Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population. Leigh Brown, A. J., Frost, S. D. W., Mathews, W. C., Dawson, K., Hellmann, N. S., Daar, E. S., Richman, D. D., & Little, S. J. The Journal of Infectious Diseases, 187(4):683–686, February, 2003.
doi  abstract   bibtex   
Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only approximately 20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.
@article{leigh_brown_transmission_2003,
	title = {Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population},
	volume = {187},
	issn = {0022-1899},
	doi = {10.1086/367989},
	abstract = {Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only approximately 20\% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.},
	language = {eng},
	number = {4},
	journal = {The Journal of Infectious Diseases},
	author = {Leigh Brown, Andrew J. and Frost, Simon D. W. and Mathews, W. Christopher and Dawson, Keith and Hellmann, Nicholas S. and Daar, Eric S. and Richman, Douglas D. and Little, Susan J.},
	month = feb,
	year = {2003},
	pmid = {12599087},
	keywords = {Anti-HIV Agents, Drug Resistance, Viral, Female, HIV Infections, HIV-1, Humans, Male, North America, Retrospective Studies, Treatment Failure, Urban Population, Viral Load},
	pages = {683--686},
}

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