe, Fabrice and Hsieh, Julien and Ris, Laurence and El Afia, Fahd and Harmegnies, Bernard and Distinguin, Lea and Chekkoury-Idrissi, Younes and Circiu, Marta and Lavigne, Philippe and Lopez Delgado, Irene and Calvo-Henriquez, Christian and Falanga, Chiara and Coppee, Frederique and Bon, Serge D. and Rodriguez, Alexandra and Dequanter, Didier and Cornelis, Jean Philippe and Vergez, Sebastien and Koenen, Lukas and Giuditta, Mannelli and Molteni, Gabriele and Tucciarone, Manuel and Radulesco, Thomas and Khalife, Mohamad and Fourneau, Anne Francoise and Cherifi, Soraya and Manto, Mario and Michel, Justin and Radulesco, Thomas and Molteni, Gabriele and Tucciarone, Manuel and Mannelli, Giuditta and Cantarella, Giovanna","doi":"10.1111/joim.13089","journal":"Journal of Internal Medicine","bibtex":"@article{\n title = {Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019},\n type = {article},\n year = {2020},\n keywords = {COVID-19,Europe,clinical,coronavirus,epidemiological,medicine,patients,symptoms},\n id = {d75ffd29-4cb8-3373-a54d-90e83a14275b},\n created = {2020-10-23T21:05:17.034Z},\n file_attached = {false},\n profile_id = {95e10851-cdf3-31de-9f82-1ab629e601b0},\n group_id = {f4f27d7f-2273-33eb-bbb9-78e3e17cc268},\n last_modified = {2020-10-23T21:05:17.034Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n private_publication = {false},\n abstract = {Background: The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown. Objective: To study the clinical presentation of COVID-19 in Europe. Methods: Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes. Results: A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients. Conclusion: The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. 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