@article{Lemmer2024,
abstract = {In the quest for heightened protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, we engineered a prototype vaccine utilizing the plant expression system of Nicotiana benthamiana, to produce a recombinant SARS-CoV-2 virus-like particle (VLP) vaccine presenting the S-protein from the Beta (B.1.351) variant of concern (VOC). This innovative vaccine, formulated with either a squalene oil-in-water emulsion or a synthetic CpG oligodeoxynucleotide adjuvant, demonstrated efficacy in a golden Syrian Hamster challenge model. The Beta VLP vaccine induced a robust humoral immune response, with serum exhibiting neutralization not only against SARS-CoV-2 Beta but also cross-neutralizing Delta and Omicron pseudoviruses. Protective efficacy was demonstrated, evidenced by reduced viral RNA copies and mitigated weight loss and lung damage compared to controls. This compelling data instills confidence in the creation of a versatile platform for the local manufacturing of potential pan-sarbecovirus vaccines, against evolving viral threats.},
author = {Lemmer, Yolandy and Chapman, Ros and Abolnik, Celia and Smith, Tanja and Sch{\"{a}}fer, Georgia and Hermanus, Tandile and du Preez, Ilse and Goosen, Kruger and Sepotokele, Kamogelo M and Gers, Sophette and Suliman, Tasnim and Preiser, Wolfgang and Shaw, Megan L and Roth, Robyn and Truyts, Alma and Chipangura, John and Magwaza, Martin and Mahanjana, Osborn and Moore, Penny L and O'Kennedy, Martha M},
doi = {10.1016/J.VACCINE.2024.01.036},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Lemmer et al. - 2024 - Protective efficacy of a plant-produced beta variant rSARS-CoV-2 VLP vaccine in golden Syrian hamsters.pdf:pdf},
issn = {0264-410X},
journal = {Vaccine},
keywords = {Efficacy,Immunogenicity,OA,Pan-sarbecovirus,Virus-like particles,fund{\_}not{\_}ack,original},
mendeley-tags = {OA,fund{\_}not{\_}ack,original},
month = {jan},
pmid = {38238112},
publisher = {Elsevier},
title = {{Protective efficacy of a plant-produced beta variant rSARS-CoV-2 VLP vaccine in golden Syrian hamsters}},
year = {2024}
}

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This innovative vaccine, formulated with either a squalene oil-in-water emulsion or a synthetic CpG oligodeoxynucleotide adjuvant, demonstrated efficacy in a golden Syrian Hamster challenge model. The Beta VLP vaccine induced a robust humoral immune response, with serum exhibiting neutralization not only against SARS-CoV-2 Beta but also cross-neutralizing Delta and Omicron pseudoviruses. Protective efficacy was demonstrated, evidenced by reduced viral RNA copies and mitigated weight loss and lung damage compared to controls. 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